Abstract: The present application provides for compositions comprising high concentrations of acid a-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: Provided is a blister pack for a dry powder inhaler, which dry powder inhaler is configured to deliver a first powder medicament and a second powder medicament different from the first powder medicament. The first and second powder medicaments are contained within blister pockets defined in a strip. A series of blister pockets is defined in the strip, which series extends linearly along the length of the strip. The first and second powder medicaments are contained in blister pockets, e.g. respective blister pockets, of the series. Alternatively or additionally, each of the blister pockets is elongated such as to have a largest dimension parallel with the length of the strip. These measures, either individually or in combination, enable minimizing of the width of the strip in spite of the strip accommodating both the first and second powder medicaments.

Abstract: Disclosed is a thermocouple assembly having a resilient mount; a buffer having a first side and a second side, with the buffer first side connecting with the resilient mount; an insulator having a first side and a second side, with the insulator first side connecting with the buffer second side; and a thermocouple having a first side and a second side, the thermocouple first side connecting with the insulator second side, and the thermocouple second side being configured to be in thermal contact with an object to be measured.

Abstract: The present application provides for compositions comprising high concentrations of acid a-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: The present application provides for compositions comprising high concentrations of acid a-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: Disclosed is a thermocouple assembly having a resilient mount; a buffer having a first side and a second side, with the buffer first side connecting with the resilient mount; an insulator having a first side and a second side, with the insulator first side connecting with the buffer second side; and a thermocouple having a first side and a second side, the thermocouple first side connecting with the insulator second side, and the thermocouple second side being configured to be in thermal contact with an object to be measured.

Abstract: The present application provides for compositions comprising high concentrations of acid a-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: The present application provides for compositions comprising high concentrations of acid a-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: The present application provides for compositions comprising high concentrations of acid ?-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: A modular, portable writing and projection system having a variable curvature is disclosed. The system uses dry erase boards, chalk or black boards, or other flexible panels having at least one writing surface. The panels have edges for joining to posts. The system combines panels to form a large, modular system for use at meetings, gatherings or other assemblies. The system allows a large number of users to contribute to a presentation, and also allows users to view the presentation. Because the panels are flexible, the system may be curved, allowing more panels to be mounted, used, written on and viewed, within limited space. The panels may be used in either a convex or concave manner, i.e., curved in or curved out, as desired. The resistance of the panels to remaining in a curved state is overcome by feet on the posts and braking or holding devices on the feet.

Abstract: The present application provides for compositions comprising high concentrations of acid ?-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: The present application provides for compositions comprising high concentrations of acid ?-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: The invention relates to a process for the culturing of cells by continuous perfusion culturing of a cell culture comprising cell culture medium and cells, wherein cell culture medium is added to the cell culture, the cell culture is circulated over a filter module comprising hollow fibers resulting in an outflow of liquid having a lower cell density than the cell culture and the flow within the filter module is an alternating tangential flow. Preferably, culture medium is added at a particular perfusion rate and/or biomass is removed form the culture at least once. The method is especially suitable for the culturing of aggregating cells. The invention also relates to such a process wherein a biological substance, preferably an antibody, is produced by the cells, which biological substance may be further purified in downstream processing.

Abstract: The present application provides for compositions comprising high concentrations of acid ?-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: The present application provides for compositions comprising high concentrations of acid ?-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.

Abstract: The invention relates to a process for the culturing of cells by continuous perfusion culturing of a cell culture comprising cell culture medium and cells, wherein cell culture medium is added to the cell culture, the cell culture is circulated over a filter module comprising hollow fibers resulting in an outflow of liquid having a lower cell density than the cell culture and the flow within the filter module is an alternating tangential flow. Preferably, culture medium is added at a particular perfusion rate and/or biomass is removed form the culture at least once. The method is especially suitable for the culturing of aggregating cells. The invention also relates to such a process wherein a biological substance, preferably an antibody, is produced by the cells, which biological substance may be further purified in downstream processing.

Abstract: A modular collaborative panel system intended for use on walls, frames and stands is disclosed. The system uses dry erase boards, chalk or black boards, or other panels having at least one writing surface. The panels have notches or cut-outs on each side so the panels can be mounted to a wall or a frame using pegs. The system combines panels in rows or columns, or both, to form a large, modular system for use at meetings, gatherings or other assemblies. The system allows a large number of users to contribute to a presentation, and also allows users to view the presentation.

Abstract: The invention is directed to a low humidity cure moisture curable coating composition which includes a moisture cure binder component that includes: a moisture curable binder material and at least one organic solvent; and a humectant component that includes a slow evaporating volatile humectant; wherein the humectant is present in an amount sufficient to increase the cure rate of the coating and to provide a cured coating having acceptable mechanical and cosmetic properties at a relative humidity of 50% or lower; and the invention is also directed to a method for curing moisture curable coating compositions under low humidity conditions.

Abstract: The invention relates to a process for the culturing of cells by continuous perfusion culturing of a cell culture comprising cell culture medium and cells, wherein cell culture medium is added to the cell culture, the cell culture is circulated over a filter module comprising hollow fibers resulting in an outflow of liquid having a lower cell density than the cell culture and the flow within the filter module is an alternating tangential flow. Preferably, culture medium is added at a particular perfusion rate and/or biomass is removed form the culture at least once. The method is especially suitable for the culturing of aggregating cells. The invention also relates to such a process wherein a biological substance, preferably an antibody, is produced by the cells, which biological substance may be further purified in downstream processing.

Abstract: A report card provides a supervisor or master account holder (e.g., a parent) with information about the activities of an individual or sub-account user (e.g., a child). For example, the report card may include a list of the sites (e.g., content identifiers and/or uniform resource locators) that an individual has visited or attempted to visit. Other information (e.g., e-mail and address book activity and instant messaging and contact list activity) also may be provided in addition to tools that allow the master account holder to access information about the activities and to adjust parental controls for the activities.