Abstract: Eyeglass devices may include a frame shaped and sized to be worn by a user at least partially in front of the user's eyes and a varifocal optical element mounted to the frame. The varifocal optical element may include an actuator configured to alter a shape of the varifocal optical element upon actuation. The varifocal optical element may be configured to change, based on information from the eye-tracking element, in at least one optical property including a focal distance.

Abstract: A variable-stiffness spring member may be integrated into a deformable optical element, such as a fluid lens. An example fluid lens may include a substrate, an actuator, a fluid layer disposed between the substrate and the actuator, and a spring member disposed between the substrate and the actuator. The spring member may include a flexure that at least partially surrounds the fluid layer and a spring stiffness of the flexure may differ at each of at least two peripheral locations around the fluid layer. Various other devices, systems, and methods are also disclosed.

Abstract: Eyeglass devices may include a frame shaped and sized to be worn by a user at least partially in front of the user's eyes, a varifocal optical element mounted to the frame, and an eye-tracking element mounted to the frame. The varifocal optical element may include a substantially transparent actuator positioned at least partially within an optical aperture of the varifocal optical element and configured to alter a shape of the varifocal optical element upon actuation. The eye-tracking element may be configured to track at least a gaze direction of the user's eyes, and the varifocal optical element may be configured to change, based on information from the eye-tracking element, in at least one optical property including a focal distance. Various other devices, systems, and methods are also disclosed.

Abstract: Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use.

Abstract: Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use.

Abstract: We describe an improved conductive biocompatible scaffold for electroporation. The biocompatible scaffold comprises biocompatible material (e.g., collagen and/or other extracellular matrix) and incorporates a metal or polymer network or dispersion that conducts an electrical current through the scaffold. The material can adsorb or trap or bind nucleic acids (e.g., RNA or DNA), nanoparticles, proteins and/or small molecules; subsequently cells are placed in proximity to or in contact with the scaffold and an electrical current passed through the scaffold, thereby facilitating cellular entry of the nucleic acids, nanoparticles, proteins and/or small molecules, particularly into those cells that are in proximity of the scaffold.

Abstract: The disclosed optical lens assemblies may include a deformable optical element including a substantially transparent transducer configured to deform, and thus change at least one optical property of, the deformable optical element. At least a portion of the substantially transparent transducer may be positioned within a substantially transparent optical aperture of the optical lens assembly. Various head-mounted displays incorporating such an optical lens assembly, and methods of fabricating the same, are also disclosed.

Abstract: The disclosed apparatus may include a first rigid lens; a second rigid lens, a seal that couples the first rigid lens and the second rigid lens together, where the first rigid lens, the second rigid lens, and the seal define a cavity; and a fluid within the cavity, where the seal is adapted to admit expansions of the fluid within the cavity. Various other apparatuses and methods also disclosed.

Abstract: Compounds and compositions for the transient expression of exogenous telomerase activity in a cell are provided. The compounds and compositions, which relate to a ribonucleic acid coding for a telomerase reverse transcriptase, are useful in the extension of telomeres in cells needing such treatment. Such cells include, for example, cells that contain shortened telomeres and cells from subjects that may benefit from telomere extension, for example subjects that suffer from, or are at risk of suffering from, age-related or other illnesses. Also provided are methods of extending telomeres through the administration of the provided compounds and compositions to animal cells, either in vitro or in vivo, and kits including the compounds or compositions and instructions for use.

Abstract: A varifocal lens includes a substrate having an inclined region, a primary electrode disposed over the inclined region of the substrate, a dielectric layer disposed over the primary electrode, a deformable membrane disposed over and at least partially spaced away from the dielectric layer, a secondary electrode disposed over a surface of the deformable membrane facing toward or away from the dielectric layer and overlying at least a portion of the primary electrode, and a fluid between the membrane and the substrate, wherein a surface of the dielectric layer facing the secondary electrode comprises a textured surface.

Abstract: An optical element can be adjusted using a displacement element in an actuator assembly. The actuator assembly includes a plurality of lead screws and a mechanical linkage configured to simultaneously rotate the lead screws. The actuator assembly further includes a displacement element configured to act upon the optical element, through translational motion of the displacement element in response to rotation of the lead screws. Multiple optical elements can be adjusted simultaneously using respective displacement elements. In some embodiments, a controller determines a target position for at least one displacement element, where the target position is configured to provide a desired optical characteristic such as an optical power. The controller can apply power to the actuator to move the at least one displacement element. The controller can also shut off power upon detecting that the at least one displacement element has reached the target position or an end-of-travel position.

