Abstract: The present invention is directed to the production, breeding and use of transgenic non-human animals such as mice in which specific genes or portions of genes have been replaced by homologues from another animal to make the physiology of the animals so modified more like that of the other animal with respect to drug pharmacokinetics and metabolism. The invention also extends to the use of the genetically modified non-human animals of the invention for pharmacological and/or toxicological studies.

Abstract: The present invention relates generally to constructs and their use in gene expression or gene regulation assays. More particularly, the present invention provides expression vectors and/or reporter vectors providing kinetics of protein expression with improved temporal correlation to promoter activity. Even more particularly, the invention provides expression vectors comprising a transcribable polynucleotide which comprises a sequence of nucleotides encoding a RNA element that modulates the stability of a transcript corresponding to the transcribable polynucleotide. The present invention provides, inter alia, novel vectors, useful for identifying and analysing cis- and trans-acting regulatory sequences/factors as well as vectors and genetically modified cell lines or organisms that are particularly useful for drug screening and drug discovery.

Abstract: A multi-port receptacle assembly is provided having a housing forming multiple ports and having electrical connectors mounted within the ports so that upon assembly with a base via mounting features between the base and the housing a uniform multi-port assembly is provided that may be easily transported and installed to a motherboard.

Abstract: The mobile data collection system includes a positioning system, such as a Global Positioning System (GPS) receiver and/or an Inertial Navigation System (INS), to generate position and time data. A down looking line scan camera for mounting on a vehicle, obtains a series of line scan images of a path, such as a road. A data collection controller is connected to the positioning system and the line scan camera to associate the line scan images with the corresponding position and time data. A database stores the line scan images and associated corresponding position and time data. An image processor identifies and marks features in the line scan images.

Abstract: A communication device locates a preferable wireless service provider in a multi-service provider environment using a frequency band search schedule. Initially, the communications device registers with a less preferred service provider in a first frequency band. While remaining registered with the less preferred service provider, the device examines several frequency bands in the order specified by the frequency band search schedule. A frequency band is examined by dividing the frequency band into many sub-bands, and by locating the strongest signal above a threshold within the sub-band being examined. The examination continues until a second frequency band having a more preferred service provider is located. The communication device then registers with the more preferred service provider. The category of service provider may be identified and displayed on the communication device.

Abstract: The present invention relates generally to constructs and their use in gene expression or gene regulation assays. More particularly, the present invention provides expression vectors and/or reporter vectors providing kinetics of protein expression with improved temporal correlation to promoter activity. Even more particularly, the invention provides expression vectors comprising a transcribable polynucleotide which comprises a sequence of nucleotides encoding a RNA element that modulates the stability of a transcript corresponding to the transcribable polynucleotide. The present invention provides, inter alia, novel vectors, useful for identifying and analysing cis- and trans-acting regulatory sequences/factors as well as vectors and genetically modified cell lines or organisms that are particularly useful for drug screening and drug discovery.

Abstract: A hot fill container is provided having a base, a body portion connected to the base, a shoulder portion connected to the body portion, and a neck portion connected to the shoulder portion. At least two panels in the shoulder portion are adapted to flex to accommodate pressure changes within the hot fill container. A longitudinal strut between each of the at least two panels provides longitudinal support to the neck portion.

Abstract: The present invention relates generally to constructs and their use in gene expression or gene regulation assays. More particularly, the present invention provides expression vectors and/or reporter vectors providing kinetics of protein expression with improved temporal correlation to promoter activity. Even more particularly, the invention provides expression vectors comprising a transcribable polynucleotide which comprises a sequence of nucleotides encoding a RNA element that modulates the stability of a transcript corresponding to the transcribable polynucleotide. The present invention provides, inter alia, novel vectors, useful for identifying and analysing cis- and trans-acting regulatory sequences/factors as well as vectors and genetically modified cell lines or organisms that are particularly useful for drug screening and drug discovery.

Abstract: The present invention discloses the use of an electrolysis cell (30,40,50-52) to provide for super chlorination of cooling tower water. Halogens naturally present in the water are concentrated by evaporation and provide the starting material for the production of oxyhalite compounds (typically to a level of superchlorination) as a biocide. The biocide is recycled thereby avoiding the cost of chemicals. The level of atmospheric polluants, and particulate matter especially, is thought to be the determining factor in biocide consumption.

