Patents by Inventor John Crosby
John Crosby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240065931Abstract: A system and method of using a lead introduced to a subject proximate to a region of pain is contemplated to deliver pain relief without the need for multiple needle insertions or electrical stimulation. The three-dimensional lead may include spring-like characteristics and/or coils to translate mechanical energy into the therapy.Type: ApplicationFiled: November 6, 2023Publication date: February 29, 2024Inventors: Meredith McGee, Nathan Crosby, John Chae, Joseph W. Boggs
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Patent number: 10399143Abstract: A method includes forming a mold, the mold having at least one mold portion defining the shape of an element to be removed from the component in a subsequent manufacturing step and having a reduced cross-sectional area. The at least one mold portion includes at least one recess which further reduces the cross sectional area of the cavity and increases the surface area of the at least one mold portion or the at least one mold portion includes a plurality of projections which increase the surface area of the least one mold portion thereby increasing radiative heat loss from the at least one mold portion during the process. A mold for use in this method and a turbine blade formed using this method, are also provided.Type: GrantFiled: June 3, 2015Date of Patent: September 3, 2019Assignee: ROLLS-ROYCE plcInventors: John Harold Boswell, Terence Ivan Simpson, Phillip John Crosby
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Patent number: 10247836Abstract: An embodiment of a method for restoring detector resolution in an X-Ray fluorescence instrument is described that comprises: measuring a resolution value of a detector in the X-Ray fluorescence instrument using a standard material at a first temperature; determining that the measured resolution value deviates from a target value; and adjusting the temperature of the detector to a second temperature that restores the resolution value of the detector to the target value, wherein the temperature is adjusted by an amount defined by a relationship of temperature change to the degree of deviation of detector resolution from the target value.Type: GrantFiled: December 15, 2015Date of Patent: April 2, 2019Assignee: THERMO GAMMA-METRICS PTY LTDInventor: Bryan John Crosby
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Patent number: 10012604Abstract: An apparatus includes at least one X-ray source that emits X-rays toward a sample, an X-ray fluorescence (XRF) detector that detects X-ray radiation scattered from the sample, an internal standard that emits scattered X-ray radiation in response to X-rays emitted from the at least one X-ray source, and a carriage assembly that translates the at least one X-ray source and XRF detector between a sample measurement position and an internal standard measurement position.Type: GrantFiled: December 15, 2015Date of Patent: July 3, 2018Assignee: THERMO GAMMA-METRICS PTY LTDInventors: Bryan John Crosby, Simon Liemar, Peter William Hayles, Charlie Minghua Mao, Tejas Indravadanbhai Shah, Hao Zeng
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Patent number: 9976972Abstract: A thermal control apparatus adapted for use with a pressurized air supply for controlling temperature of a component includes a vortex tube having an inlet adapted for connection with the pressurized air supply, a cold air outlet, and a hot air outlet, and a heat exchanger in fluid communication with the cold air outlet of the vortex tube, the heat exchanger being in thermal contact with the component and thereby controlling the temperature of the component. The heat exchanger further includes a post-heat-exchange exhaust air outlet in fluid communication with an exhaust air inlet adapted to direct the exhaust air along an outside of the vortex tube.Type: GrantFiled: December 15, 2015Date of Patent: May 22, 2018Assignee: THERMO GAMMA-METRICS PTY LTDInventors: Bryan John Crosby, Simon Liemar
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Publication number: 20170167990Abstract: An apparatus includes at least one X-ray source that emits X-rays toward a sample, an X-ray fluorescence (XRF) detector that detects X-ray radiation scattered from the sample, an internal standard that emits scattered X-ray radiation in response to X-rays emitted from the at least one X-ray source, and a carriage assembly that translates the at least one X-ray source and XRF detector between a sample measurement position and an internal standard measurement position.Type: ApplicationFiled: December 15, 2015Publication date: June 15, 2017Inventors: Bryan John CROSBY, Simon LIEMAR, Peter William HAYLES, Charlie Minghua MAO, Tejas Indravadanbhai SHAH, Hao ZENG
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Publication number: 20170167989Abstract: A thermal control apparatus adapted for use with a pressurized air supply for controlling temperature of a component includes a vortex tube having an inlet adapted for connection with the pressurized air supply, a cold air outlet, and a hot air outlet, and a heat exchanger in fluid communication with the cold air outlet of the vortex tube, the heat exchanger being in thermal contact with the component and thereby controlling the temperature of the component. The heat exchanger further includes a post-heat-exchange exhaust air outlet in fluid communication with an exhaust air inlet adapted to direct the exhaust air along an outside of the vortex tube.Type: ApplicationFiled: December 15, 2015Publication date: June 15, 2017Inventors: Bryan John CROSBY, Simon LIEMAR
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Publication number: 20170168172Abstract: An embodiment of a method for restoring detector resolution in an X-Ray fluorescence instrument is described that comprises: measuring a resolution value of a detector in the X-Ray fluorescence instrument using a standard material at a first temperature; determining that the measured resolution value deviates from a target value; and adjusting the temperature of the detector to a second temperature that restores the resolution value of the detector to the target value, wherein the temperature is adjusted by an amount defined by a relationship of temperature change to the degree of deviation of detector resolution from the target value.Type: ApplicationFiled: December 15, 2015Publication date: June 15, 2017Inventor: Bryan John CROSBY
