Abstract: This application discloses an advanced design method for customized RCP, (cRCP), with one or more made-to-order reinforcement cages supporting one or more wall-encapsulated heat-exchange channels, cast with special-batch (SB) concrete having additions of fine-disperse CaCO3 and particular polymer fibers; the resulting Single- and DoubleEPipe sections especially adapted for heat exchange with pipe-internal wastestreams and/or groundwater and including provisions for an optional graywater accumulator for efficient recapture of both water and energy.

Abstract: A movement detection device includes a signal transmission device configured to transmit a radar signal transmission toward a target area and to receive reflected radar signals, and a signal analysis device configured to analyze the reflected radar signals to detect a movement in the target area that is indicative of micro-shivering. In response to detecting the micro-shivering, the movement detection device generates an alarm.

Abstract: This application discloses an advanced design method for customized RCP, (cRCP), with one or more made-to-order reinforcement cages supporting one or more wall-encapsulated heat-exchange channels, cast with special-batch (SB) concrete having additions of fine-disperse CaCO3 and particular polymer fibers; the resulting Single- and DoubleEPipe sections especially adapted for heat exchange with pipe-internal wastestreams and/or groundwater and including provisions for an optional graywater accumulator for efficient recapture of both water and energy.

Abstract: A method for heat exchange with a heat transfer medium including providing a ground loop circuit through which the heat transfer medium is circulatable. The circuit includes an end portion, positioned proximal to a heat exchanger, one or more pipe portions having embedded parts thereof positioned in pipe bodies. Each pipe body defines a conduit therein through which a fluid is flowable, and has an exterior surface engaged with ground material. The method also includes circulating the heat transfer medium through the ground loop circuit, to permit heat transfer between the heat transfer medium moving through the embedded part and the fluid in the conduit, and heat transfer between the heat transfer medium moving through the embedded part and the ground material engaged with the pipe body.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides methods of treating a disease selected from systemic sclerosis, rheumatoid arthritis, mastocytosis, and chronic eosinophilic leukemia comprising administering biaryl meta-pyrimidine compounds having the general structure (A) to a subject in need thereof. The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the JAK kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.

Abstract: Provided herein are method of treating, ameliorating, or delaying at least one symptom of a genetic blood disorder, e.g. sickle cell disorder or thalassemia, in a patient in need thereof, comprising administering a therapeutically effective amount of a Jak2 inhibitor. Also provided in part is a method of reducing an enlarged spleen in a patient suffering from thalassemia, comprising administering a therapeutically effective amount of a Jak2 inhibitor.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

Abstract: Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases, inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: A heat exchange system including a heat pump assembly for controlling an indoor fluid's temperature having a heat exchanger with a heat exchange fluid circulatable therein and one or more elongate pipe bodies defining one or more conduits therein in which a fluid is receivable. The system includes one or more ground loop circuits through which a heat transfer medium is circulated. The ground loop circuit includes one or more pipe portions at least partially engaged with the pipe body. The pipe portion is at least partially located proximal to the conduit for heat exchange between the fluid in the conduit and the heat exchange medium in the pipe portion, and the pipe portion is at least partially located proximal to the exterior surface for heat exchange between the ground material and the heat exchange medium in the pipe portion.

Abstract: The invention provides methods of treating a disease selected from systemic sclerosis, rheumatoid arthritis, mastocytosis, and chronic eosinophilic leukemia comprising administering biaryl meta-pyrimidine compounds having the general structure (A) to a subject in need thereof. The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the JAK kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides biaryl meta-pyrimidine compounds having the general structure (A). The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the Jak kinase family, and various other specific receptor and non-receptor kinases.

Abstract: The invention provides benzotriazine compounds having formula (I). The benzotriazine compounds of the invention are capable of inhibiting kinases, such members of the Src kinase family, and various other specific receptor and non-receptor kinases.