Abstract: A method for generating feedback in a multimedia entertainment system, the method comprising: obtaining an output stream to be output by the multimedia entertainment system; performing feature analysis to identify a feature in the output stream; determining a feedback based on the identified feature; controlling a main audiovisual display to output the output stream; and controlling a peripheral device to output the determined feedback.

Abstract: Disclosed herein are engineered RNAs and compositions comprising the same for treatment of diseases or conditions in a subject. Also disclosed herein are methods of treating diseases or conditions in a subject by administering engineered RNAs, polynucleotides encoding the described engineered RNAs, or pharmaceutical compositions described here.

Abstract: Provided herein are engineered guides configured, upon hybridization to target RNA molecules, to form double stranded RNA substrates comprising (i) a region comprising at least one structural feature; and (ii) a first internal loop and a second internal loop, wherein the double stranded RNA substrates recruit RNA editing entities and facilitate chemical modifications of base nucleotides in the target RNA molecules. Also provided herein are compositions, vectors, and cells comprising the engineered guides disclosed herein. Also provided herein are methods of introducing the engineered guides described herein into cells and methods of treating a disease or condition in a subject in need thereof comprising administering to the subject the engineered guides, polynucleotides encoding the engineered guides, delivery vehicles comprising such engineered guides or such polynucleotides, or pharmaceutical compositions comprising any one of these as described herein.

Abstract: Disclosed herein are engineered guide RNAs and compositions comprising the same for treatment of diseases or conditions in a subject. Also disclosed herein are methods of treating diseases or conditions in a subject by administering engineered guide RNAs or pharmaceutical compositions described herein.

Abstract: Disclosed herein are engineered guide RNAs and compositions comprising the same for treatment of diseases or conditions in a subject. Also disclosed herein are methods of treating diseases or conditions in a subject by administering engineered guide RNAs or pharmaceutical compositions described herein.

Abstract: A method of manufacturing a water-soluble transfer stack comprising multilayer two-dimensional material includes: i. Providing a growth stack comprising a growth substrate and a two-dimensional material layer; ii. Applying an intercalating solution, to the growth stack; iii. Applying a transfer layer comprising a water-soluble polymer film, to the growth stack; iv. Delaminating the water-soluble polymer film together with the two-dimensional material layer, thereby obtaining a delaminated film, from the growth substrate; and v. Repeating steps i.-iv. a number of times, wherein the delaminated film is used as the transfer layer; thereby manufacturing a water-soluble transfer stack comprising multilayer two-dimensional material.

Abstract: A method for generating feedback in a multimedia entertainment system, the method comprising: obtaining an output stream to be output by the multimedia entertainment system; performing feature analysis to identify a feature in the output stream; determining a feedback based on the identified feature; controlling a main audiovisual display to output the output stream; and controlling a peripheral device to output the determined feedback.

Abstract: An interaction method for notifying a first user of one or more software features available on a device of the first user includes, for respective ones of a plurality of software features, recording interactions with the software feature by the first user; and calculating a level of interaction with the software feature, and then selecting for notification one or more of the plurality of software features, responsive to selection criteria comprising the respective level of interaction with each software feature, and generating for display to the first user a notification of the selected one or more of the plurality of software features.

Abstract: An interaction method for notifying a first user of one or more software features available on a device of the first user includes, for respective ones of a plurality of software features, recording interactions with the software feature by the first user; and calculating a level of interaction with the software feature, and then selecting for notification one or more of the plurality of software features, responsive to selection criteria comprising the respective level of interaction with each software feature, and generating for display to the first user a notification of the selected one or more of the plurality of software features.

Abstract: This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidising or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidised or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.

Abstract: This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidizing or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidized or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.

Abstract: A method for controlling permissions relating to online interactions of a sub-account, the sub-account being linked with a main account, the method comprising modifying permissions associated with a sub-account using the linked main account, the permissions controlling the ability of a sub-account to engage in online interactions, wherein the sub-account is a user account that is restricted such that a user of the sub-account is not able to modify permissions of the sub-account to the same degree as a user of the linked main account.

Abstract: The devices, methods, and algorithms of the present disclosure provide a hot food holding cabinet to detect the presence and uniquely identify a plurality of food holding trays within a plurality of food holding locations within a hot food holding cabinet. There can also be multiple, separate food holding cabinets that are linked together. Timing and other functions related to the storage of the food holding trays are initiated automatically, without any manual input from a user. This allows for the automated initiation and tracking of product quality parameters by the cabinet computer. The parameters can include product timers and holding profiles, and whether the food holding trays are removed, transferred between bins in a single cabinet, or transferred between separate cabinets.

Abstract: The present disclosure relates to a holder for a test object, more specifically to a holder for measuring electrochemical properties of the test object.

Abstract: A component, for example an aerofoil vane or other gas path structure in a gas turbine machine such as a gas turbine engine, in which an insulated electrical conductor path is embedded structurally integrally, and in which electromagnetic shielding, for the embedded electrical conductor path is provided structurally integrally.

Abstract: This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidising or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidised or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.

Abstract: The present application discloses a method for separating a graphene-support layer laminate from a conducting substrate-graphene-support layer laminate, using a gentle, controllable electrochemical method. In this way, substrates which are fragile, expensive or difficult to manufacture can be used—and even re-used—without damage or destruction of the substrate or the graphene.

Abstract: This invention relates to the identification of modified cytosine residues, such as 5-methylcytosine (5mC), 5-hydroxymethylcytosine (5hmC) and 5-formylcytosine (5fC) to be distinguished from cytosine (C) in a sample nucleotide sequence. Methods may comprise oxidizing or reducing a first portion of polynucleotides which comprise the sample nucleotide sequence; treating the oxidized or reduced first portion and a second portion of polynucleotides with bisulfite; sequencing the polynucleotides in the first and second portions of the population following steps ii) and iii) to produce first and second nucleotide sequences, respectively and; identifying the residue in the first and second nucleotide sequences which corresponds to a cytosine residue in the sample nucleotide sequence. These methods may be useful, for example in the analysis of genomic DNA and/or of RNA.

Abstract: One or more digital representations of single- (101) and/or few-layer (102) thin-film material are automatically identified robustly and reliably in a digital image (100), the digital image (100) having a predetermined number of color components, by—determining (304) a background color component of the digital image (100) for each color component, and—determining or estimating (306) a color component of thin-film material to be identified in the digital image (100) for each color component by obtaining a pre-determined contrast value (CR; CG; CB) for each color component and multiplying the respective background color component with a numerical difference between the pre-determined contrast value (CR; CG; CB) for a given color component and about 1,—identifying points or parts of the image with all color components being within a predetermined range of the determined or estimated color component.

Abstract: The present invention provides substituted 2-aminopyridines useful in treating cell proliferative disorders.