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Publication number: 20160001360Abstract: A method includes forming a mould, the mould having at least one mould portion defining the shape of an element to be removed from the component in a subsequent manufacturing step and having a reduced cross-sectional area. The at least one mould portion includes at least one recess which further reduces the cross sectional area of the cavity and increases the surface area of the at least one mould portion or the at least one mould portion includes a plurality of projections which increase the surface area of the least one mould portion thereby increasing radiative heat loss from said at least one mould portion during said process.Type: ApplicationFiled: June 3, 2015Publication date: January 7, 2016Inventors: John Harold BOSWELL, Terence Ivan SIMPSON, Phillip John CROSBY
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Patent number: 8914256Abstract: In one embodiment, a technique is provided for exchanging a design of a structure between a modeling application and an analysis application. The model of the structure is scanned in the modeling application, to identify model elements and their interrelationships. Using the identified model elements and their interrelationships, an analytical interface model is generated within the modeling application that provides an abstracted representation of the structure. Such analytical interface model is viewable and modifiable within the user interface of the modeling application. Information regarding the analytical interface model is transferred to the analysis application. This information is used by the analysis application to create a separate analytical model maintained and used by the analysis application.Type: GrantFiled: January 21, 2009Date of Patent: December 16, 2014Assignee: Bentley Systems, IncorporatedInventors: Matthias Schneider, John A. Crosby
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Patent number: 8754240Abstract: The present invention relates to a chemical process for the manufacture of a compound of Formula IIType: GrantFiled: November 17, 2010Date of Patent: June 17, 2014Assignee: AstraZeneca ABInventors: Euan Alexander Arnott, John Crosby, Mathew Charles Evans, James Gair Ford, Martin Francis Jones, Kevin William Leslie, Ian Michael McFarlane, George Joseph Sependa
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Publication number: 20110257395Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline.Type: ApplicationFiled: November 17, 2010Publication date: October 20, 2011Applicant: AstraZeneca ABInventors: Euan Alexander Arnott, John Crosby, Matthew Charles Evans, James Gair Ford, Martin Francis Jones, Kevin William Leslie, Ian Michael McFarlane, George Joseph Sependa
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Patent number: 7851623Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-[(4-fluoro-2-methy-1-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline starting from a compound of Formula IX: wherein R4 is a protecting group; or an intermediate there between, using process steps, reagents and conditions as described.Type: GrantFiled: October 31, 2007Date of Patent: December 14, 2010Assignee: AstraZeneca ABInventors: Euan Alexander Arnott, John Crosby, Matthew Charles Evans, James Gair Ford, Martin Francis Jones, Kevin William Leslie, Ian Michael McFarlane, George Joseph Sependa
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Publication number: 20080221322Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline.Type: ApplicationFiled: October 31, 2007Publication date: September 11, 2008Applicant: AstraZeneca ABInventors: Euan Alexander Arnott, John Crosby, Mathew Charles Evans, James Gair Ford, Martin Francis Jones, Kevin William Leslie, Ian Michael McFarlane, George Joseph Sependa
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Patent number: 6362376Abstract: 2-Benzyloxyalkyl halophenones of the formula (3): wherein X1 and X2 are each independently H, Cl or F, provided that at least one of X1 and X2 is Cl or F; one of R3 and R4 is H and the other is optionally substituted benzyloxy; and R5 is an unsubstituted alkyl, preferably a C1-6 alkyl group. The compounds are useful as intermediates for preparing 2-hydroxyalkyl halophenones.Type: GrantFiled: August 8, 2001Date of Patent: March 26, 2002Assignee: Avecia LimitedInventors: John Crosby, Kevin Douglas Bailey, Michael John Monteith
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Patent number: 6300522Abstract: A process is provided for the preparation of compounds of Formula (1): wherein X1 and X2 are each independently H, Cl or F, provided that at least one of X1 and X2 is Cl or F; one of R1 and R2 is H and the other is OH; and R5 is an unsubstituted alkyl, preferably a C1-6 alkyl, group.Type: GrantFiled: November 29, 2000Date of Patent: October 9, 2001Assignee: Avecia LimitedInventors: John Crosby, Kevin Douglas Bailey, Michael John Monteith
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Patent number: 6261830Abstract: An enzymatic process for preparing amides of Formula I wherein X, E and * have the meanings defined in the specification. Chiral intermediates useful for preparing compound of Formula I and enzymatic processes for preparing such chiral intermediates are also described.Type: GrantFiled: May 31, 2000Date of Patent: July 17, 2001Assignee: Zeneca LTDInventors: John Crosby, John David Pittam, Robert Antony Holt
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Patent number: 6110729Abstract: A stereoselective method for making compounds of Formula VIII ##STR1## wherein A and * are as defined in the specification. Enzymic processes and intermediates useful for preparing compound of Formula VIII are disclosed.Type: GrantFiled: October 9, 1998Date of Patent: August 29, 2000Assignee: Zeneca LimitedInventors: John Crosby, John David Pittam, Robert Antony Holt
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Patent number: 5989509Abstract: A process for purifying elemental phosphorus that contains antimony using an oxidizer, such as hydrogen peroxide, peroxymonosulfate, peroxydisulfate, or a hypochlorite, in a two phase system containing water and phosphorus as the two liquids. A purified elemental phosphorus having 200 ppb or less antimony content.Type: GrantFiled: June 9, 1997Date of Patent: November 23, 1999Assignee: EMC CorporationInventors: Louis T. Gunkel, John Crosby, Theodore F. Munday, Paul J. Beck
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Patent number: 5670662Abstract: A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centres which comprises selective reaction of at least one isomer with a reagent catalysed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of Formula (1): ##STR1## wherein: Z is --H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; andY is formyl or protected formyl.Type: GrantFiled: March 28, 1996Date of Patent: September 23, 1997Assignee: Zeneca LimitedInventors: John Crosby, Andrew Blacker, John Albert Leslie Herbert