Abstract: An apparatus having an asymmetric adjustable lens with a deformable optical element. The apparatus may also include one or more actuators coupled to a deformable element of the asymmetric adjustable lens in a direct-drive configuration such that (1) mechanical action of the one or more actuators applies force to the deformable optical element and (2) the force applied by the mechanical action of the one or more actuators changes an optical property of the asymmetric adjustable lens by deforming the deformable optical element. Various other devices, systems, and methods are also disclosed.

Abstract: The disclosed optical lens assemblies may include a deformable element, a structural support element, a substantially transparent deformable medium positioned between the deformable element and the structural support element, a compliant peripheral component positioned between peripheral portions of the deformable element and the structural support element, and an actuator configured to displace at least a portion of the compliant peripheral component to deform the deformable element and change at least one optical property of the optical lens assembly. Related head-mounted displays and methods of fabricating such optical lens assemblies are also disclosed.

Abstract: A system described herein may provide for the use of artificial intelligence/machine learning (“AI/ML”) techniques to generate models for various locations or regions (e.g., sectors) associated with one or more radio access networks (“RANs”) of a wireless network. The system may further use AI/ML techniques to generate interference models to reflect types and/or amounts of radio frequency (“RF”) interference measured within the RAN. The system may further determine, based on received RF metrics for a given sector, a particular interference model associated with the sector. Based on a sector model associated with the sector and the determined interference model, one or more actions may be determined in order to remediate any potential interference associated with the sector or surrounding sectors.

Abstract: A casting method involves providing a precursor to a mold that includes a deformable surface overlying a chamber, shaping the deformable surface according to a surface profile by adjusting a fluid pressure within the chamber and driving one or more actuators that are configured to distort the deformable surface, and solidifying the precursor while the deformable surface is shaped according to the surface profile to form an optical element.

Abstract: The disclosed optical lens assemblies may include a deformable optical element and at least one adaptive element positioned at a peripheral region of the deformable optical element. The deformable optical element may include a substantially transparent electroactive element positioned at least partially within an optical aperture of the deformable optical element. An electrical driving circuit may be configured to apply a voltage to the electroactive element to deform the electroactive element and thus change at least one optical property of the deformable optical element. The at least one adaptive element may be positioned outside of the optical aperture and may be configured to alter a physical boundary condition of the deformable optical element. Various other methods and systems are also disclosed.

Abstract: Eyeglass devices may include a frame shaped and sized to be worn by a user at least partially in front of the user's eyes, a varifocal optical element mounted to the frame, and an eye-tracking element mounted to the frame. The varifocal optical element may include a substantially transparent actuator positioned at least partially within an optical aperture of the varifocal optical element and configured to alter a shape of the varifocal optical element upon actuation. The eye-tracking element may be configured to track at least a gaze direction of the user's eyes, and the varifocal optical element may be configured to change, based on information from the eye-tracking element, in at least one optical property including a focal distance. Various other devices, systems, and methods are also disclosed.

Abstract: In some examples, a device includes a fluid lens having a substrate and a membrane connected to the substrate using a flexure. The fluid lens may include a fluid located within a cavity at least partially defined by the substrate and the membrane. The flexure may include a membrane attachment and an elastic element. The device may be configured so that a displacement of the membrane attachment adjusts a profile of the membrane, and may induce a compression of at least a portion of the elastic member. In some examples, a flexure may include a plurality of elastic elements, which may be attached to the substrate (e.g., through a flexure support), and a rigid element, that may include or be connected to the membrane attachment. Example devices include head-mounted devices, such as augmented reality or virtual reality devices.

Abstract: A system described herein may provide for the use of artificial intelligence/machine learning (“AI/ML”) techniques to generate models for various locations or regions (e.g., sectors) associated with one or more radio access networks (“RANs”) of a wireless network. The system may further use AI/ML techniques to generate interference models to reflect types and/or amounts of radio frequency (“RF”) interference measured within the RAN. The system may further determine, based on received RF metrics for a given sector, a particular interference model associated with the sector. Based on a sector model associated with the sector and the determined interference model, one or more actions may be determined in order to remediate any potential interference associated with the sector or surrounding sectors.

Abstract: A system described herein may provide for the use of artificial intelligence/machine learning (“AI/MIL”) techniques to generate models for various locations or regions (e.g., sectors) associated with one or more radio access networks (“RANs”) of a wireless network. The system may further use AI/ML techniques to generate interference models to reflect types and/or amounts of radio frequency (“RF”) interference measured within the RAN. The system may further determine, based on received RF metrics for a given sector, a particular interference model associated with the sector. Based on a sector model associated with the sector and the determined interference model, one or more actions may be determined in order to remediate any potential interference associated with the sector or surrounding sectors.