Patents by Inventor John Diener
John Diener has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230340058Abstract: The present disclosure provides relaxin-2 fusion protein analogs with enhanced in vivo half-life and methods for making the same. Also disclosed herein are methods of treating relaxin-2-associated disorders or diseases using the relaxin-2 fusion protein analogs described herein.Type: ApplicationFiled: November 11, 2022Publication date: October 26, 2023Inventors: John DIENER, Andrew Kruse, Franz Gruswitz
-
Patent number: 10550391Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.Type: GrantFiled: August 20, 2018Date of Patent: February 4, 2020Assignee: Arrowhead Pharmaceuticals, Inc.Inventors: Antonin De Fougerolles, John Diener, Emma Hickman, Gregory Hinkle, Stuart Milstein, Anne-Marie Pulichino, Andrew Griffin Sprague
-
Publication number: 20180355362Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.Type: ApplicationFiled: August 20, 2018Publication date: December 13, 2018Inventors: Antonin De Fougerolles, John Diener, Emma Hickman, Gregory Hinkle, Stuart Milstein, Anne-Marie Pulichino, Andrew Griffin Sprague
-
Patent number: 10081811Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.Type: GrantFiled: July 27, 2017Date of Patent: September 25, 2018Assignee: Arrowhead Pharmaceuticals, Inc.Inventors: Antonin De Fougerolles, John Diener, Emma Hickman, Gregory Hinkle, Stuart Milstein, Anne-Marie Pulichino, Andrew Griffin Sprague
-
Publication number: 20170327829Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.Type: ApplicationFiled: July 27, 2017Publication date: November 16, 2017Inventors: Antonin De Fougerolles, John Diener, Emma Hickman, Gregory Hinkle, Stuart Milstein, Anne-Marie Pulichino, Andrew Griffin Sprague
-
Patent number: 9752152Abstract: The present disclosure relates to RNAi agents useful in methods of treating BetaENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.Type: GrantFiled: May 27, 2016Date of Patent: September 5, 2017Assignee: Arrowhead Pharmaceuticals, Inc.Inventors: Antonin De Fougerolles, John Diener, Emma Hickman, Gregory Hinkle, Stuart Milstein, Anne-Marie Pulichino, Andrew Griffin Sprague
-
Publication number: 20160272979Abstract: The present disclosure relates to RNAi agents useful in methods of treating BetaENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.Type: ApplicationFiled: May 27, 2016Publication date: September 22, 2016Inventors: Antonin De Fougerolles, John Diener, Emma Hickman, Gregory Hinkle, Stuart Milstein, Anne-Marie Pulichino, Andrew Griffin Sprague
-
Publication number: 20140182024Abstract: A new and distinctly salt and boron tolerant poplar tree cultivar named “RRR Yellow,” is particularly distinguishable by its ability to tolerate and grow in soil with high concentrations of salt, boron and selenium. The cultivar was originally discovered as a sport through stringent selection of cultivated poplar trees, and potentially from isolation of a single unique sapling or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “RRR Yellow” cultivar.Type: ApplicationFiled: December 26, 2012Publication date: June 26, 2014Inventors: Gary Banuelos, John Diener, James Prince
-
Patent number: 8598335Abstract: The present disclosure relates to RNAi agents useful in methods of treating Beta-ENaC-related diseases such as cystic fibrosis, pseudohypoaldosteronism type 1 (PHA1), Liddle's syndrome, hypertension, alkalosis, hypokalemia, and obesity-associated hypertension, using a therapeutically effective amount of a RNAi agent to Beta-ENaC.Type: GrantFiled: September 13, 2012Date of Patent: December 3, 2013Assignee: Novartis AGInventors: Antonin De Fougerolles, John Diener, Emma Hickman, Gregory Hinkle, Stuart Milstein, Anne-Marie Pulichino, Andrew Griffin Sprague
-
Patent number: 8598327Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diagnostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI.Type: GrantFiled: February 11, 2011Date of Patent: December 3, 2013Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Robert Schaub, Kathleen McGinness, Jennifer Nelson, Ryan Genga, Emily Waters, Jeffrey Kurz, John Diener
-
Publication number: 20130254957Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named “Seleno-Orange,” is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “Seleno-Orange” cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The “Seleno-Orange” cultivar has yellow flowers, mature green cladodes without glochids, and orange fruit.Type: ApplicationFiled: March 21, 2012Publication date: September 26, 2013Inventors: Gary Banuelos, John Leonard Freeman, John Diener
-
