Patents by Inventor John Crosby

John Crosby has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240065931
    Abstract: A system and method of using a lead introduced to a subject proximate to a region of pain is contemplated to deliver pain relief without the need for multiple needle insertions or electrical stimulation. The three-dimensional lead may include spring-like characteristics and/or coils to translate mechanical energy into the therapy.
    Type: Application
    Filed: November 6, 2023
    Publication date: February 29, 2024
    Inventors: Meredith McGee, Nathan Crosby, John Chae, Joseph W. Boggs
  • Patent number: 10399143
    Abstract: A method includes forming a mold, the mold having at least one mold portion defining the shape of an element to be removed from the component in a subsequent manufacturing step and having a reduced cross-sectional area. The at least one mold portion includes at least one recess which further reduces the cross sectional area of the cavity and increases the surface area of the at least one mold portion or the at least one mold portion includes a plurality of projections which increase the surface area of the least one mold portion thereby increasing radiative heat loss from the at least one mold portion during the process. A mold for use in this method and a turbine blade formed using this method, are also provided.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: September 3, 2019
    Assignee: ROLLS-ROYCE plc
    Inventors: John Harold Boswell, Terence Ivan Simpson, Phillip John Crosby
  • Patent number: 10247836
    Abstract: An embodiment of a method for restoring detector resolution in an X-Ray fluorescence instrument is described that comprises: measuring a resolution value of a detector in the X-Ray fluorescence instrument using a standard material at a first temperature; determining that the measured resolution value deviates from a target value; and adjusting the temperature of the detector to a second temperature that restores the resolution value of the detector to the target value, wherein the temperature is adjusted by an amount defined by a relationship of temperature change to the degree of deviation of detector resolution from the target value.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: April 2, 2019
    Assignee: THERMO GAMMA-METRICS PTY LTD
    Inventor: Bryan John Crosby
  • Patent number: 10012604
    Abstract: An apparatus includes at least one X-ray source that emits X-rays toward a sample, an X-ray fluorescence (XRF) detector that detects X-ray radiation scattered from the sample, an internal standard that emits scattered X-ray radiation in response to X-rays emitted from the at least one X-ray source, and a carriage assembly that translates the at least one X-ray source and XRF detector between a sample measurement position and an internal standard measurement position.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: July 3, 2018
    Assignee: THERMO GAMMA-METRICS PTY LTD
    Inventors: Bryan John Crosby, Simon Liemar, Peter William Hayles, Charlie Minghua Mao, Tejas Indravadanbhai Shah, Hao Zeng
  • Patent number: 9976972
    Abstract: A thermal control apparatus adapted for use with a pressurized air supply for controlling temperature of a component includes a vortex tube having an inlet adapted for connection with the pressurized air supply, a cold air outlet, and a hot air outlet, and a heat exchanger in fluid communication with the cold air outlet of the vortex tube, the heat exchanger being in thermal contact with the component and thereby controlling the temperature of the component. The heat exchanger further includes a post-heat-exchange exhaust air outlet in fluid communication with an exhaust air inlet adapted to direct the exhaust air along an outside of the vortex tube.
    Type: Grant
    Filed: December 15, 2015
    Date of Patent: May 22, 2018
    Assignee: THERMO GAMMA-METRICS PTY LTD
    Inventors: Bryan John Crosby, Simon Liemar
  • Publication number: 20170167990
    Abstract: An apparatus includes at least one X-ray source that emits X-rays toward a sample, an X-ray fluorescence (XRF) detector that detects X-ray radiation scattered from the sample, an internal standard that emits scattered X-ray radiation in response to X-rays emitted from the at least one X-ray source, and a carriage assembly that translates the at least one X-ray source and XRF detector between a sample measurement position and an internal standard measurement position.
