Patents by Inventor John C. Drach
John C. Drach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220002335Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: ApplicationFiled: January 27, 2021Publication date: January 6, 2022Inventors: John Henry BOUGHER, III, Ramamurty V S CHANGALVALA, Aaron Leigh DOWNEY, John C. DRACH, Ernest Randall LANIER, JR., Andrew Louis MCIVER, Bradley David ROBERTSON, Dean Wallace SELLESETH, Phiroze Behram SETHNA, Leroy TOWNSEND, Roy W. WARE
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Patent number: 10941175Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: GrantFiled: August 6, 2019Date of Patent: March 9, 2021Assignees: Chimerix, Inc., The Regents of the University of MichiganInventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
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Publication number: 20200199167Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: ApplicationFiled: August 6, 2019Publication date: June 25, 2020Inventors: John Henry BOUGHER, III, Ramamurty V S CHANGALVALA, Aaron Leigh DOWNEY, John C. DRACH, Ernest Randall LANIER, Jr., Andrew Louis MCIVER, Bradley David ROBERTSON, Dean Wallace SELLESETH, Phiroze Behram SETHNA, Leroy TOWNSEND, Roy W. WARE
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Patent number: 10407457Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: GrantFiled: May 18, 2017Date of Patent: September 10, 2019Assignees: Chimerix, Inc., The Regents of the University of MichiganInventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
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Publication number: 20170253628Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: ApplicationFiled: May 18, 2017Publication date: September 7, 2017Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, JR., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
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Patent number: 9708359Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: GrantFiled: August 8, 2016Date of Patent: July 18, 2017Assignees: Chimerix, Inc., The Regents of the University of MichiganInventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
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Patent number: 9701706Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: GrantFiled: November 22, 2016Date of Patent: July 11, 2017Assignees: Chimerix, Inc., The Regents of the University of MichiganInventors: John Henry Bougher, III, Ramamurty V S Changalvala, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
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Publication number: 20170137454Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.Type: ApplicationFiled: November 22, 2016Publication date: May 18, 2017Inventors: Roy W. Ware, Leroy Townsend, John C. Drach
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Patent number: 9174990Abstract: Compounds which are active against viruses have the following Formulas: wherein B is 2-aminopurine-9-yl, which may be unsubstituted or substituted in the 6 position with NHR1, OR2, or SR3; R1 is selected from the group consisting of alkyl, alkenyl, alkynyl, and C4-18 cycloalkyl, any of which may be optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl; R2 is selected from the group consisting of C2-18 alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl, and aryl; and R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, and cycloalkyl, any of which may be branched or unbranched and optionally substituted with one or more members of the group consisting of hydroxy, halo, amino, acyl, cycloalkyl, heterocyclyl and aryl.Type: GrantFiled: February 15, 2007Date of Patent: November 3, 2015Assignees: WAYNE STATE UNIVERSITY, THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Jiri Zemlicka, John C. Drach, Xinchao Chen
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Publication number: 20120270827Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.Type: ApplicationFiled: June 11, 2012Publication date: October 25, 2012Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Leroy B. Townsend, John C. Drach
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Patent number: 8232275Abstract: Compounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purines such as 2-amino-6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6-alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6-cyclopropylaminopurine, 2-amino-6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives with a saturated or unsaturated alkyl group and 6-azapyrimidines.Type: GrantFiled: July 15, 2011Date of Patent: July 31, 2012Assignees: Wayne State University, The Regents of the University of MichiganInventors: Jiri Zemlicka, Shaoman Zhou, John C. Drach
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Patent number: 8202844Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.Type: GrantFiled: March 31, 2011Date of Patent: June 19, 2012Assignee: The Regents of the University of MichiganInventors: Leroy B. Townsend, John C. Drach
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Publication number: 20110275652Abstract: Compounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purines such as 2-amino-6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6-alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6-cyclopropylaminopurine, 2-amino-6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives with a saturated or unsaturated alkyl group and 6-azapyrimidines.Type: ApplicationFiled: July 15, 2011Publication date: November 10, 2011Inventors: Jiri Zemlicka, Shaoman Zhou, John C. Drach
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Publication number: 20110178038Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.Type: ApplicationFiled: March 31, 2011Publication date: July 21, 2011Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Leroy B. Townsend, John C. Drach
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Patent number: 7928080Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.Type: GrantFiled: July 9, 2009Date of Patent: April 19, 2011Assignee: The Regents of the University of MichiganInventors: Leroy B. Townsend, John C. Drach
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Patent number: 7625871Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.Type: GrantFiled: February 28, 2008Date of Patent: December 1, 2009Assignee: The Regents of the University of MichiganInventors: Leroy B. Townsend, John C. Drach
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Publication number: 20090281052Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.Type: ApplicationFiled: July 9, 2009Publication date: November 12, 2009Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Leroy B. Townsend, John C. Drach
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Publication number: 20090118308Abstract: Compounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purines such as 2-amino-6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6-alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6-cyclopropylaminopurine, 2-amino-6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives with a saturated or unsaturated alkyl group and 6-azapyrimidines.Type: ApplicationFiled: June 16, 2008Publication date: May 7, 2009Applicants: Wayne State University, The Regents of the University of MichiganInventors: Jiri Zemlicka, Shaoman Zhou, John C. Drach
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Patent number: 7419963Abstract: The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.Type: GrantFiled: October 6, 2004Date of Patent: September 2, 2008Inventors: Leroy B. Townsend, John C. Drach
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Patent number: 7393855Abstract: Compounds which are active against viruses have the following formulas: wherein B is a purine or pyrimidine heterocyclic ring or base. In a preferred embodiment, the purine include 6-aminopurine (adenine), 6-hydroxypurine (hypoxanthine), 2-amino-6-hydroxypurine (guanine), 2,6-diamino-purine, 2-amino-6-azidopurine, 2-amino-6-halo substituted purines such as 2-amino-6-chloropurine, 2-amino-6-fluoropurine, 2-amino-6-alkoxypurines such as 2-amino-6-methoxypurine, 2-amino-6-cyclopropylaminopurine, 2-amino-6-alkylamino or 2-amino-6-dialkylamino substituted purines, 2-amino-6-thiopurine, 2-amino-6-alkylthio substituted purines, 3-deazapurines, 7-deazapurines and 8-azapurines. The pyrimidine incorporates cytosine, uracil and thymine, 5-halo substituted cytosines and uracils, 5-alkyl substituted cytosines and uracils including derivatives with a saturated or unsaturated alkyl group and 6-azapyrimidines.Type: GrantFiled: September 15, 2004Date of Patent: July 1, 2008Assignees: The Regents of the University of Michigan, Wayne State UniversityInventors: Jiri Zemlicka, Shaoman Zhou, John C. Drach