Patents by Inventor John Diener

John Diener has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • APTAMERS TO TISSUE FACTOR PATHWAY INHIBITOR AND THEIR USE AS BLEEDING DISORDER THEREAPEUTICS
    Publication number: 20120190834
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diagnostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI.
    Type: Application
    Filed: November 3, 2011
    Publication date: July 26, 2012
    Applicants: Baxter International Inc.
    Inventors: Robert Schaub, Kathleen McGinness, Jennifer Nelson, Ryan Genga, Emily Waters, Jeffrey Kurz, John Diener
  • APTAMERS TO TISSUE FACTOR PATHWAY INHIBITOR AND THEIR USE AS BLEEDING DISORDER THERAPEUTICS
    Publication number: 20110281938
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers that bind to TFPI, which are useful as therapeutics in and diagnostics of bleeding disorders and/or other diseases or disorders in which TFPI has been implicated. In addition, the TFPI aptamers may be used before, during and/or after medical procedures to reduce complications or side effects thereof. The invention further relates to materials and methods for the administration of aptamers that bind to TFPI.
    Type: Application
    Filed: February 11, 2011
    Publication date: November 17, 2011
    Applicants: Baxter Healthcare S.A., Baxter International Inc.
    Inventors: Robert Schaub, Kathleen McGinness, Jennifer Nelson, Ryan Genga, Emily Waters, Jeffrey Kurz, John Diener
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Patent number: 7803931
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: February 14, 2005
    Date of Patent: September 28, 2010
    Assignee: Archemix Corp.
    Inventors: Claude Benedict, John Diener, David Epstein, Dilara Grate, Sara Chesworth Keene, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman, Kristin Thompson, Charles Wilson, Anna J. Zoltoski
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Patent number: 7538211
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: May 26, 2009
    Assignee: Archemix Corp.
    Inventors: Claude Benedict, John Diener, David Epstein, Dilara Grate, Sara Chesworth Keene, Jeffrey Kurz, Markus Kurz, Thomas Greene McCauley, James Rottman, Kristin Thompson, Charles Wilson, Anna J. Zoltoski
  • Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics
    Publication number: 20090053138
    Abstract: Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination thereof with affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Application
    Filed: November 2, 2005
    Publication date: February 26, 2009
    Inventors: Jeffrey Preiss, Charles Wilson, Martin Stanton, John Diener, David Epstein, Dilara McCauley, Thomas McCauley
  • Materials and methods for the generation of fully 2'-modified nucleic acid transcripts
    Publication number: 20070117112
    Abstract: Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence.
    Type: Application
    Filed: June 30, 2006
    Publication date: May 24, 2007
    Inventors: John Diener, Anthony Keefe, Kristin Thompson, Chunhua Wang, Shuhao Zhu
  • Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
    Publication number: 20070066550
    Abstract: The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
    Type: Application
    Filed: March 7, 2005
    Publication date: March 22, 2007
    Inventors: John Diener, Alicia Ferguson, Nobuko Hamaguchi, Sara Keene, H.A. Lagasse, Pooja Sawhney, Kristin Thompson
  • Aptamer medicinal chemistry
    Publication number: 20070066551
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers useful as therapeutics, diagnostics and in research such as for target validation. The invention further relates to materials and methods for enhancing aptamers for use in therapeutics, diagnostics and research.
    Type: Application
    Filed: September 7, 2005
    Publication date: March 22, 2007
    Inventors: Anthony Keefe, Charles Wilson, John Diener, Markus Kurz
  • Stabilized aptamers to PSMA and their use as prostate cancer therapeutics
    Publication number: 20070041901
    Abstract: The present invention provides stabilized, high affinity nucleic acid ligands to PSMA. Methods for the identification and preparation of novel, stable, high affinity ligands to PSMA using the SELEX™ method with 2?-O-methyl substituted nucleic acids, and cell surface SELEX™ are described herein. Also included are methods and compositions for the treatment and diagnosis of disease characterized by PSMA expression, using the described nucleic acid ligands.
