Abstract: An embodiment of the system for publishing events of a telephony application to a client includes a call router that generates events from the telephony application and an event router that manages the publication of events generated by the call router and that manages the subscription to events by clients.

Abstract: A method and system for real-time eventing including interacting with at least one configuration attribute according to instructions specified through an application programming interface (API); adding subscribers for an event channel; generating an event from operation of an application; publishing the event message to the event channel on an event router; processing the event message according to the at least one configuration attribute; identifying a subscriber to the event channel; and sending the event from the event router to the subscriber.

Abstract: A method for processing telephony sessions of a network including at least one application server and a call router, the method including the steps of assigning a primary Uniform Resource Identifier (URI) and at least a secondary URI to an application; mapping a telephony session to the primary URI; communicating with the application server designated by the primary URI using an application layer protocol; receiving telephony instructions from the application server and processing the telephony instructions with the call router; detecting an application event; and upon detecting the application event, communicating with the application server designated by the secondary URI.

Abstract: The disclosed apparatus may include a first rigid lens; a second rigid lens, a seal that couples the first rigid lens and the second rigid lens together, where the first rigid lens, the second rigid lens, and the seal define a cavity; and a fluid within the cavity, where the seal is adapted to admit expansions of the fluid within the cavity. Various other apparatuses and methods also disclosed.

Abstract: Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use.

Abstract: A varifocal lens includes a substrate having an inclined region, a primary electrode disposed over the inclined region of the substrate, a dielectric layer disposed over the primary electrode, a deformable membrane disposed over and at least partially spaced away from the dielectric layer, a secondary electrode disposed over a surface of the deformable membrane facing toward or away from the dielectric layer and overlying at least a portion of the primary electrode, and a fluid between the membrane and the substrate, wherein a surface of the dielectric layer facing the secondary electrode comprises a textured surface.

Abstract: An optical element can be adjusted using a displacement element in an actuator assembly. The actuator assembly includes a plurality of lead screws and a mechanical linkage configured to simultaneously rotate the lead screws. The actuator assembly further includes a displacement element configured to act upon the optical element, through translational motion of the displacement element in response to rotation of the lead screws. Multiple optical elements can be adjusted simultaneously using respective displacement elements. In some embodiments, a controller determines a target position for at least one displacement element, where the target position is configured to provide a desired optical characteristic such as an optical power. The controller can apply power to the actuator to move the at least one displacement element. The controller can also shut off power upon detecting that the at least one displacement element has reached the target position or an end-of-travel position.

Abstract: An apparatus having an asymmetric adjustable lens with a deformable optical element. The apparatus may also include one or more actuators coupled to a deformable element of the asymmetric adjustable lens in a direct-drive configuration such that (1) mechanical action of the one or more actuators applies force to the deformable optical element and (2) the force applied by the mechanical action of the one or more actuators changes an optical property of the asymmetric adjustable lens by deforming the deformable optical element. Various other devices, systems, and methods are also disclosed.

Abstract: The disclosed optical lens assemblies may include a deformable element, a structural support element, a substantially transparent deformable medium positioned between the deformable element and the structural support element, a compliant peripheral component positioned between peripheral portions of the deformable element and the structural support element, and an actuator configured to displace at least a portion of the compliant peripheral component to deform the deformable element and change at least one optical property of the optical lens assembly. Related head-mounted displays and methods of fabricating such optical lens assemblies are also disclosed.

Abstract: A system described herein may provide for the use of artificial intelligence/machine learning (“AI/ML”) techniques to generate models for various locations or regions (e.g., sectors) associated with one or more radio access networks (“RANs”) of a wireless network. The system may further use AI/ML techniques to generate interference models to reflect types and/or amounts of radio frequency (“RF”) interference measured within the RAN. The system may further determine, based on received RF metrics for a given sector, a particular interference model associated with the sector. Based on a sector model associated with the sector and the determined interference model, one or more actions may be determined in order to remediate any potential interference associated with the sector or surrounding sectors.

Abstract: The disclosed optical lens assemblies may include a deformable optical element and at least one adaptive element positioned at a peripheral region of the deformable optical element. The deformable optical element may include a substantially transparent electroactive element positioned at least partially within an optical aperture of the deformable optical element. An electrical driving circuit may be configured to apply a voltage to the electroactive element to deform the electroactive element and thus change at least one optical property of the deformable optical element. The at least one adaptive element may be positioned outside of the optical aperture and may be configured to alter a physical boundary condition of the deformable optical element. Various other methods and systems are also disclosed.

