Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

Abstract: A fluid end 15 for a multiple reciprocating pump assembly 12 comprises at least three plunger bores 61 or 91, each for receiving a reciprocating plunger 35. Each plunger bore has a plunger bore axis 65 or 95. The plunger bores are arranged across the fluid end to define a central plunger bore and lateral plunger bores located on either side of the central plunger bore. The fluid end 15 also comprises at least three respective suction valve bores 59 or 89 in fluid communication with the plunger bores. Each suction valve bore can receive a suction valve 41 and has a suction valve bore axis 63 or 93. The fluid end 15 also comprises at least three respective discharge valve bores 57 or 87 in fluid communication with the plunger bores. Each discharge valve bore can receive a discharge valve 43 and has a discharge valve bore axis 63 or 93. At least one of the axes of at least one of the suction and discharge valve bores is offset in the fluid end from its respective plunger bore axis.

Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, depositing a primer compound on a substrate, thereby forming a primed substrate, contacting the primed substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated primed substrate, and contacting the trihydroxyphenyl-treated primed substrate with a solution of an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the primed substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate.

Abstract: A method for fast remote communication and computation between processors is provided in the illustrative embodiments. A direct core to core communication unit (DCC) is configured to operate with a first processor, the first processor being a remote processor. A memory associated with the DCC receives a set of bytes, the set of bytes being sent from a second processor. An operation specified in the set of bytes is executed at the remote processor such that the operation is invoked without causing a software thread to execute.

Abstract: A method for improving the performance of a digital circuit is provided in the illustrative embodiments. A real frequency of operation of the digital circuit is adjusted using a control loop in the digital circuit, the adjusting the real frequency being responsive to a change in an operating condition of the digital circuit. A measurement of a current drawn by the digital circuit is received from a voltage regulator supplying electrical power to the digital circuit. An over-current target current value is received. A voltage output from the voltage regulator to the digital circuit is adjusted such that the current drawn by the digital circuit does not exceed the over-current target current value.

Abstract: Methods for processing substrate surfaces comprising metallic nanoparticles are disclosed. The methods involve providing a substrate surface comprising metallic nanoparticles, and exposing the substrate surface to a plasma.

Abstract: Charge pump circuits having circuit components such as transistors which may be damaged by voltage transients greater than the normal operating voltage levels of the charge pump circuit, such as may be experienced during powering down. The circuit components to be protected are connected in parallel with a leakage element arranged to have a leakage current that is small enough during normal operation to allow the charge pump to operate effectively but which is large enough, during development of a voltage transient, to prevent excess voltage levels being achieved. The leakage element may have a significant leakage current at a voltage less than the breakdown voltage of the circuit component. Suitable leakage elements are poly diodes.

Abstract: A system, and computer program product for increasing a capacity of a memory are provided in the illustrative embodiments. Using an application executing using a processor wherein the memory includes a set of ranks, the memory is configured to form a cold tier and a hot tier, the cold tier including a first subset of ranks from the set of ranks in the memory, and the hot tier including a second subset of ranks from the set of ranks in the memory. A determination is made whether a page to which a memory access request is directed is located in the cold tier in the memory. In response to the page being located in the cold tier of the memory, the processing of the memory access request is throttled by processing the memory access request with a delay.

Abstract: A method for increasing a capacity of a memory is provided in the illustrative embodiments. Using an application executing using a processor wherein the memory includes a set of ranks, the memory is configured to form a cold tier and a hot tier, the cold tier including a first subset of ranks from the set of ranks in the memory, and the hot tier including a second subset of ranks from the set of ranks in the memory. A determination is made whether a page to which a memory access request is directed is located in the cold tier in the memory. In response to the page being located in the cold tier of the memory, the processing of the memory access request is throttled by processing the memory access request with a delay.

Abstract: An apparatus for the detection of dental caries on the surface of a remaining tooth present underneath a crown are provided. Such an inventive concept involves the utilization of a proper electrically conductive pathway from the crown exterior to the tooth itself, allowing for impedance measurements to be undertaken to determine the degree of potential demineralization within the tooth and/or adhesive loss at the tooth/crown interface, all due to decay attributable to dental caries or like problems. A measuring electrode may be applied to a specific point on the target crown as well as on the adjacent gum, to measure impedance levels for any appreciable decreases which would indicate underlying tooth decay has been initiated. From that point, the dental professional may undertake proper therapeutic measures to treat such tooth locations in order to avoid far more expensive repairs, such as the implementation of bridges or implants.

