Abstract: A system and method for regulating cooperatively the pressures and flows of input vessels such as both the portal vein and hepatic artery for the liver. This invention solves problems of less-than-therapeutic portal vein flow during perfusion preservation by implementing cooperative regulation between the inputs, e.g., portal vein and hepatic artery pumping systems, on an organ preservation apparatus. It includes an algorithm that adapts to the situation wherein the portal vein has reached minimum flow and maximum pressure. The cooperative regulation algorithm senses the problem with the portal vein and solves it by adjusting the hepatic artery flow conditions.

Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures. The methods further include perfusing the organ at hypothermic and/or normothermic temperatures with a second perfusate containing a substance for reacting with the organ. Condition of the organ may be automatically monitored, and the perfusion process can be automatically controlled using a control program.

Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures. The methods further include perfusing the organ at hypothermic and/or normothermic temperatures with a second perfusate containing a substance for reacting with the organ. Condition of the organ may be automatically monitored, and the perfusion process can be automatically controlled using a control program.

Abstract: Methods of validating results of assessments of test substances using human-derived tissues and/or organs, particularly tissues and/or organs unsuitable for transplantation, include assessing the suitability of the organ and/or tissue for substance testing, as well as inter-organ variability and use of exogenous and/or endogenous controls.

Abstract: Properties such as toxicity of substances may be determined by assaying properties, fates and effects of substances in an ex vivo metabolically active human organ or tissue under normothermic perfusion with a fluid containing a test substance. The data can be used as, for example, part of a submission to a government regulatory organization. Preferred methods use perfused endocrine gland organs or tissues to evaluate hormone or other bodily chemical disruption caused by substances and pre-donation diseased or injured organs or tissues.

Abstract: A method is disclosed of transferring data to a first communications device having a first transceiver for communication at a first data rate over a long range, and a second transceiver for communication at a second, higher data rate over a short range. The method includes forming a co-ordinated short-range wireless network using the first communications device and at least one second communications device of a similar type. Communication is then initiated between the first communications device and said at least one second communications device to establish whether that second communications device has data required by the first communications device. The first communications device then communicates, upon the first communications device receiving confirmation that a second communications device has the required data, with a service provider using its first transceiver to request permission for the transfer of the required data from said communications device to the first communications device.

Abstract: A therapy system providing exercise, massage, and medication. The system includes a portable, wearable exercise device with provisions for resistance during range of motion exercises. The system also offers metrics, diagnostics, remote monitoring, massage therapy, and controlled delivery of medication. The therapy system automatically provides information that is useful for determining recommendations for enhancing therapy.

Abstract: An embodiment of a method of and apparatus for maintaining the privacy of a subject of a recording are disclosed. The location of at least one subject is determined. The location of the subject is stored in a database. The location of a recording device when a recording is made is determined. The location of the recording device is provided to the database.

Abstract: A co-operative network includes a first device that advertises resources it has available for sharing and a second device that requests at least part of the available resources of the first device. The devices co-operatively execute a task using the shared resources of the first device and the resources of the second device.

Abstract: The bottle closure comprises a generally cylindrical inner member adapted to be threadedly engaged on the outside of the neck of a bottle. The inner member has a central passage communicating with the neck of the bottle. An outer member is rotatably mounted on and around the inner member. The inner member includes a valve seat defining a fluid passage between the bottle and the outer member and being located within the neck of the bottle. The outer member includes a valve closure element adapted to close the fluid passage in a first annular position of the outer member on the inner member thereby to form a seal with the valve seat. The outer member, when moved to a second annular position relative to the inner member, opens the fluid passage, thereby to allow fluid in a bottle to flow through the closure.

Abstract: Methods of streaming data, and systems thereof, are described. Data encoded at a first encoding rate is streamed at a first transmission rate. The first encoding rate corresponds to a first playback rate. The first transmission rate is increased by an incremental amount to an intermediate transmission rate that is greater than the first playback rate. The intermediate transmission rate is then increased to a second transmission rate that corresponds to a second encoding rate. The data encoded at the first encoding rate is streamed at the second transmission rate. A determination is made whether there is network bandwidth sufficient for the second transmission rate. If so, data encoded at a second encoding rate is streamed at the second transmission rate in place of the data encoded at the first encoding rate.

Abstract: The bottle closure comprises a generally cylindrical inner member adapted to be threadedly engaged on the outside of the neck of a bottle. The inner member has a central passage communicating with the neck of the bottle. An outer member is rotatably mounted on and around the inner member. The inner member includes a valve seat defining a fluid passage between the bottle and the outer member and being located within the neck of the bottle. The outer member includes a valve closure element adapted to close the fluid passage in a first annular position of the outer member on the inner member thereby to form a seal with the valve seat. The outer member, when moved to a second annular position relative to the inner member, opens the fluid passage, thereby to allow fluid in a bottle to flow through the closure.

Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. During the period in which the organ is preserved and/or maintained, the organ may be additionally be perfused to obtain data regarding the fluid and/or organ. The data may then be used to ultimately provide information regarding the perfusion efficacy and allow for altering of the perfusion parameters.

Abstract: WAN link preferences for subflows of an application flow are determined. The characteristics of WAN links operable to transmit the subflows are also determined. The WAN link preferences are compared to the WAN link characteristics, and the subflows are assigned to the WAN links based on the comparison.

Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures. The methods further include perfusing the organ at hypothermic and/or normothermic temperatures with a second perfusate containing a substance for reacting with the organ. Condition of the organ may be automatically monitored, and the perfusion process can be automatically controlled using a control program.

Abstract: The bottle closure comprises a generally cylindrical inner member adapted to be threadedly engaged on the outside of the neck of a bottle. The inner member has a central passage communicating with the neck of the bottle. An outer member is rotatably mounted on and around the inner member. The inner member includes a valve seat defining a fluid passage between the bottle and the outer member and being located within the neck of the bottle. The outer member includes a valve closure element adapted to close the fluid passage in a first annular position of the outer member on the inner member thereby to form a seal with the valve seat. The outer member, when moved to a second annular position relative to the inner member, opens the fluid passage, thereby to allow fluid in a bottle to flow through the closure.

Abstract: A method of transferring high rate data between a first communications device (32) and a second communications device (1) is disclosed. The second communications device (1) has a first transceiver (4) for communication with the first communications device (32) at a first, low data rate over a long range, and a second transceiver (2) for communicating at a second, high data rate over a short range. The method comprises the steps of forming a coordinated short-range network (piconet) using the second communications device (1) and a plurality of other similar communications devices (11, 21), transferring a portion of said data to or from the first communications device (32) from or to each of said second communications device and said other communications devices using their first transceivers (2, 12, 22), and transferring said data portions between said other communications devices and the second communications device using their second transceivers (4, 14, 24).

Abstract: The present teachings provide for the download and purchase of a digital movie. Several schemes are described for handling a large file that is a digital movie including separately handling its audio and video component. Because the video component is downloaded separately from an audio component, it can be downloaded over several sessions. A user can separately initiate the download of the corresponding audio component. Because the audio component is significantly smaller, its download can be achieved in a much shorter time, often in one session. Thus, content is provided to a user in a substantially transparent manner such that a user's perception of receiving the functionality of a digital movie essentially becomes the time required to initiate payment and download of a relatively small audio component.

Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied.

Abstract: An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygenated cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. During the period in which the organ is preserved and/or maintained, various drug research and development may be performed on and/or with the organ.