Abstract: The present invention provides the nucleotide and amino acid sequence of a previously unidentified erbB receptor target. The nucleotide and amino acid sequence is set out in the figure.

Abstract: The present invention provides the nucleotide and amino acid sequence of a previously unidentified erbB receptor target. The nucleotide and amino acid sequence is set out in the figure.

Abstract: An improved rupture disk assembly and methods and apparatuses for forming a rupture disk are disclosed. The rupture disk assembly includes a rupture disk having a flange connected to a dome-shaped rupturable portion by a transition area. The rupturable portion includes a structural apex formation at or near the apex of the dome and is configured to rupture when exposed to a fluid having a predetermined pressure. Preferably, a safety member is disposed adjacent the rupture disk. The safety member includes a hinge about which the disk bends when the disk ruptures. The present invention is also directed to an apparatus and method for consistently, accurately, and repeatably forming a structural apex formation in a rupture disk before the formation of to the rupture disk dome, during the formation of the rupture disk dome, and after the formation of the rupture disk dome.

Abstract: The present invention provides the nucleotide and amino acid sequence of a previously unidentified erbB receptor target.

Abstract: An improved rupture disk assembly and methods and apparatuses for forming a rupture disk are disclosed. The rupture disk assembly includes a rupture disk having a flange connected to a dome-shaped rupturable portion by a transition area. The rupturable portion includes a structural apex formation at or near the apex of the dome and is configured to rupture when exposed to a fluid having a predetermined pressure. Preferably, a safety member is disposed adjacent the rupture disk. The safety member includes a hinge about which the disk bends when the disk ruptures. The present invention is also directed to an apparatus and method for consistently, accurately, and repeatably forming a structural apex formation in a rupture disk before the formation of the rupture disk dome, during the formation of the rupture disk dome, and after the formation of the rupture disk dome.

Abstract: The present invention provides the nucleotide and amino acid sequence of a previously unidentified erbB receptor target. The nucleotide and amino acid sequence is set out in the figure.

Abstract: A recreational air board used for “surf-bouncing” on a trampoline. The board is made of at least one soft cushioning layer and a support layer. The cushioning layer provides protection against damage caused to the trampoline and other objects by impact with the board. The cushioning layer also minimizes the risk of injury to the user. The support layer provides stiffness to the board so that the board maintains its proper form. The board may be fastened to a user's feet by a pair of elastic cords. The elastic cords form loops to receive a user's feet and are attached to the board through openings in the board. The elastic cords can stretch to snugly fit different sized feet without the need for special boots and bindings.

Abstract: A novel polynucleotide molecule is disclosed which encodes a candidate effector protein for the Grb7 family of signalling proteins. Detection of the protein in a sample such as a homogenised tissue sample should provide a useful tumour marker and/or prognostic indicator for certain human cancers such as breast and prostate cancer.

Abstract: An improved rupture disk assembly and methods and apparatuses for forming a rupture disk are disclosed. The rupture disk assembly includes a rupture disk having a flange connected to a dome-shaped rupturable portion by a transition area. The rupturable portion includes a structural apex formation at or near the apex of the dome and is configured to rupture when exposed to a fluid having a predetermined pressure. Preferably, a safety member is disposed adjacent the rupture disk. The safety member includes a hinge about which the disk bends when the disk ruptures. The present invention is also directed to an apparatus and method for consistently, accurately, and repeatably forming a structural apex formation in a rupture disk before the formation of the rupture disk dome, during the formation of the rupture disk dome, and after the formation of the rupture disk dome.

Abstract: An improved rupture disk assembly and methods and apparatuses for forming a rupture disk are disclosed. The rupture disk assembly includes a rupture disk having a flange connected to a dome-shaped rupturable portion by a transition area. The rupturable portion includes a structural apex formation at or near the apex of the dome and is configured to rupture when exposed to a fluid having a predetermined pressure. Preferably, a safety member is disposed adjacent the rupture disk. The safety member includes a hinge about which the disk bends when the disk ruptures. The present invention is also directed to an apparatus and method for consistently, accurately, and repeatably forming a structural apex formation in a rupture disk before the formation of the rupture disk dome, during the formation of the rupture disk dome, and after the formation of the rupture disk dome.