Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.

Abstract: The invention relates to improving the movement of a target polynucleotide with respect to a transmembrane pore when the movement is controlled by a polynucleotide binding protein. The invention also relates to improved transmembrane pores and polynucleotide binding proteins.

Abstract: The invention provides methods of immobilizing an active agent to a substrate surface, including the steps of, providing a substrate, contacting the substrate with a solution of a compound including a trihydroxyphenyl group, thereby forming a trihydroxyphenyl-treated substrate, and contacting the trihydroxyphenyl-treated substrate with an active agent, thereby immobilizing the active agent on the substrate. Further provided are methods of immobilizing an active agent on a substrate, including the steps of providing a substrate, combining a solution of a compound including a trihydroxyphenyl group with a solution of an active agent, thereby forming a solution of an active agent-trihydroxyphenyl conjugate, and contacting the substrate with the solution of the active agent-trihydroxyphenyl conjugate, thereby immobilizing the active agent on the substrate. The invention further provides substrates and medical device or device components with active agents immobilized on the surface thereof.

Abstract: Technologies are generally described for optical image diversion to provide image capture and display from one or more directions using an image sensor. In some examples, an optical assembly may be used to receive light or other electromagnetic radiation from multiple (including opposing) directions and to provide light or other electromagnetic radiation to an image sensor or detector to capture images. The optical assembly may be centrally-aligned or offset. The optical assembly may be configured to allow collection of light or other electromagnetic radiation from two or more locations. An auto focus or stabilization element may be integrated into one or more optical paths inside an optical switching device. In other examples, a conical or spherical element may be employed to allow capture of panoramic/360 degree images or video. Elements may also be stacked.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.

Abstract: The invention relates to mutant forms of lysenin. The invention also relates to analyte characterisation using the mutant forms of lysenin.

Abstract: Methods and systems of applying retroactive adjustments to financial data. An example method includes: receiving one or more adjustment records associated with a financial account; saving a snapshot of the financial account, the snapshot comprising a plurality of transaction records reflecting previously processed transactions associated with the financial account; merging the adjustment records and the transaction records to produce a plurality of adjusted transaction records; processing adjusted transaction records to produce an updated state of the financial account; comparing the saved snapshot to the updated state of the financial account to produce one or more adjustment events; and processing the adjustment events using one or more event processing rules.

Abstract: This applications relates to methods and apparatus for monitoring a socket (101), to detect a connection status of a mating plug (102), e.g. for monitoring an audio jack socket for connection of an audio jack plug. A monitor (115, 305) is configured to monitor a voltage (VM) at a monitoring node (114), which is coupled to a jack detect contact (112) of the socket and a voltage pull-up element (113). The voltage (VM) at the monitoring node (114) is monitored against a threshold (Vthv) and a threshold module (302) is configured to vary the threshold depending on an indication of signal activity (SACT) of a signal path for a first socket contact (103) which will be electrically connected to the jack detect contact when a plug when inserted in the socket.

Abstract: Methods, systems, and techniques for analyzing the level of engagement of viewers of shared digital displays and enhancing that engagement by dynamically modifying the content of the display and incorporating personalized content created by viewers are provided. One example embodiment is the Dynamic Content Analysis and Engagement System (DCAES), which enables the operator of the system to analyze engagement, generate metrics, manage owner and viewer generated content, and dynamically modify the content on the shared display to increase the engagement of the viewer. In one example embodiment, the DCAES comprises an attention sensor module, an analysis module, a content management module, and a display control module.

Abstract: A method of sending information between first and second modules connected by a signal bus comprises generating a clock signal in the first module, and imposing the clock signal on a first line of the bus. A first pattern of bit values is transmitted from the second module to the first module on a second line of the bus, during first half-periods of each period of said clock signal. A second pattern of bit values is transmitted from the first module to the second module on the second line of the bus, during second half-periods of each period of said clock signal, wherein the second half-periods of each period of said clock signal are different from the first half-periods of each period of said clock signal. Information can then be transmitted from the first module to the second module by altering the second pattern of bit values; and information can be transmitted from the second module to the first module by altering the first pattern of bit values.

