Patents by Inventor John Crowley
John Crowley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240099734Abstract: Apparatuses, capacitor arrays, and methods for generating therapeutic compressed acoustic waves (e.g., shock waves). In the apparatuses and at least some of the methods, a plurality of electrodes can disposed in a chamber that is defined by a housing and configured to be filled with liquid, and a plurality of capacitors can be electrically connected to the electrodes and can be carried by (e.g., physically coupled to) the housing. Voltage pulses can be applied simultaneously to the plurality of electrodes (e.g., to begin to vaporize and ionize portions of the liquid to provide at least one inter-electrode conductive path between the plurality of electrodes) and to the capacitors to charge the plurality of capacitors). The plurality of capacitors can be configured to, upon reaching a threshold charge, discharge to the plurality of electrodes (e.g.Type: ApplicationFiled: November 8, 2023Publication date: March 28, 2024Inventors: Christopher C. Capelli, Michael Kishnevsky, Daniel Masse, John Summerson, David W. Robert, Walter Klemp, Robert Crowley
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Publication number: 20240065716Abstract: A surgical device includes a pair of jaws for manipulating tissue disposed therebetween; a housing and a hemostat style gripping mechanism; an elongated shaft positioned between the housing and the pair of jaws and defining a longitudinal axis; and a pull tube at least partially disposed within the elongated shaft. The hemostat style gripping mechanism comprises a linkage system configured to move the jaws between an open position and an approximated position, the linkage system comprises a first shank having distal end rotatably coupled to the housing at a first fixed pivot point and a proximal end coupled to a first finger grip, a second shank having a distal end rotatably coupled to the housing at a second fixed pivot point and a proximal end coupled to a second finger grip, and a slider link operatively coupled to the first shank and the second shank.Type: ApplicationFiled: October 26, 2023Publication date: February 29, 2024Applicant: BOLDER SURGICAL, LLCInventors: Nathan Steketee, Timothy Crowley, Christopher Deborski, Russell Hempstead, Ryan Smith, John Twomey
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Publication number: 20240010737Abstract: The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Additionally, the present invention further pertains to chromatographic procedures employed to successfully isolate the antibody product subject of the present disclosure.Type: ApplicationFiled: February 28, 2023Publication date: January 11, 2024Inventors: John Mattila, Xiaolin Tang, Hanne Bak, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Michelle LaFond, Andrew Tustian, Philip Mellors, John Hourihan, John Crowley, Laura Callinan, Shadia Abike Oshodi, Ashley Witmer, Daniel Corbett, James Reilly, Ankit Vartak, Mark Chiboroski, Alessandra Starling, Robert Stairs, Hai-Yuan Goh, Liam Nicholl, Aishling Conlon
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Publication number: 20230398315Abstract: A dry powder inhaler for delivering medicament from at least one medicament carrier having a plurality of spaced-apart medicament doses. The inhaler includes a housing having regions for accommodating unused and used portions of the medicament carrier, a mouthpiece component extending from the housing and through which a user is able to inhale, a dispensing mechanism arranged in the housing for moving a medicament dose of the medicament carrier to the dispensing position, and a mouthpiece cover being rotatably connected to the housing for sequential movement about a rotation axis from a first position in which the mouthpiece component is completely covered to a second position in which the mouthpiece component is completely covered, and from the second position to a third position in which the mouthpiece component is completely uncovered, the second position being between the first and third positions.Type: ApplicationFiled: August 11, 2023Publication date: December 14, 2023Inventors: Peter John CROWLEY, Jan Geert HAZENBERG, Daniel BUCK, Josh GOTTESMAN
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Publication number: 20230381432Abstract: Disclosed is a dry powder inhaler for delivering medicament from at least one blister pack, each blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhaler comprises: a housing for accommodating unused and used portions of the at least one blister pack together with a dispensing mechanism for simultaneously opening at least two blister pockets at a time; and a manifold component through which air can be drawn in use of the inhaler.Type: ApplicationFiled: August 15, 2023Publication date: November 30, 2023Inventors: Peter John CROWLEY, Jan Geert HAZENBERG, Daniel BUCK, Josh GOTTESMAN
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Publication number: 20230348532Abstract: The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Additionally, the present invention further pertains to chromatographic procedures employed to successfully isolate the antibody product subject of the present disclosure.Type: ApplicationFiled: February 28, 2023Publication date: November 2, 2023Inventors: John Mattila, Xiaolin Tang, Hanne Bak, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Michelle LaFond, Andrew Tustian, Philip Mellors, John Hourihan, John Crowley, Laura Callinan, Shadia Abike Oshodi, Ashley Witmer, Daniel Corbett, James Reilly, Ankit Vartak, Mark Chiboroski, Alessandra Starling, Robert Stairs, Hai-Yuan Goh, Liam Nicholl, Aishling Conlon