    Type: Application
    Filed: December 15, 2015
    Publication date: June 15, 2017
    Inventors: Bryan John CROSBY, Simon LIEMAR, Peter William HAYLES, Charlie Minghua MAO, Tejas Indravadanbhai SHAH, Hao ZENG
  • Publication number: 20170167989
    Abstract: A thermal control apparatus adapted for use with a pressurized air supply for controlling temperature of a component includes a vortex tube having an inlet adapted for connection with the pressurized air supply, a cold air outlet, and a hot air outlet, and a heat exchanger in fluid communication with the cold air outlet of the vortex tube, the heat exchanger being in thermal contact with the component and thereby controlling the temperature of the component. The heat exchanger further includes a post-heat-exchange exhaust air outlet in fluid communication with an exhaust air inlet adapted to direct the exhaust air along an outside of the vortex tube.
    Type: Application
    Filed: December 15, 2015
    Publication date: June 15, 2017
    Inventors: Bryan John CROSBY, Simon LIEMAR
  • Publication number: 20170168172
    Abstract: An embodiment of a method for restoring detector resolution in an X-Ray fluorescence instrument is described that comprises: measuring a resolution value of a detector in the X-Ray fluorescence instrument using a standard material at a first temperature; determining that the measured resolution value deviates from a target value; and adjusting the temperature of the detector to a second temperature that restores the resolution value of the detector to the target value, wherein the temperature is adjusted by an amount defined by a relationship of temperature change to the degree of deviation of detector resolution from the target value.
    Type: Application
    Filed: December 15, 2015
    Publication date: June 15, 2017
    Inventor: Bryan John CROSBY
  • Publication number: 20160001360
    Abstract: A method includes forming a mould, the mould having at least one mould portion defining the shape of an element to be removed from the component in a subsequent manufacturing step and having a reduced cross-sectional area. The at least one mould portion includes at least one recess which further reduces the cross sectional area of the cavity and increases the surface area of the at least one mould portion or the at least one mould portion includes a plurality of projections which increase the surface area of the least one mould portion thereby increasing radiative heat loss from said at least one mould portion during said process.
    Type: Application
    Filed: June 3, 2015
    Publication date: January 7, 2016
    Inventors: John Harold BOSWELL, Terence Ivan SIMPSON, Phillip John CROSBY
  • Patent number: 8914256
    Abstract: In one embodiment, a technique is provided for exchanging a design of a structure between a modeling application and an analysis application. The model of the structure is scanned in the modeling application, to identify model elements and their interrelationships. Using the identified model elements and their interrelationships, an analytical interface model is generated within the modeling application that provides an abstracted representation of the structure. Such analytical interface model is viewable and modifiable within the user interface of the modeling application. Information regarding the analytical interface model is transferred to the analysis application. This information is used by the analysis application to create a separate analytical model maintained and used by the analysis application.
    Type: Grant
    Filed: January 21, 2009
    Date of Patent: December 16, 2014
    Assignee: Bentley Systems, Incorporated
    Inventors: Matthias Schneider, John A. Crosby
  • Patent number: 8754240
    Abstract: The present invention relates to a chemical process for the manufacture of a compound of Formula II
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: June 17, 2014
    Assignee: AstraZeneca AB
    Inventors: Euan Alexander Arnott, John Crosby, Mathew Charles Evans, James Gair Ford, Martin Francis Jones, Kevin William Leslie, Ian Michael McFarlane, George Joseph Sependa
  • Publication number: 20110257395
    Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline.
    Type: Application
    Filed: November 17, 2010
    Publication date: October 20, 2011
    Applicant: AstraZeneca AB
    Inventors: Euan Alexander Arnott, John Crosby, Matthew Charles Evans, James Gair Ford, Martin Francis Jones, Kevin William Leslie, Ian Michael McFarlane, George Joseph Sependa
  • Patent number: 7851623
    Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-[(4-fluoro-2-methy-1-1H-indol-5-yl)oxy]-6-methoxy-7-[3-(pyrrolidin-1-yl)propoxy]quinazoline starting from a compound of Formula IX: wherein R4 is a protecting group; or an intermediate there between, using process steps, reagents and conditions as described.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: December 14, 2010
    Assignee: AstraZeneca AB
    Inventors: Euan Alexander Arnott, John Crosby, Matthew Charles Evans, James Gair Ford, Martin Francis Jones, Kevin William Leslie, Ian Michael McFarlane, George Joseph Sependa
  • Publication number: 20080221322
    Abstract: The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilising said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-fluoro-2-methylindol-5-yloxy)-6-methoxy-7-(3-pyrrolidin-1-ylpropoxy)quinazoline.
