Patents by Inventor John Brassil
John Brassil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10176887Abstract: Methods for assaying properties in tissues or organs of drugs and other chemical compounds and substances include ex vivo normothermic perfusion with a fluid containing a test substance to obtain data regarding the tissue or organ, the substance and/or an interaction of the substance and the tissue or organ. The data can be used as, for example, part of a submission to a government regulatory organization.Type: GrantFiled: November 14, 2006Date of Patent: January 8, 2019Assignee: ORGAN RECOVERY SYSTEMS, INC.Inventors: John Brassil, Christopher G. Curtis, David Kravitz
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Patent number: 9706769Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures. The methods further include perfusing the organ at hypothermic and/or normothermic temperatures with a second perfusate containing a substance for reacting with the organ. Condition of the organ may be automatically monitored, and the perfusion process can be automatically controlled using a control program.Type: GrantFiled: March 4, 2013Date of Patent: July 18, 2017Assignee: ORGAN RECOVERY SYSTEMS, INCInventors: Michael Taylor, John Brassil
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Patent number: 9661843Abstract: A method for controlling at least one pump in a perfusion apparatus for delivering a fluid to at least one organ through a plurality of vessels for maintaining the viability of the at least one organ, the method including supplying a fluid to a first vessel of an organ and to a second vessel of an organ; measuring a first parameter of the fluid flowing in the first vessel and a second parameter of the fluid flowing in the second vessel; and executing direct control of the second parameter of the fluid flowing in the second vessel to influence the first parameter of the fluid flowing in the first vessel.Type: GrantFiled: March 19, 2015Date of Patent: May 30, 2017Assignee: LIFELINE SCIENTIFIC, INC.Inventor: John Brassil
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Patent number: 9320269Abstract: An organ preservation system having an organ chamber with a perfusate reservoir surrounded by a heat exchanger. The system has a pump for circulating perfusate, which draws perfusate from the reservoir and passes the perfusate through a bubble trap, and temperature and pressure sensors prior to entering the chamber where the organ is perfused. An oxygenator with a platform and a filter is situated within the perfusate reservoir such that perfusate leaving the organ which rests on the platform passes through the filter before dripping into the perfusate reservoir below. The pump re-circulates perfusate from the perfusate reservoir. The oxygenator has gas permeable tubes wound around support legs of the oxygenator. Circulation of oxygen through the tubes allows for gas exchange by diffusion across the membrane to oxygenate perfusate flowing around the tubes.Type: GrantFiled: September 24, 2010Date of Patent: April 26, 2016Inventor: John Brassil
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Publication number: 20160042084Abstract: Methods of monitoring, maintaining, and/or restoring viability of at least one organ in a perfusion apparatus are disclosed. The methods include monitoring data comprising information relating to events occurring while at least one organ is present in a perfusion apparatus to form a data record. And they further include connecting the perfusion apparatus to a network through wiring or wirelessly, and continuously uploading the data record to a database at a location away from the perfusion apparatus in such a manner that a database computer that obtains the data record from the database can at least one of manage, track, monitor, and diagnose the at least one organ in the perfusion apparatus in real-time based upon the information in the data record.Type: ApplicationFiled: October 21, 2015Publication date: February 11, 2016Inventors: Donald R. OWEN, David C. KRAVITZ, John BRASSIL, Kelvin G.M. BROCKBANK, Andrew BURROUGHS, Douglas SCHEIN, Stanley HARRIS, Dennis J. STEIBEL, Richard FRASER, Christopher G. CURTIS
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Publication number: 20150189866Abstract: A method for controlling at least one pump in a perfusion apparatus for delivering a fluid to at least one organ through a plurality of vessels for maintaining the viability of the at least one organ, the method including supplying a fluid to a first vessel of an organ and to a second vessel of an organ; measuring a first parameter of the fluid flowing in the first vessel and a second parameter of the fluid flowing in the second vessel; and executing direct control of the second parameter of the fluid flowing in the second vessel to influence the first parameter of the fluid flowing in the first vessel.Type: ApplicationFiled: March 19, 2015Publication date: July 9, 2015Inventor: John BRASSIL
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Patent number: 8986978Abstract: A system and method for regulating cooperatively the pressures and flows of input vessels such as both the portal vein and hepatic artery for the liver. This invention solves problems of less-than-therapeutic portal vein flow during perfusion preservation by implementing cooperative regulation between the inputs, e.g., portal vein and hepatic artery pumping systems, on an organ preservation apparatus. It includes an algorithm that adapts to the situation wherein the portal vein has reached minimum flow and maximum pressure. The cooperative regulation algorithm senses the problem with the portal vein and solves it by adjusting the hepatic artery flow conditions.Type: GrantFiled: February 29, 2008Date of Patent: March 24, 2015Assignee: Lifeline Scientific, Inc.Inventor: John Brassil