Abstract: The present invention provides a connection device or tool (10, 110, 210, 310, 410, 510, 610, 1110, 2110, 3110, 4110) to connect a first tool (80, 90) to a second tool (90,80), the connection device or tool (10, 110, 210, 310, 410, 510, 610, 1110, 2110, 3110, 4110) comprising at least one shell member 30 which clamps a first end to said first tool (80, 90) and a second end of said at least one shell member 30 to engage with said second tool (90,80), whereby relative rotation between said first tool and second tool is prevented, and axial separation of said first tool (80, 90) and second tool (90,80) is prevented or is assisted in being prevented. This results in a safer combination of the first tool (80, 90) and second tool (90,80), and allows for a one handed operation of the combination.

Abstract: An artificial or modified natural blood flow tubing has a helical-flow inducer to induce helical flow in such a fashion as to eliminate or reduce turbulence. One inducer is a tubular stent of expansible mesh having a helical vane.

Abstract: Methods of generating oligosaccharides are provided.

Abstract: The present invention provides a connection device or tool (10, 110, 210, 310, 410, 510, 610, 1110, 2110, 3110, 4110) to connect a first tool (80, 90) to a second tool (90,80), the connection device or tool (10, 110, 210, 310, 410, 510, 610, 1110, 2110, 3110, 4110) comprising at least one shell member 30 which clamps a first end to said first tool (80, 90) and a second end of said at least one shell member 30 to engage with said second tool (90,80), whereby relative rotation between said first tool and second tool is prevented, and axial separation of said first tool (80, 90) and second tool (90,80) is prevented or is assisted in being prevented. This results in a safer combination of the first tool (80, 90) and second tool (90,80), and allows for a one handed operation of the combination.

Abstract: An imaging device has a photoconductor with a surface that is selectively discharged by a light from a laser diode to create a latent electrostatic image for attracting toner for transfer to a media. A circuit drives the laser diode. The circuit has a switch for turning on and off the light, a resistor complementary to the laser diode selectively connectable to the switch, and a passive circuit component coupled to the laser diode. The passive circuit component is a delay line, inductor, choke, coiled wire, or ferrite bead is contemplated. It may also typify a length of copper tracing on a printed circuit board that supports the laser diode. The circuit causes an initial overshoot voltage spike in an on voltage pulse that is about 20% or more than the settled on voltage. The voltage spike dampens out in about one-fourth of a total voltage on time of the pulse.

Abstract: An imaging device has a photoconductor with a surface that is selectively discharged by a light from a laser diode to create a latent electrostatic image for attracting toner for transfer to a media. A circuit drives the laser diode. The circuit has a switch for turning on and off the light, a resistor complementary to the laser diode selectively connectable to the switch, and a passive circuit component coupled to the laser diode. The passive circuit component is a delay line, inductor, choke, coiled wire, or ferrite bead is contemplated. It may also typify a length of copper tracing on a printed circuit board that supports the laser diode. The circuit causes an initial overshoot voltage spike in an on voltage pulse that is about 20% or more than the settled on voltage. The voltage spike dampens out in about one-fourth of a total voltage on time of the pulse.

Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.

Abstract: A method, system, and computer program product for on-chip control of thermal cycling in an integrated circuit (IC) are provided in the illustrative embodiments. A first circuit is configured on the IC for adjusting a first voltage being applied to a first part of the IC. A first temperature of the first part is measured at a first time. A determination is made that the first temperature is outside a temperature range defined by an upper temperature threshold and a lower temperature threshold. The first voltage is adjusted by reducing the first voltage when the first temperature exceeds the upper temperature threshold and by increasing the first voltage when the first temperature is below the lower temperature threshold, thereby causing the first temperature of the first part to attain a value within the temperature range.

Abstract: In certain aspects, a digital circuit comprises a delay line to generate a plurality of delayed versions of an input clock. The digital circuit also comprises selection circuitry to provide a selected one of the plurality of delayed versions of the input clock based on a clock selection signal and feedback circuitry to generate the clock selection signal based on the selected one of the plurality of delayed versions of the input clock and based on the input clock. The clock selection signal is further used for selecting and generating other clocks and/or for variation control.

Abstract: A method of sending information between first and second modules connected by a signal bus comprises generating a clock signal in the first module, and imposing the clock signal on a first line of the bus. A first pattern of bit values is transmitted from the second module to the first module on a second line of the bus, during first half-periods of each period of said clock signal. A second pattern of bit values is transmitted from the first module to the second module on the second line of the bus, during second half-periods of each period of said clock signal, wherein the second half-periods of each period of said clock signal are different from the first half-periods of each period of said clock signal. Information can then be transmitted from the first module to the second module by altering the second pattern of bit values; and information can be transmitted from the second module to the first module by altering the first pattern of bit values.