    Type: Application
    Filed: October 31, 2007
    Publication date: September 11, 2008
    Applicant: AstraZeneca AB
    Inventors: Euan Alexander Arnott, John Crosby, Mathew Charles Evans, James Gair Ford, Martin Francis Jones, Kevin William Leslie, Ian Michael McFarlane, George Joseph Sependa
  • Patent number: 6362376
    Abstract: 2-Benzyloxyalkyl halophenones of the formula (3): wherein X1 and X2 are each independently H, Cl or F, provided that at least one of X1 and X2 is Cl or F; one of R3 and R4 is H and the other is optionally substituted benzyloxy; and R5 is an unsubstituted alkyl, preferably a C1-6 alkyl group. The compounds are useful as intermediates for preparing 2-hydroxyalkyl halophenones.
    Type: Grant
    Filed: August 8, 2001
    Date of Patent: March 26, 2002
    Assignee: Avecia Limited
    Inventors: John Crosby, Kevin Douglas Bailey, Michael John Monteith
  • Patent number: 6300522
    Abstract: A process is provided for the preparation of compounds of Formula (1): wherein X1 and X2 are each independently H, Cl or F, provided that at least one of X1 and X2 is Cl or F; one of R1 and R2 is H and the other is OH; and R5 is an unsubstituted alkyl, preferably a C1-6 alkyl, group.
    Type: Grant
    Filed: November 29, 2000
    Date of Patent: October 9, 2001
    Assignee: Avecia Limited
    Inventors: John Crosby, Kevin Douglas Bailey, Michael John Monteith
  • Patent number: 6261830
    Abstract: An enzymatic process for preparing amides of Formula I wherein X, E and * have the meanings defined in the specification. Chiral intermediates useful for preparing compound of Formula I and enzymatic processes for preparing such chiral intermediates are also described.
    Type: Grant
    Filed: May 31, 2000
    Date of Patent: July 17, 2001
    Assignee: Zeneca LTD
    Inventors: John Crosby, John David Pittam, Robert Antony Holt
  • Patent number: 6110729
    Abstract: A stereoselective method for making compounds of Formula VIII ##STR1## wherein A and * are as defined in the specification. Enzymic processes and intermediates useful for preparing compound of Formula VIII are disclosed.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: August 29, 2000
    Assignee: Zeneca Limited
    Inventors: John Crosby, John David Pittam, Robert Antony Holt
  • Patent number: 5989509
    Abstract: A process for purifying elemental phosphorus that contains antimony using an oxidizer, such as hydrogen peroxide, peroxymonosulfate, peroxydisulfate, or a hypochlorite, in a two phase system containing water and phosphorus as the two liquids. A purified elemental phosphorus having 200 ppb or less antimony content.
    Type: Grant
    Filed: June 9, 1997
    Date of Patent: November 23, 1999
    Assignee: EMC Corporation
    Inventors: Louis T. Gunkel, John Crosby, Theodore F. Munday, Paul J. Beck
  • Patent number: 5670662
    Abstract: A process for the separation of at least one isomer from a mixture of isomers of a tetrahydropyran-2-one, having at least two chiral centres which comprises selective reaction of at least one isomer with a reagent catalysed by a hydrolase enzyme whereby at least one isomer is preferentially converted into a distinct chemical species from the other isomers so that it is susceptible of separation by an appropriate chemical or physical separation process in which the tetrahydropyran-2-one is of Formula (1): ##STR1## wherein: Z is --H or a protecting group susceptible of reaction with the reagent under the influence of the enzyme; andY is formyl or protected formyl.
    Type: Grant
    Filed: March 28, 1996
    Date of Patent: September 23, 1997
    Assignee: Zeneca Limited
    Inventors: John Crosby, Andrew Blacker, John Albert Leslie Herbert