Publication number: 20130254958Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named “Seleno-Purple,” is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “Seleno-Purple” cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The “Seleno-Purple” cultivar has yellow flowers, mature green cladodes without glochids, and purple fruit.Type: ApplicationFiled: March 21, 2012Publication date: September 26, 2013Inventors: Gary Banuelos, John Leonard Freeman, John Diener
-
Publication number: 20130254956Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named “Seleno-Green,” is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “Seleno-Green” cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The “Seleno-Green” cultivar has yellow-orange flowers, mature green cladodes without glochids, and yellow-green fruit.Type: ApplicationFiled: March 21, 2012Publication date: September 26, 2013Inventors: Gary Banuelos, John Leonard Freeman, John Diener
-
Publication number: 20130254959Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named “Seleno-Red,” is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the “Seleno-Red” cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The “Seleno-Red” cultivar has orange-red flowers, mature green cladodes without glochids, and red-purple fruit.Type: ApplicationFiled: March 21, 2012Publication date: September 26, 2013Inventors: Gary Banuelos, John Leonard Freeman, John Diener
-
Patent number: 8461318Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diagnostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI.Type: GrantFiled: November 3, 2011Date of Patent: June 11, 2013Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Robert Schaub, Kathleen McGinness, Jennifer Nelson, Ryan Genga, Emily Waters, Jeffrey Kurz, John Diener
-
Patent number: PP24039Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Orange’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Orange’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Orange’ cultivar has yellow flowers, mature green cladodes without glochids, and orange fruit.Type: GrantFiled: March 21, 2012Date of Patent: November 26, 2013Assignees: California State University, Fresno, Red Rock Ranch, LLC, USDAInventors: Gary Banuelos, John Leonard Freeman, John Diener
-
Patent number: PP24052Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Red,’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Red’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Red’ cultivar has orange-red flowers, mature green cladodes without glochids, and red-purple fruit.Type: GrantFiled: March 21, 2012Date of Patent: December 3, 2013Assignees: California State University, Fresno, Red Rock Ranch, LLC, USDAInventors: Gary Banuelos, John Leonard Freeman, John Diener
-
Patent number: PP24053Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Green,’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Green’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Green’ cultivar has yellow-orange flowers, mature green cladodes without glochids, and yellow-green fruit.Type: GrantFiled: March 21, 2012Date of Patent: December 3, 2013Assignees: California State University, Fresno, Red Roche Ranch, LLC, USDAInventors: Gary Banuelos, John Diener, John Leonard Freeman
-
Patent number: PP24072Abstract: A new and distinctly salt and boron tolerant cultivar of prickly pear (Opuntia ficus-indica), named ‘Seleno-Purple,’ is particularly distinguishable by its ability to tolerate and grow in high concentration of salt, boron and selenium-laden soil. The cultigen was originally discovered by stringent selection of randomly harvested cladodes (modified stems) and potentially from isolation of a single unique cladode or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated into the ‘Seleno-Purple’ cultivar. The cladodes were originally randomly harvested from different individual plants and screened from within a naturally segregating wild population or accession. The ‘Seleno-Purple’ cultivar has yellow flowers, mature green cladodes without glochids, and purple fruit.Type: GrantFiled: March 21, 2012Date of Patent: December 10, 2013Assignees: California State University, Fresno, Red Rock Ranch, LLC, USDAInventors: Gary Banuelos, John Leonard Freeman, John Diener
-
Patent number: PP26125Abstract: A new and distinctly salt and boron tolerant poplar tree cultivar named ‘RRR Yellow’, is particularly distinguishable by its ability to tolerate and grow in soil with high concentrations of salt, boron and selenium. The ‘RRR Yellow’ cultivar was originally discovered as a naturally occuring branch sport through stringent selection of cultivated poplar trees, and potentially from isolation of a single unique sapling or sport that exhibited high levels of salt and boron tolerance necessary for survival, and then propagated.Type: GrantFiled: December 26, 2012Date of Patent: November 24, 2015Assignees: California State University, Fresno, RedRock Ranch, USDAInventors: Gary Banuelos, John Diener, James Prince