Abstract: A scanning system for use in an imaging apparatus includes a first light source and a second light source for emitting light beams for generating an image. A driver circuitry has first and second outputs connected to the first and second light sources, respectively, for controlling the first and second light sources. A signal transmitter includes a first interface for communicating a clock signal to the driver circuitry and a second interface for communicating an image information signal to the driver circuitry. During a clock cycle of the clock signal, the driver circuitry captures a first bit information from the image information signal at a rising edge of the clock signal and a second bit information from the image information signal at a falling edge of the clock signal. Thereafter, the driver circuitry drives the first and second light sources based on the first and second bit information captured, respectively.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Abstract: A method, system, and computer program product for compacting a non-biased results multiset are provided in the illustrative embodiments. A set of references and a multiset of values are identified. The multiset includes a first and a second set of values, each set including a first value. A first reference in the set of references refers to the first set of values and a second reference in the set of references refers to the second set of values. The values in the first and second set of values are re-arranged to form permuted first and second sets of values. The multiset is compacted by overlaying the permuted first and second sets of values in a portion such that the permuted first set of values and the permuted second set of values share a single instance of the first value in a portion of the compacted multiset.

Abstract: A fluid end 15 for a multiple reciprocating pump assembly 12 comprises at least three plunger bores 61 or 91, each for receiving a reciprocating plunger 35. Each plunger bore has a plunger bore axis 65 or 95. The plunger bores are arranged across the fluid end to define a central plunger bore with lateral plunger bores located on either side. The fluid end 15 also comprises at least three respective suction valve bores 59 or 89 in fluid communication with the plunger bores. Each suction valve bore can receive a suction valve 41 and has a suction valve bore axis 63 or 93. The fluid end 15 also comprises at least three respective discharge valve bores 57 or 87 that can receive a discharge valve 43 and are in fluid communication with the plunger bores. Axes of suction and discharge valve bores are offset in the fluid.

Abstract: An open mesh insect control material is described which includes an insect contact surface, an internal surface, apertures communicating both surfaces and a plurality of filamentous projections protruding from the insect contact surface the projections at least partly occlude the apertures. The structure is suitable for use in pest control especially as a mosquito net.

Abstract: A service provider system enables a subscriber to purchase services over a network from a service provider for the benefit of third parties located in different locations. The service provider system provides service flexibility by allowing parameters to be set, such as place and time of service delivery. Further, conditions allowing third-party recipients to change service parameters include delivery time and place, exchange of purchased service for another service, return of the purchased service, etc. Reporting options to both the subscriber and the third party can additionally be provided. Reporting messages or notifications may be sent to the purchasing subscriber to indicate which of the third parties had taken advantage of the purchased service, when and where the service was consumed, and/or what the actual cost of delivering the service was. The service provider system can also provide incentives for third parties to take advantage of the purchased service.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.

Abstract: A machine-readable medium and a network device are provided for speech-to-text translation. Speech packets are received at a broadband telephony interface and stored in a buffer. The speech packets are processed and textual representations thereof are displayed as words on a display device. Speech processing is activated and deactivated in response to a command from a subscriber.

Abstract: A method in one embodiment includes forming a layer of a nonmagnetic material above an upper surface of a substrate; forming a resist structure above the layer of nonmagnetic material, wherein the resist structure has an undercut; removing a portion of the layer of nonmagnetic material not covered by the resist structure; depositing a layer of magnetic material above the substrate adjacent a remaining portion of the layer of nonmagnetic material such that at least portions of the layer of magnetic material and the remaining portion of the layer of nonmagnetic material lie in a common plane; removing the resist structure; and forming a write pole above the layer of magnetic material and the remaining portion of the layer of nonmagnetic material. Additional methods are also presented.

Abstract: A machine-readable medium and a network device are provided for speech-to-text translation. Speech packets are received at a broadband telephony interface and stored in a buffer. The speech packets are processed and textual representations thereof are displayed as words on a display device. Speech processing is activated and deactivated in response to a command from a subscriber.