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Publication number: 20230331776Abstract: The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Additionally, the present invention further pertains to chromatographic procedures employed to successfully isolate the antibody product subject of the present disclosure.Type: ApplicationFiled: February 28, 2023Publication date: October 19, 2023Inventors: John Mattila, Xiaolin Tang, Hanne Bak, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Michelle LaFond, Andrew Tustian, Philip Mellors, John Hourihan, John Crowley, Laura Callinan, Shadia Abike Oshodi, Ashley Witmer, Daniel Corbett, James Reilly, Ankit Vartak, Mark Chiboroski, Alessandra Starling, Robert Stairs, Hai-Yuan Goh, Liam Nicholl, Aishling Conlon
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Publication number: 20230332201Abstract: The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Additionally, the present invention further pertains to chromatographic procedures employed to successfully isolate the antibody product subject of the present disclosure.Type: ApplicationFiled: February 28, 2023Publication date: October 19, 2023Inventors: John Mattila, Xiaolin Tang, Hanne Bak, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Michelle LaFond, Andrew Tustian, Philip Mellors, John Hourihan, John Crowley, Laura Callinan, Shadia Abike Oshodi, Ashley Witmer, Daniel Corbett, James Reilly, Ankit Vartak, Mark Chiboroski, Alessandra Starling, Robert Stairs, Hai-Yuan Goh, Liam Nicholl, Aishling Conlon
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Publication number: 20230332084Abstract: The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Additionally, the present invention further pertains to chromatographic procedures employed to successfully isolate the antibody product subject of the present disclosure.Type: ApplicationFiled: February 28, 2023Publication date: October 19, 2023Inventors: John Mattila, Xiaolin Tang, Hanne Bak, Shawn M. Lawrence, Amy Johnson, Meghan Casey, Michelle LaFond, Andrew Tustian, Philip Mellors, John Hourihan, John Crowley, Laura Callinan, Shadia Abike Oshodi, Ashley Witmer, Daniel Corbett, James Reilly, Ankit Vartak, Mark Chiboroski, Alessandra Starling, Robert Stairs, Hai-Yuan Goh, Liam Nicholl, Aishling Conlon
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Patent number: 11779715Abstract: Disclosed is a dry powder inhaler for delivering medicament from at least one blister pack, each blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhaler comprises: a housing for accommodating unused and used portions of the at least one blister pack together with a dispensing mechanism for simultaneously opening at least two blister pockets at a time; and a manifold component through which air can be drawn in use of the inhaler.Type: GrantFiled: October 18, 2022Date of Patent: October 10, 2023Assignee: NORTON (WATERFORD) LIMITEDInventors: Peter John Crowley, Jan Geert Hazenberg, Daniel Buck, Josh Gottesman
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Publication number: 20230287043Abstract: The present invention pertains to methods for manufacturing high titer antibody products. In particular, the invention pertains, in part, to improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Additionally, the present invention further pertains to chromatographic procedures employed to successfully isolate the antibody product subject of the present disclosure.Type: ApplicationFiled: February 28, 2023Publication date: September 14, 2023Inventors: John Mattila, Xiaolin Tang, Hanne Bak, Shawn M. Lawrence, Amy S. Johnson, Meghan Casey, Michelle LaFond, Andrew Tustian, Philip Mellors, John Hourihan, John Crowley, Laura Callinan, Shadia Abike Oshodi, Ashley Witmer, Daniel Corbett, James Reilly, Ankit Vartak, Mark Chiboroski, Alessandra Starling, Robert Stairs, Hai-Yuan Goh, Liam Nicholl, Aishling Conlon
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Publication number: 20230181845Abstract: A dry powder inhaler for delivering medicament from at least one medicament carrier having a plurality of spaced-apart medicament doses. The inhaler includes a housing having regions for accommodating unused and used portions of the medicament carrier, a mouthpiece component extending from the housing and through which a user is able to inhale, a dispensing mechanism arranged in the housing for moving a medicament dose of the medicament carrier to the dispensing position, and a mouthpiece cover being rotatably connected to the housing for sequential movement about a rotation axis from a first position in which the mouthpiece component is completely covered to a second position in which the mouthpiece component is completely covered, and from the second position to a third position in which the mouthpiece component is completely uncovered, the second position being between the first and third positions.Type: ApplicationFiled: July 26, 2022Publication date: June 15, 2023Inventors: Peter John CROWLEY, Jan Geert HAZENBERG, Daniel BUCK, Josh GOTTESMAN
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Publication number: 20230103671Abstract: Methods for characterizing mechanical properties of cells at different stress levels. The disclosed inventions can determine the impact of shear stress on cells in bioproduction processes.Type: ApplicationFiled: September 30, 2022Publication date: April 6, 2023Inventors: Ian O'Shea, John Crowley, Martin Power, Alan Ronan