Abstract: A casting method involves providing a precursor to a mold that includes a deformable surface overlying a chamber, shaping the deformable surface according to a surface profile by adjusting a fluid pressure within the chamber and driving one or more actuators that are configured to distort the deformable surface, and solidifying the precursor while the deformable surface is shaped according to the surface profile to form an optical element.

Abstract: The present invention relates to novel Amido-Substituted Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, and R4 are as defined herein. The present invention also relates to compositions comprising at least one Amido-Substituted Heterocycle Compound, and methods of using the Amido-Substituted Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: A method is disclosed of secure data transmission comprising sending a data request from a client device to a server device, the data request comprising a first share of a first encryption key, and a first location in the database at which is located desired double-encrypted data; receiving the sent data request at the server device; extracting, at the server device, the first share and the first location from the received data request; obtaining, at the server device, the desired double-encrypted data from the database using the extracted first location; generating, at the server device, the first encryption key using the extracted first share and one or more additional shares of the first encryption key held by the server device; and decrypting, at the server device, the obtained desired double-encrypted data using the generated first encryption key to form single-encrypted data.

Abstract: The present invention relates to novel Indazole Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5 and R6 are as defined herein. The present invention also relates to compositions comprising at least one Indazole Derivative, and methods of using the Indazole Derivatives for treating or preventing a herpesvirus infection in a patient.

Abstract: The present invention relates to novel Bicyclic Heterocycle Compounds of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, X, Y, Z, R1 R5, R6, and R7 are as defined herein. The present invention also relates to compositions comprising at least one Bicyclic Heterocycle Compound, and methods of using the Bicyclic Heterocycle Compounds for treating or preventing a herpesvirus infection in a patient.

Abstract: Eyeglass devices may include a frame shaped and sized to be worn by a user at least partially in front of the user's eyes, a varifocal optical element mounted to the frame, and an eye-tracking element mounted to the frame. The varifocal optical element may include a substantially transparent actuator positioned at least partially within an optical aperture of the varifocal optical element and configured to alter a shape of the varifocal optical element upon actuation. The eye-tracking element may be configured to track at least a gaze direction of the user's eyes, and the varifocal optical element may be configured to change, based on information from the eye-tracking element, in at least one optical property including a focal distance. Various other devices, systems, and methods are also disclosed.

Abstract: In some examples, a device includes a fluid lens having a substrate and a membrane connected to the substrate using a flexure. The fluid lens may include a fluid located within a cavity at least partially defined by the substrate and the membrane. The flexure may include a membrane attachment and an elastic element. The device may be configured so that a displacement of the membrane attachment adjusts a profile of the membrane, and may induce a compression of at least a portion of the elastic member. In some examples, a flexure may include a plurality of elastic elements, which may be attached to the substrate (e.g., through a flexure support), and a rigid element, that may include or be connected to the membrane attachment. Example devices include head-mounted devices, such as augmented reality or virtual reality devices.

Abstract: A system described herein may provide for the use of artificial intelligence/machine learning (“AI/ML”) techniques to generate models for various locations or regions (e.g., sectors) associated with one or more radio access networks (“RANs”) of a wireless network. The system may further use AI/ML techniques to generate interference models to reflect types and/or amounts of radio frequency (“RF”) interference measured within the RAN. The system may further determine, based on received RF metrics for a given sector, a particular interference model associated with the sector. Based on a sector model associated with the sector and the determined interference model, one or more actions may be determined in order to remediate any potential interference associated with the sector or surrounding sectors.

Abstract: The print head cover (83) of an electrostatic deflection inkjet printer is made of a material having an electrical surface resistivity of no more than 1012 ohms per square or an electrical volume resistivity of no more than 109 ohm metres and is electrically connected to an earth line (93, 97). This prevents build-up of electric charge on the cover (83). The resistance from the surface of the cover (83) to a place where a cover earth line (93) joins a signal earth line (97) or enters the umbilical (7) is at least 16000 times the resistance from that place to earth. This prevents an electrostatic discharge to the cover (83) disrupting the electronic circuits. The high resistance earth connection for the cover (83) avoids the need for an earthing wire braid in the umbilical (7). The cover (83) may be moulded from an antistatic or static dissipative material.