Abstract: In some examples, a structure is contacted with polynucleotides having a variety of lengths and each including first and second adapters. The structure includes a substrate including first and second regions spaced apart from one another by a gap of at least 100 nm, a first set of capture primers coupled to the first region of the substrate, and a second set of capture primers coupled to the second region of the substrate. The first adapter of the polynucleotide is hybridized to a capture primer of the first set of capture primers. Based on that polynucleotide being sufficiently long to bridge the gap, it is amplified using the first and second sets of capture primers. Based upon that polynucleotide being insufficiently long to bridge the gap, it is not amplified. Optionally, a wall may be disposed in the gap.

Abstract: Techniques (e.g., methods, systems, devices) for receiving, from the lidar device, a measurement of the inertial measurement sensor. The techniques further including determining, using the measurement, at least one angle of a pitch angle or a roll angle of the lidar device. The techniques further including fixing the at least one angle of the lidar device in a graphical user interface that displays a location of the lidar device and providing one or more control elements in the graphical user interface that enable a user to specify one or more other degrees of freedom of the lidar device.

Abstract: A system and method for controlled fluid handling and processing of singulated biosensors. The system includes a consumable for mounting and protecting biosensors.

Abstract: Assemblies, systems, and methods for isolation of target material are provided. In various embodiments, an assembly for target material isolation includes a housing having an upper portion and a lower portion together defining an inner chamber. The inner chamber includes a semi-toroidal shape and the semi-toroidal shape defines a longitudinal axis. The assembly further includes one or more fluidic connection from the exterior of the housing to the inner chamber. An isolation material (e.g., polymer wool and/or magnetic beads) may be disposed within the inner chamber. A system includes a configured to fit at least a portion of the housing and releasably couple the assembly. Upon activation of the motor, the assembly may rotate about the longitudinal axis. An angle of the platform may be adjustable to thereby change the angle of the longitudinal axis about which the assembly rotates.

Abstract: Provided is an effective amount of a desialylation agent and an effective amount of an anti CD38 antibody for use in the treatment of multiple myeloma. This results in potentiated primary NK cell activity against the multiple myeloma cell. Also envisaged is a method of treating multiple myeloma in a subject in need thereof.

Abstract: Described herein are purge swab apparatuses, purge swabs kits, and methods for collecting a sample using a purge swab. In various embodiments, a purge swab includes an elongated body having a proximal end, a distal end, and a length therebetween. The purge swab further includes a swab head having a proximal end and a distal end wherein the proximal end of the swab head is attached to the distal end of the elongated body and the swab head includes a plurality of openings. The purge swab optionally includes a lumen extending from the proximal or distal end of the elongated body into at least a portion of the swab head, and the lumen is in fluidic communication with the plurality of openings.

Abstract: A system and method for controlled fluid handling and processing of singulated biosensors. The system includes a consumable for mounting and protecting biosensors.

Abstract: Assemblies, systems, and methods for isolation of target material are provided. In various embodiments, an assembly for target material isolation includes a housing having an upper portion and a lower portion together defining an inner chamber. The inner chamber includes a semi-toroidal shape and the semi-toroidal shape defines a longitudinal axis. The assembly further includes one or more fluidic connection from the exterior of the housing to the inner chamber. An isolation material (e.g., polymer wool and/or magnetic beads) may be disposed within the inner chamber. A system includes a configured to fit at least a portion of the housing and releasably couple the assembly. Upon activation of the motor, the assembly may rotate about the longitudinal axis. An angle of the platform may be adjustable to thereby change the angle of the longitudinal axis about which the assembly rotates.

Abstract: Assemblies, systems, and methods for isolation of target material are provided. In various embodiments, an assembly for target material isolation includes a housing having an upper portion and a lower potion together defining an inner chamber. The inner chamber includes a semi-toroidal shape and the semi-toroidal shape defines a longitudinal axis. The assembly further includes one or more fluidic connection from the exterior of the housing to the inner chamber. An isolation material (e.g., polymer wool and/or magnetic beads) may be disposed within the inner chamber. A system includes a configured to fit at least a portion of the housing and releasably couple the assembly. Upon activation of the motor, the assembly may rotate about the longitudinal axis. An angle of the platform may be adjustable to thereby change the angle of the longitudinal axis about which the assembly rotates.

Abstract: The present disclosure relates generally to a retractor device for allowing visible access to the surgical site. According to particular embodiments, the present retractor may include two portions: an integral arm portion at one end and a textured surface potion at the opposite end. In some embodiments, the integral arm portion may be positioned inside the body cavity of the patient to restrain and/or occlude targeted organs during surgery to allow for increased visibility of other organs and/or portions of a patient during surgical procedures.

Abstract: At least one sensor is configured to detect a user aiming at a point and movement of the firearm. A processor is provided to process and analyse movement data obtained wherein the at least one sensor is adapted to measure a movement deviation from the line of sight between an eye of the user and the point of aim of the firearm. At least one electro-mechanical actuator to apply a correction to the barrel as to maintain aim on the intended point of aim.

Abstract: Luciferase polypeptides with improved light-emitting activity and their encoding nucleic acids are disclosed. These molecules are useful in a range of assays including luciferase-based gene reporter assays, bioluminescence resonance energy transfer assays, protein complementation assays and other applications in which luciferase enzymes are utilized as detectable and/or quantifiable labels. Methods and compositions for increasing the sensitivity and/or improving the kinetics of luciferase-catalyzed reactions as well as decreasing the impact of undesirable variables are also disclosed.

Abstract: Aspects of the present disclosure include a complete genomic analysis device and methods of use thereof for high throughput genomic analysis of biological samples.

Abstract: Complete nucleic acid library preparation devices are provided. Aspects of the devices include: a thermal chip module comprising multiple CLC reaction wells; one or more plate locations; a robotically controlled liquid handler configured to transfer liquid between the one or more plate locations and the thermal chip module; and a bulk reagent dispenser configured to access each CLC reaction well of the thermal chip module.

Abstract: The invention relates to an electronic wearable device designed to detect unintended movement that occurs immediately prior to a firing event of a gun. The wearable device encompasses at least one sensor, such as an accelerometer, a gyroscope and Electromyography (EMG), to detect a flinch movement that can occur prior to the event of a gun being fired. The user or firer can then be provided with real-time feedback on whether a flinch occurred or not during a firing practice. Feedback can be given to the user, in one embodiment, in the form of an audible tone or a vibrating motor in the wearable device.

Abstract: The present invention relates generally to constructs and their use in gene expression or gene regulation assays. More particularly, the present invention provides expression vectors and/or reporter vectors providing kinetics of protein expression with improved temporal correlation to promoter activity. Even more particularly, the invention provides expression vectors comprising a transcribable polynucleotide which comprises a sequence of nucleotides encoding a RNA element that modulates the stability of a transcript corresponding to the transcribable polynucleotide. The present invention provides, inter alia, novel vectors, useful for identifying and analysing cis- and trans-acting regulatory sequences/factors as well as vectors and genetically modified cell lines or organisms that are particularly useful for drug screening and drug discovery.

Abstract: Aspects of the present disclosure include a complete genomic analysis device and methods of use thereof for high throughput genomic analysis of biological samples.

Abstract: Complete nucleic acid library preparation devices are provided. Aspects of the devices include: a thermal chip module comprising multiple CLC reaction wells; one or more plate locations; a robotically controlled liquid handler configured to transfer liquid between the one or more plate locations and the thermal chip module; and a bulk reagent dispenser configured to access each CLC reaction well of the thermal chip module.