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Publication number: 20230097991Abstract: Disclosed is a dry powder inhaler for delivering medicament from at least one blister pack, each blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhaler comprises: a housing for accommodating unused and used portions of the at least one blister pack together with a dispensing mechanism for simultaneously opening at least two blister pockets at a time; and a manifold component through which air can be drawn in use of the inhaler.Type: ApplicationFiled: October 18, 2022Publication date: March 30, 2023Inventors: Peter John CROWLEY, Jan Geert HAZENBERG, Daniel BUCK, Josh GOTTESMAN
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Publication number: 20230095950Abstract: Disclosed are dry powder inhalers for delivering medicament to a user from a blister pack, the blister pack having a plurality of spaced-apart blister pockets containing doses of the medicament. The inhalers comprise: a housing for accommodating unused and used portions of the blister pack together with a dispensing mechanism for selectively opening the blister pockets; and a manifold component through which air can be drawn in use of the inhaler.Type: ApplicationFiled: October 19, 2022Publication date: March 30, 2023Inventors: Peter John CROWLEY, Jan Geert HAZENBERG, Daniel BUCK, Josh GOTTESMAN
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Publication number: 20230102408Abstract: Provided is a blister pack for a dry powder inhaler, which dry powder inhaler is configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament. The first and second powder medicaments are contained within blister pockets defined in a strip. A series of blister pockets is defined in the strip, which series extends linearly along the length of the strip. The first and second powder medicaments are contained in blister pockets, e.g. respective blister pockets, of the series. Alternatively or additionally, each of the blister pockets is elongated such as to have a largest dimension parallel with the length of the strip. These measures, either individually or in combination, enable minimizing of the width of the strip in spite of the strip accommodating both the first and second powder medicaments.Type: ApplicationFiled: November 4, 2022Publication date: March 30, 2023Applicant: Norton (Waterford) LimitedInventors: Peter John Crowley, Jan Geert Hazenberg, Daniel Buck, Christopher David Edlin, Hardik Kirtikumar Shah
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Publication number: 20230090912Abstract: The present inventions provide methods to control the heterogeneity of Fc-containing proteins, such as antibodies produced in cell culture, particularly mammalian cell culture by controlling culture pCO2, as well as products produced by these methods. Among other things, the inventions provide for lowering the percentage of acidic charge variants in antibody products. Proteins that comprise Fc moieties include but are not limited to Fc-containing proteins, such as antibodies and antibody derivatives, and fragments of both.Type: ApplicationFiled: September 20, 2022Publication date: March 23, 2023Inventors: Philip Mellors, John Hourihan, John Crowley
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Publication number: 20230052233Abstract: A dry powder inhaler for delivering medicament from at least one medicament carrier having a plurality of spaced-apart medicament doses. The inhaler includes a housing having regions for accommodating unused and used portions of the medicament carrier, a mouthpiece component extending from the housing and through which a user is able to inhale, a dispensing mechanism arranged in the housing for moving a medicament dose of the medicament carrier to the dispensing position, and a mouthpiece cover being rotatably connected to the housing for sequential movement about a rotation axis from a first position in which the mouthpiece component is completely covered to a second position in which the mouthpiece component is completely covered, and from the second position to a third position in which the mouthpiece component is completely uncovered, the second position being between the first and third positions.Type: ApplicationFiled: July 26, 2022Publication date: February 16, 2023Inventors: Peter John CROWLEY, Jan Geert HAZENBERG, Daniel BUCK, Josh GOTTESMAN
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Patent number: 11524128Abstract: Provided is a blister pack for a dry powder inhaler configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament. The first and second powder medicaments are contained within blister pockets defined in a strip. A series of blister pockets is defined in the strip, which series extends linearly along the length of the strip. The first and second powder medicaments are contained in blister pockets of the series. Alternatively or additionally, each of the blister pockets is elongated such as to have a largest dimension parallel with the length of the strip. These measures, either individually or in combination, enable minimizing of the width of the strip in spite of the strip accommodating both the first and second powder medicaments.Type: GrantFiled: July 2, 2021Date of Patent: December 13, 2022Assignee: NORTON (WATERFORD) LIMITEDInventors: Peter John Crowley, Jan Geert Hazenberg, Daniel Buck, Christopher David Edlin, Hardik Kirtikumar Shah
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Publication number: 20220347272Abstract: The present application provides for compositions comprising high concentrations of acid ?-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.Type: ApplicationFiled: March 21, 2022Publication date: November 3, 2022Inventors: Kenneth Valenzano, John Crowley, Richie Khanna, John Flanagan