Abstract: Provided herein is a method of isolating cellular components from at least one region of interest in a planar tissue section.

Abstract: Provided herein are structures and methods for isolating cellular components from at least one region of interest in a planar tissue section. Structures and methods as described can allow for isolation and tagging of tissue regions.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present disclosure provides systems, methods, and devices for the simultaneous determination of a single cell's response to a stimuli and characterization of its cell response. The present disclosure further provides methods for detection of disease state, clinical management of a subject suffering from a disease, drug screening, prediction of drug response, and stands to help direct drug and diagnostic development for the treatment of disease.

Abstract: One embodiment describes a network system. The system includes a primary enclosure including a network switch system that includes a plurality of physical interface ports. A first one of the plurality of physical interface ports is to communicatively couple to a network. The system further includes a sub-enclosure comprising a network interface card (NIC) to which a computer system is communicatively coupled and a downlink extension module (DEM) that is communicatively coupled with the NIC and a second one of the plurality of physical interface ports of the network switch system to provide network connectivity of the computer system to the network via the network switch system.

Abstract: Provided herein is a method of isolating cellular components from at least one region of interest in a planar tissue section.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

Abstract: One embodiment describes a network system. The system includes a primary enclosure including a network switch system that includes a plurality of physical interface ports. A first one of the plurality of physical interface ports is to communicatively couple to a network. The system further includes a sub-enclosure comprising a network interface card (NIC) to which a computer system is communicatively coupled and a downlink extension module (DEM) that is communicatively coupled with the NIC and a second one of the plurality of physical interface ports of the network switch system to provide network connectivity of the computer system to the network via the network switch system.

Abstract: One embodiment describes a network system. The system includes a primary enclosure including a network switch system that includes a plurality of physical interface ports. A first one of the plurality of physical interface ports is to communicatively couple to a network. The system further includes a sub-enclosure comprising a network interface card (NIC) to which a computer system is communicatively coupled and a downlink extension module (DEM) that is communicatively coupled with the NIC and a second one of the plurality of physical interface ports of the network switch system to provide network connectivity of the computer system to the network via the network switch system.

Abstract: An instrument access device comprises first, second and third instrument seals for sealing around instruments extended through the device. The seals have respective connector sleeves. Each sleeve connects a base to one of the instrument seals. The device also comprises two insufflation/desufflation ports. Each of the ports comprises a connector extending from the base, a tube extending from the connector, a luer connector and a removable cap. The luer connector is used for connection to any suitable supply line for insufflation gas or for discharge if insufflation gas. In use, the insufflation/desufflation ports facilitate independent control of insufflation and desufflation as may be required during a surgical procedure. Access sleeve at the proximal end is cut-off, folded over the inner proximal ring and is held in place between the base and the inner proximal ring when the base is fitted.

Abstract: A seal comprises a first sealing member and a second sealing member. The sealing members each have an accessway to facilitate access from one side of the sealing member to the other side of the sealing member. The accessways are offset to facilitate sealed access of an object through the sealing members.

Abstract: A wound protector and retractor device 1 comprises a sleeve 2, a distal member provided by a distal ring 3 of resilient material and a proximal member provided by a proximal ring 4. The sleeve 2 is led around the ring 3 and is free to move axially relative to the distal ring 3 somewhat in the manner of a pulley. The proximal ring 4 is fixed to the sleeve 2, in this case at the proximal inner end thereof. The sleeve 2 terminates in a handle or gripping portion which is reinforced by a gripping ring 15. The sleeve extends from the proximal ring 4 and the distal ring 3 is contained between inner and outer layers 2a, 2b of the sleeve 2. The resilient distal ring 3 is scrunched up and inserted through the incision 6. The sleeve 2 is then pulled upwardly. On pulling of the sleeve 2 upwardly the outer layer 2b is pulled up while the inner layer 2a is drawn around the proximal ring 3.

Abstract: One embodiment describes a network system. The system includes a primary enclosure including a network switch system that includes a plurality of physical interface ports. A first one of the plurality of physical interface ports is to communicatively couple to a network. The system further includes a sub-enclosure comprising a network interface card (NIC) to which a computer system is communicatively coupled and a downlink extension module (DEM) that is communicatively coupled with the NIC and a second one of the plurality of physical interface ports of the network switch system to provide network connectivity of the computer system to the network via the network switch system.

Abstract: The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.