Abstract: A series of compounds of Formula I which have anti-tumor activity, and are useful in treating viral infections, their compositions and use. ##STR1## In Formula I B is a purine or pyrimidine base; alk.sub.1 alk.sub.2 and alk.sub.3 are chemical bonds or alkylene groups; Q is hydrogen or hydroxyl; and R.sub.1 -R.sub.4 are hydrogen or alkyl.

Abstract: A method is provided for sizing DNA fragments using high speed detection systems, such as flow cytometry to determine unique characteristics of DNA pieces from a sample. In one characterization the DNA piece is fragmented at preselected sites to produce a plurality of DNA fragments. The DNA piece or the resulting DNA fragments are treated with a dye effective to stain stoichiometrically the DNA piece or the DNA fragments. The fluorescence from the dye in the stained fragments is then examined to generate an output functionally related to the number of nucleotides in each one of the DNA fragments. In one embodiment, the intensity of the fluorescence emissions from each fragment is linearly related to the fragment length. The distribution of DNA fragment sizes forms a characterization of the DNA piece for use in forensic and research applications.

Abstract: Method for rapid-base sequencing in DNA and RNA with two-base labeling and employing fluorescent detection of single molecules at two wavelengths. Bases modified to accept fluorescent labels are used to replicate a single DNA or RNA strand to be sequenced. The bases are then sequentially cleaved from the replicated strand, excited with a chosen spectrum of electromagnetic radiation, and the fluorescence from individual, tagged bases detected in the order of cleavage from the strand.

Abstract: Electrically operated hydraulic pump systems are commonly used on tailgate loaders and small dump truck hoists. The systems include a switch which, when closed, couples the vehicle battery to the pump driving motor and a hydraulic lowering valve which, when opened, drains the output port of the pump to a reservoir. The control system for this electric pump system comprises an air cylinder operatively connected to the switch and a second cylinder operatively connected to the hydraulic lowering valve. A switching valve is connected between each air cylinder and a source of air pressure. The switching valves may be operated by an operator to pump or drain hydraulic fluid.

Abstract: The present invention concerns nucleotide analogs and their compositions and use. In particular it relates to novel (phosphonomethoxy) methoxy purine/pyrimidine derivatives.

Abstract: The present invention provides chiral nucleotide analogs having the Formulas I and II ##STR1## and pharmaceutically acceptable salts and solvates thereof, and their pharmaceutical compositions for use in the treatment of viral infections, especially those caused by human immunodeficiency virus (HIV).

Abstract: A hydraulic telescoping ram of the type suitable to tip dump trucks and the like, which permits the use of outer aggressive seals and a bore sealing device by providing a conduit which hydraulically connects the upper end of each cylinder of the telescopic ram with an oil reservoir. This makes it possible to use seals which are not aggressive and which can run on surfaces of somewhat less than top quality, on the internal bottom faces of the rams so as to allow the passage of a small quantity of oil into a gap formed within the ram and cylinder and between the aggressive and non-aggressive seals. The oil which passes the non-aggressive seal is returned to the oil reservoir when the ram is extended.

Abstract: Compounds useful as antiviral agents are defined by the following formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof wherein R.sup.1 is hydrogen or --C(O)R.sup.7 wherein R.sup.7 is hydrogen, alkyl of one to nineteen carbon atoms, hydroxyalkyl of one to eight carbon atoms, alkoxyalkyl of two to nine carbon atoms, alkenyl of two to nineteen carbon atoms, phenyl, 1-adamantyl or 2-carboxyethyl and the pharmaceutically acceptable alkali metal salts thereof;R.sup.2 is --C(O)R.sup.7 wherein R.sup.7 is as defined above;R.sup.3 is hydrogen, halo, thio, lower alkylthio of one to six carbon atoms, azido, NR.sup.9 R.sup.10 wherein R.sup.9 and R.sup.10 are independently hydrogen or lower alkyl of one to six carbon atoms or --NHC(O)R.sup.8 wherein R.sup.8 is hydrogen, alkyl of one to nineteen carbon atoms or 1-adamantyl; and(a) R.sup.6 is hydrogen, halo, lower alkoxy of one to six carbon atoms, azido, thio, lower alkylthio of one to six carbon atoms, --NR.sup.9 R.sup.10 wherein R.sup.9 and R.

Abstract: A low wattage two-four cup displacement water heating apparatus includes a fill basin positioned above a thermostatically controlled electrically heated water reservoir and communicating therewith through a fill tube extending downwardly from the basin to the lower portion of the reservoir. A dome in communication with the reservoir protrudes upwardly therefrom into the basin. A discharge tube having an entry end located in the dome and positioned approximately the bottom level of the basin extends downwardly through the reservoir to an external discharge end. The dome and a venting tube associated with the discharge tube minimize evaporative water loss from the reservoir through the discharge tube.

Abstract: There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV effects.

Abstract: There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially as agents effective against the human immunodeficiency viruses (HIV).

Abstract: The present invention concerns nucleotide analogs and their compositions and use. In particular it relates to novel (phosphonomethoxy) methoxy purine/pyrimidine derivatives.

Abstract: A tailgate closure mechanism for a tailgate hoist serves to move the tailgate from the horizontal position in which it functions as a platform to the upright position in which it functions as a gate. The closure mechanism includes a closing slide which is slidably mounted on at least one of the tailgate support slides and a connecting link that connects the slide to the tailgate. A drive mechanism is provided to drive the closing side toward its raised position. The drive mechanism may be in the form of an hydraulic ram, a compression spring or a combination ram and spring.

Abstract: There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially as agents effective against the human immunodeficiency viruses (HIV).

Abstract: There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV effects.

Abstract: Method and apparatus for removing material from a gas. A mist created by a piezoelectric ultrasonic transducer is contacted with the gas and both gas and mist are passed through baffled separators. Liquid effluent from the separators contains solid material removed from the gas and gaseous material which reacted with the liquid or was absorbed by the liquid. The invention is useful for collecting a sample of material in a gas, such as a vapor in the atmosphere, and in cleaning a gas. A relatively concentrated solution of a material present in a gas in a very small concentration can be obtained.

Abstract: A roll-up door for a container body of a van or the like is provided with a winch which is located in a compartment formed in the header of the door. The winch is connected by flexible winding straps to the upper door panel and the lower door panel so that it is operable to drive the door between the open and closed position. The door panels are hingedly connected by hinges in which the hinge pin is located at the inner face of the door. Flexible sealing members are connected to each jamb and bear against a marginal edge portion of the outer face of the door when the door is in the closed position. A control system for controlling the direction of rotation of the reversible D.C. motor is provided which includes a master control circuit and a slave control circuit which is selectively operable.

Abstract: There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV effects.

Abstract: A method is provided for the rapid base sequencing of DNA or RNA fragments wherein a single fragment of DNA or RNA is provided with identifiable bases and suspended in a moving flow stream. An exonuclease sequentially cleaves individual bases from the end of the suspended fragment. The moving flow stream maintains the cleaved bases in an orderly train for subsequent detection and identification. In a particular embodiment, individual bases forming the DNA or RNA fragments are individually tagged with a characteristic fluorescent dye. The train of bases is then excited to fluorescence with an output spectrum characteristic of the individual bases. Accordingly, the base sequence of the original DNA or RNA fragment can be reconstructed.