    Type: Application
    Filed: March 7, 2006
    Publication date: February 22, 2007
    Inventors: John Diener, Paul Hatala, Jess Wagner-Whyte, Charles Wilson
  • Nucleic acid ligands specific to immunoglobulin E and their use as atopic disease therapeutics
    Publication number: 20070009907
    Abstract: The invention discloses aptamers capable of binding to Immunoglobulin E (“IgE”) useful as therapeutics in and diagnostics of atopic disease and/or other diseases or disorders in which IgE has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to IgE.
    Type: Application
    Filed: April 26, 2005
    Publication date: January 11, 2007
    Inventors: Paula Burmeister, Sharon Cload, John Diener, Anthony Keefe, Sara Keene, Markus Kurz, H.A. Lagasse, Harold Marsh, Pooja Sawhney, Chunhua Wang
  • Aptamers to von Willebrand Factor and their use as thrombotic disease therapeutics
    Publication number: 20060264369
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.
    Type: Application
    Filed: January 12, 2006
    Publication date: November 23, 2006
    Inventors: John Diener, H.A. Lagasse, Claude Benedict
  • Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics
    Publication number: 20060193821
    Abstract: The present invention provides materials and methods to treat immune disease in which cytokines are involved in pathogenesis. The materials and methods of the present invention are useful in the treatment of autoimmune diseases. The materials and methods of the present invention are directed to nucleic acid ligands capable of binding to human IL-23 and/or human IL-12 cytokines and thus modulate their biological activity and are useful as therapeutic agents in immune, auto-immune and cancer therapeutics.
    Type: Application
    Filed: September 22, 2005
    Publication date: August 31, 2006
    Inventors: John Diener, David Epstein, Alicia Ferguson, Nobuko Hamaguchi, H.A. Lagasse, Shannon Pendergrast, Pooja Sawhney, Kristin Thompson
  • Aptamers to von Willebrand factor and their use as thrombotic disease therapeutics
    Publication number: 20060183702
    Abstract: The invention relates generally to the field of nucleic acids and more particularly to aptamers capable of binding to von Willebrand Factor useful as therapeutics in and diagnostics of thrombotic diseases and/or other diseases or disorders in which von Willebrand Factor mediated platelet aggregation has been implicated. The invention further relates to materials and methods for the administration of aptamers capable of binding to von Willebrand Factor.
    Type: Application
    Filed: September 7, 2005
    Publication date: August 17, 2006
    Inventors: John Diener, H.A. Lagasse, Claude Benedict
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Publication number: 20060105980
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: December 22, 2005
    Publication date: May 18, 2006
    Inventors: Claude Benedict, John Diener, David Epstein, Dilara Grate, Sara Keene, Jeffrey Kurz, Markus Kurz, Thomas McCauley, James Rottman, Kristin Thompson, Charles Wilson, Anna Zoltoski
  • Regulated aptamer therapeutics
    Publication number: 20060084109
    Abstract: Materials and methods of use thereof are presented for the treatment of diabetes and other diseases. Therapeutic compositions including regulated aptamer therapeutic compositions with specificity to components of diabetes disease are presented with methods of administering these therapeutic compositions.
    Type: Application
    Filed: November 30, 2005
    Publication date: April 20, 2006
    Inventors: David Epstein, Charles Wilson, John Diener
  • Aptamer therapeutics useful in the treatment of complement-related disorders
    Publication number: 20060018871
    Abstract: The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
    Type: Application
    Filed: February 14, 2005
    Publication date: January 26, 2006
    Inventors: Claude Benedict, John Diener, David Epstein, Dilara Grate, Sara Keene, Jeffrey Kurz, Markus Kurz, Thomas McCauley, James Rottman, Kristin Thompson, Charles Wilson, Anna Zoltoski
  • Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
    Publication number: 20050159351
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Application
    Filed: November 2, 2004
    Publication date: July 21, 2005
    Inventors: Dilara Grate, John Diener, Charles Wilson, Thomas McCauley
  • Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics
    Publication number: 20050124565
    Abstract: Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
    Type: Application
    Filed: June 21, 2004
    Publication date: June 9, 2005
    Inventors: John Diener, David Epstein, Alicia Ferguson, Dilara Grate, Anthony Keefe, Thomas McCauley, Jeffrey Preiss, Martin Stanton, Charles Wilson