Abstract: A method and apparatus is disclosed for separating an amount of a perfluoroalkyl or polyfluoroalkyl substance (PFAS) from water which is contaminated with the substance. The method comprises the steps of: admitting an amount of the water, which includes an initial concentration of the substance, into a chamber via an inlet thereinto, and introducing a flow of gas into the chamber. The introduced gas induces the water in the chamber to flow, and produces a froth layer which is formed at, and which rises above, an interface with the said flow of water and of introduced gas in the chamber. The froth layer includes an amount of water, and also a concentrated amount of the substance in comparison compared with its initial concentration. The step of removal of at least some of the froth layer from an upper portion of the chamber occurs.

Abstract: A method of separating trace amounts of amphiphilic substances from water which is contaminated with the substances, the method comprising the steps of: admitting an amount of the water, which includes an initial concentration of the substances, into a chamber via an inlet thereinto: —introducing a flow of gas into the chamber, wherein said introduced gas induces the water in the chamber to flow, and produces a froth layer which is formed at, and which rises above, an interface with the said flow of—controlling the water content of the froth layer which rises above the interface to influence the concentration of the substances therein; and—removing at least some of the froth layer from an upper portion of the chamber.

Abstract: Apparatus is disclosed for separating an amount of a substance from groundwater, comprising an elongate chamber (18) having an inlet (22) which is arranged in use to admit groundwater into the chamber near a lower first end (24). There is also a gas sparger (26) located near the first end (24) which admits gas into the chamber for inducing groundwater to flow from the first end (24) of the chamber toward a second end upper end, and for producing a froth layer (32) which rises above an interface with the groundwater including a concentrated amount of the substance. A suction hood (38) can be moved downward from the top of the chamber (18) into a position to collapse the froth layer (32) and to cause it to be removed from the well body (14). The suction hood (38) (acting as a froth depth regulation device) controls the amount of groundwater in the froth layer (32), which influences the concentration of the contaminant substance achieved in the froth layer (32).

Abstract: The present disclosure discusses a method of manufacturing an implantable neural electrode. The method includes cutting a metal layer to form a plurality of electrode sites, contact pads and metal traces connecting the electrode sites to the contact pads. A first silicone layer including a mesh is formed and coupled to the metal layer. A second silicone layer is formed and laminated to the first silicone layer coupled with the metal layer. Holes are formed in the first or second silicone layer exposing the contact pads and electrode sites. Wires are welded to the exposed contact pads and a third layer of silicone is overmolded over the contact pads and wires.

Abstract: A substrate container includes a container portion having an open side or bottom, and a door to sealingly close the open side or bottom, one of the door and the container portion defining access structure. The substrate container additionally includes a check-valve assembly, the check-valve assembly being retained with respect to the access structure to provide fluid communication with an interior of the substrate container. The check-valve assembly includes a grommet, the grommet being formed of an elastomeric material. A valve seat is disposed within the grommet, the valve seat being integrally formed with the grommet according to one aspect, and being formed of a separate piece according to another aspect. An elastomeric valve member, specifically an elastomeric umbrella valve member according to one aspect, is disposed within the grommet and held to engage the valve seat, thereby restricting fluid flow through the check-valve assembly with respect to the interior of the substrate container.

Abstract: An approach is described for securely and automatically handling credentials when used for accessing endpoints, and/or applications and resources on the endpoints. The approach involves selecting and injecting credentials at an endpoint by an accessor to log into the endpoint, running applications or gaining access to resources on the endpoint, without full credential information traversing the accessor's machine.

Abstract: A privilege access management (PAM) appliance can receive an access request from an accessor device to access an endpoint device. The PAM appliance can establish a session via a secure connection between the accessor device and the endpoint device. The PAM appliance can transmit a request for credential information available for the accessor device to access the endpoint device from a credential management device. The credential management device can receive the request for credential information available for the accessor device to access the endpoint device. The credential management device can extract a set of credentials that are available for the accessor device from a plurality of credentials. The credential management device can provide at least one of the set of credentials to the endpoint device for the accessor device for the session.

Abstract: Fluid delivery devices, systems and methods. The fluid delivery devices may be used to delivery fluid (e.g., insulin) to a user. The devices may have one or more inlets, and may be configured for use with an injection device, such as a syringe, and/or with a pump.

Abstract: The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Abstract: The present invention relates to methods and kits for identifying microsatellite instability (MSI) in a sample. In particular it relates to identifying microsatellite instability in a tumor sample, which may be from a subject suspected of having colorectal cancer or Lynch syndrome. The methods and kits can be used to identify mismatch repair defects. More particularly the invention relates to a panel of markers for a sequencing based MSI test, that can differentiate between MSI-H and MSS CRCs. The invention also allows for determination of biological significance, differentiating between PCR and sequencing errors and MSI induced indels/mutations.