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Patent number: 8962303Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate.Type: GrantFiled: August 10, 2011Date of Patent: February 24, 2015Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Patent number: 8771930Abstract: Properties such as toxicity of substances may be determined by assaying properties, fates and effects of substances in an ex vivo metabolically active human organ or tissue under normothermic perfusion with a fluid containing a test substance. The data can be used as, for example, part of a submission to a government regulatory organization. Preferred methods use perfused endocrine gland organs or tissues to evaluate hormone or other bodily chemical disruption caused by substances and pre-donation diseased or injured organs or tissues.Type: GrantFiled: May 18, 2007Date of Patent: July 8, 2014Assignee: Lifeline Scientific, Inc.Inventors: Gerald Curtis, John Brassil, David Kravitz
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Patent number: 8765364Abstract: Methods of validating results of assessments of test substances using human-derived tissues and/or organs, particularly tissues and/or organs unsuitable for transplantation, include assessing the suitability of the organ and/or tissue for substance testing, as well as inter-organ variability and use of exogenous and/or endogenous controls.Type: GrantFiled: May 18, 2007Date of Patent: July 1, 2014Assignee: Lifeline Scientific, Inc.Inventors: Gerald Curtis, John Brassil, David Kravitz
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Patent number: 8741555Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. During the period in which the organ is preserved and/or maintained, the organ may be additionally be perfused to obtain data regarding the fluid and/or organ. The data may then be used to ultimately provide information regarding the perfusion efficacy and allow for altering of the perfusion parameters.Type: GrantFiled: May 14, 2004Date of Patent: June 3, 2014Assignee: Organ Recovery Systems, Inc.Inventors: John Brassil, Simona Baicu
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Patent number: 8609400Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.Type: GrantFiled: May 12, 2010Date of Patent: December 17, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Publication number: 20130177898Abstract: A method of treating tissue, including organs, with electromagnetic energy to decrease the fat content of the tissue comprises the steps of providing a source of electromagnetic energy, and subjecting adipose cells to the source of electromagnetic energy at hypothermic conditions. The tissue may be harvested and in an isolated state, such as being placed in an organ preservation system. Electromagnetic energy between 600 nm to 700 nm is used for treatment. During treatment, target tissue such as a harvested organ is subject to perfusion.Type: ApplicationFiled: July 5, 2012Publication date: July 11, 2013Inventors: John Brassil, Alan Rhodes
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Patent number: 8445260Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization prevention and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate.Type: GrantFiled: August 10, 2011Date of Patent: May 21, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Douglas Schein, Stanley Harris, Dennis Steibel, Richard Fraser, Dickon Isaacs
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Patent number: 8431385Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: January 21, 2011Date of Patent: April 30, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein
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Patent number: 8420381Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: November 5, 2010Date of Patent: April 16, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Patent number: 8389280Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures. The methods further include perfusing the organ at hypothermic and/or normothermic temperatures with a second perfusate containing a substance for reacting with the organ. Condition of the organ may be automatically monitored, and the perfusion process can be automatically controlled using a control program.Type: GrantFiled: February 17, 2009Date of Patent: March 5, 2013Assignee: Organ Recovery SystemsInventors: Michael John Taylor, John Brassil
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Patent number: 8389271Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied.Type: GrantFiled: December 31, 2009Date of Patent: March 5, 2013Assignee: Organ Recovery Systems, Inc.Inventors: David Walter Wright, Douglas Schein, John Brassil
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Patent number: 8349551Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.Type: GrantFiled: November 5, 2010Date of Patent: January 8, 2013Assignee: Lifeline Scientific, Inc.Inventors: Donald R. Owen, David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Dennis J. Steibel, Richard Fraser, Stanley Harris, Douglas Schein
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Patent number: 8323954Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures.Type: GrantFiled: March 29, 2011Date of Patent: December 4, 2012Assignee: Lifeline Scientific, Inc.Inventors: David C. Kravitz, John Brassil, Kelvin G. M. Brockbank, Andrew Burroughs, Dickon Isaacs, Douglas Schein