Abstract: Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases , inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

Abstract: Compositions and methods and are provided for treating disorders associated with compromised vasculostasis. Invention methods and compositions are useful for treating a variety of disorders including for example, stroke, myocardial infarction, cancer, ischemia/reperfusion injury, autoimmune diseases such as rheumatoid arthritis, eye diseases such as retinopathies or macular degeneration or other vitreoretinal diseases , inflammatory diseases, vascular leakage syndrome, edema, transplant rejection, adult/acute respiratory distress syndrome (ARDS), and the like.

Abstract: An endless media filtration system includes a housing with a pool forming assembly mounted between a pair of side walls. The pool forming assembly includes a central shaft with two spaced-apart containment discs rotatably mounted on the shaft between the side walls. An endless loop filter media belt is supported on an endless loop carrier belt and includes an upper run which is pressed against the peripheral edges of the discs to form a generally semicircular shaped pool along bottom arcs of the discs. A separation pan is located between upper and lower runs of the carrier belt to direct filtered liquid to one side of the carrier belt and out the bottom of the housing. A backwash assembly includes a first spray rod spraying air through the filter media, a second spray rod spraying water through the filter media, and a third spray rod spraying air through the filter media after the filter media has passed under the second spray rod.

Abstract: A gravity liquid filtration apparatus includes a housing with a pool forming assembly mounted between a pair of side walls in the housing. The pool forming assembly includes a central shaft with a pair of spaced-apart discs rotatably mounted on the shaft between the side walls. A filter media is supported on an endless loop carrier belt, and pressed against the peripheral edges of the containment discs along bottom arcs thereof to form a generally semi-cylindrical shaped pool. A liquid inflow assembly on the housing includes a delivery head with a nozzle portion having an elongated mouth aimed downwardly to discharge liquid onto a downwardly sloped portion of the filter media. A box is formed in the delivery head above the nozzle of a size to permit large objects such as pens and pencils to fall flat and be discharged through the mouth of the nozzle.

Abstract: Pharmaceutical compositions comprising a compound of formula (I) and at least one other anthelmintically active compound, being an avermectin or a milbemycin, are useful in the treatment of helminthiasis. In formula (I): R is optionally substituted phenyl, C.sub.3-8 cycloalkyl, C.sub.5-8 cycloalkenyl, C.sub.1-8 straight or branched chain alkyl, C.sub.2-8 straight or branched alkenyl, a 5- or 6-membered heterocyclyl, or optionally substituted phenyl C.sub.1-4 alkyl; each of Y and Z, which may be the same or different, is oxygen or sulfur; and X is a bond, a methylene group (--CH.sub.2 --), or oxygen.

Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained from many organisms so that it shows a synergistic antibacterical effect when combined with .beta.-lactam antibiotics.

Abstract: It has been found that an antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms and when pure this antibiotic is an extremely potent inhibitor of many .beta.-lactamases. This antibiotic which we designate MM 4550A may be obtained in substantially pure form by the chromatographic purification of the crude antibacterial complex obtained from the culture medium.

Abstract: It has been found that a novel antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms. In addition to being a potent antibiotic this new material which we have designated MM 13902 acts synergistically with penicillins and cephalosporins.

Abstract: It has been found that a novel antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms. In addition to being a potent antibiotic this new material which we have designated MM 13902 acts synergistically with penicillins and cephalosporins.

Abstract: It has been found that an antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms and when pure this antibiotic is an extremely potent inhibitor of many .beta.-lactamases. This antibiotic which we designate MM 4550A may be obtained in substantially pure form by the chromatographic purification of the crude antibacterial complex obtained from the culture medium.

Abstract: It has been found that a novel antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms. In addition to being a potent antibiotic this new material which we have designated MM 13902 acts synergistically with penicillins and cephalosporins.

Abstract: It has been found that an antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms and when pure this antibiotic is an extremely potent inhibitor of many .beta.-lactamases. This antibiotic which we designate MM 4550A may be obtained in substantially pure form by the chromatographic purification of the crude antibacterial complex obtained from the culture medium.

Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained from many organisms so that it shows a synergistic antibacterial effect when combined with .beta.-lactam antibiotics.

Abstract: It has been found that an antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms and when pure this antibiotic is an extremely potent inhibitor of many .beta.-lactamases. This antibiotic which we designate MM 4550A may be obtained in substantially pure form by the chromatographic purification of the crude antibacterial complex obtained from the culture medium.

Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained from may organisms so that it shows a synergistic antibacterial effect when combined with .beta.-lactam antibiotics.

Abstract: A novel antibiotic designated herein MM 17880 may be obtained from the cultivation of strains of Streptomyces olivaceus and related organisms. In addition to being potent antibacterial agents, MM 17880 and its salts inhibit .beta.-lactamase obtained fromm many organisms so that it shows a synergistic antibacterial effect when combined with .beta.-lactam antibiotics.

Abstract: It has been found that a novel antibiotic can be obtained by the fermentation of certain strains of Streptomyces olivaceus and related organisms. In addition to being a potent antibiotic this new material which we have designated MM13902 acts synergistically with penicillins and cephalosporins.