Abstract: Apparatus is disclosed for separating an amount of a substance from groundwater, comprising an elongate chamber (18) having an inlet (22) which is arranged in use to admit groundwater into the chamber near a lower first end (24). There is also a gas sparger (26) located near the first end (24) which admits gas into the chamber for inducing groundwater to flow from the first end (24) of the chamber toward a second end upper end, and for producing a froth layer (32) which rises above an interface with the groundwater including a concentrated amount of the substance. A suction hood (38) can be moved downward from the top of the chamber (18) into a position to collapse the froth layer (32) and to cause it to be removed from the well body (14). The suction hood (38) (acting as a froth depth regulation device) controls the amount of groundwater in the froth layer (32), which influences the concentration of the contaminant substance achieved in the froth layer (32).

Abstract: The present invention includes a safety apparatus and method for protecting users during maintenance operations for a rotorcraft comprising: at least one permanent, semi-permanent, or detachable safety bar, strap, fastener, hook, or loop that is attached or attachable to a rotorcraft, wherein the safety bar, strap, fastener, hook, or loop is positioned in an area or surface between a windshield of the rotorcraft and a tail boom of the rotorcraft and is connectable to a user safety device to provide fall protection from the area or surface.

Abstract: The present invention relates to phenyl amino pyrimidine compounds which are inhibitors of protein kinases including JAK kinases. In particular the compounds are selective for JAK2 kinases. The kinase inhibitors can be used in the treatment of kinase associated diseases such as immunological and inflammatory diseases including organ transplants; hyperproliferative diseases including cancer and myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases.

Abstract: The present invention includes a safety apparatus and method for protecting users during maintenance operations for a rotorcraft comprising: at least one permanent, semi-permanent, or detachable safety bar, strap, fastener, hook, or loop that is attached or attachable to a rotorcraft, wherein the safety bar, strap, fastener, hook, or loop is positioned in an area or surface between a windshield of the rotorcraft and a tail boom of the rotorcraft and is connectable to a user safety device to provide fall protection from the area or surface.

Abstract: The present disclosure discusses a method of manufacturing an implantable neural electrode. The method includes cutting a metal layer to form a plurality of electrode sites, contact pads and metal traces connecting the electrode sites to the contact pads. A first silicone layer including a mesh is formed and coupled to the metal layer. A second silicone layer is formed and laminated to the first silicone layer coupled with the metal layer. Holes are formed in the first or second silicone layer exposing the contact pads and electrode sites. Wires are welded to the exposed contact pads and a third layer of silicone is overmolded over the contact pads and wires.

Abstract: An approach is described for securely and automatically handling credentials when used for accessing endpoints, and/or applications and resources on the endpoints, and more particularly accessing web endpoints and/or web applications and resources on the web endpoints. The approach involves selecting and injecting credentials at an endpoint by an accessor and/or protocol agent to log into the endpoint, running applications, or gaining access to resources on the endpoint, without full credential information traversing the accessor's machine.

Abstract: A substrate container includes a container portion having an open side or bottom, and a door to sealingly close the open side or bottom, one of the door and the container portion defining access structure. The substrate container additionally includes a check-valve assembly, the check-valve assembly being retained with respect to the access structure to provide fluid communication with an interior of the substrate container. The check-valve assembly includes a grommet, the grommet being formed of an elastomeric material. A valve seat is disposed within the grommet, the valve seat being integrally formed with the grommet according to one aspect, and being formed of a separate piece according to another aspect. An elastomeric valve member, specifically an elastomeric umbrella valve member according to one aspect, is disposed within the grommet and held to engage the valve seat, thereby restricting fluid flow through the check-valve assembly with respect to the interior of the substrate container.

Abstract: A semiconductor wafer container assembly includes a container defining an exterior and defining an interior having a wafer storage area adapted to support one or more semiconductor wafers. The container also defines an opening in the container between the exterior and the interior. The container has a door and a latching mechanism to sealingly secure the door closed, and the door is openable for access to the wafer storage area. A passive getter module is removably secured with respect to the exterior of the container by substantially rigid connection structure that is a part of or extends from substantially rigid getter module housing. Getter material is disposed within the housing to decrease concentration of contaminants within the wafer storage area of the container via the access opening and the opening in the container.

Abstract: A sock orthotic includes a sock portion that surrounds and engages at least a portion of a foot, and an orthotic portion that can be situated substantially adjacent to a plantar aspect of the foot. The orthotic portion is integrally affixed to the sock portion to avoid slippage. The sock portion defines a lower opening and an upper opening relative to the plantar aspect, and the orthotic portion is affixed to the sock portion at a perimeter of the lower opening defined by the sock portion.

Abstract: Apparatus and methods for detecting and identifying a cause of a hot-switching event in an automated test system. One or more antennae positioned near mechanical relays in the system may be used to sense electromagnetic radiation. The antennae may be configured to respond to electromagnetic radiation of the type generated during a hot-switching event. Signals measured by the antennae may be processed to determine whether the signals have characteristics of hot-switching events. Processing may entail generating a signal envelope and determining whether the envelope has characteristics indicative of a hot-switching event. When a hot-switching event is detected, information to correlate the event to other events in the test system may also be captured. That information may be time information, enabling program test-system program instructions executing at the time of the event to be identified, such that the test system may be reprogrammed to avoid hot-switching events.