Patents by Inventor John E. Monahan

John E. Monahan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of Treating Gastrointestinal Stromal Tumors
    Publication number: 20150202203
    Abstract: The present invention relates to a method of treating gastrointestinal stromal tumors (GIST), especially GIST, which is progressing after imatinib therapy or after imatinib and sunitinib therapy, using a combination comprising (a) a c-kit inhibitor and (b) a dual KIT inhibitor and FGFR inhibitor or FGFR inhibitor.
    Type: Application
    Filed: April 12, 2013
    Publication date: July 23, 2015
    Applicant: Novartis AG
    Inventors: John E Monahan, Fang Li
  • Method of Treating Gastrointestinal Stromal Tumors
    Publication number: 20140288073
    Abstract: The present invention relates to a method of treating gastrointestinal stromal tumors (GIST), especially GIST, which is progressing after imatinib therapy or after imatinib and sunitinib therapy, using a combination comprising (a) a c-kit inhibitor and (b) a PI3K inhibitor or FGFR inhibitor.
    Type: Application
    Filed: October 24, 2012
    Publication date: September 25, 2014
    Applicant: Novartis AG
    Inventors: John E. Monahan, Fang Li
  • SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS
    Publication number: 20140200217
    Abstract: The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors.
    Type: Application
    Filed: January 24, 2014
    Publication date: July 17, 2014
    Inventors: Marion Dorsch, John E. Monahan, Michael Patrick Morrissey, Shifeng Pan, Juliet Williams
  • Smoothened antagonism for the treatment of hedgehog pathway-related disorders
    Patent number: 8778927
    Abstract: The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: July 15, 2014
    Assignee: Novartis AG
    Inventors: Marion Dorsch, John E. Monahan, Michael Patrick Morrissey, Shifeng Pan, Juliet Williams
  • COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF CERVICAL CANCER
    Publication number: 20120264625
    Abstract: The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided.
    Type: Application
    Filed: October 14, 2011
    Publication date: October 18, 2012
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: John E. Monahan, Xumei Zhao, Yan Chen, Karen Glatt, Shubhangi Kamatkar
  • NOVEL GENES, COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF CERVICAL CANCER
    Publication number: 20120064548
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.
    Type: Application
    Filed: October 12, 2011
    Publication date: March 15, 2012
    Applicant: MILLENNIUM PHARMACEUTICALS, INC.
    Inventors: Robert Schlegel, Yan Chen, Xumei Zhao, John E. Monahan, Shubhangi Kamatkar, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersh
  • Genes, compositions, kits, and methods for identification, assessment, prevention and therapy of cervical cancer
    Patent number: 8062892
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.
    Type: Grant
    Filed: June 14, 2010
    Date of Patent: November 22, 2011
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Robert Schlegel, Yan Chen, Xumei Zhao, John E. Monahan, Shubhangi Kamatkar, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch
  • SMOOTHENED ANTAGONISM FOR THE TREATMENT OF HEDGEHOG PATHWAY-RELATED DISORDERS
    Publication number: 20110183962
    Abstract: The invention provides methods for modulating, e.g., antagonizing, the activity of the Hedgehog signaling pathway, and for treating Hedgehog related disorders such as cancers (e.g., medulloblastoma). In particular, the invention provides methods for inhibiting aberrant growth states resulting from phenotypes such as Ptch loss-of-function, Hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function by administering to a mammal combinations of Smoothened inhibitors (e.g., a compound of Formula I, Formula II, or Formula III, or any of the compounds listed herein or incorporated by reference) and cholesterol biosynthesis pathway inhibitors (e.g., statins), Gli inhibitors, and/or Phosphatidylinositol 3-kinase (PI3K) inhibitors.
    Type: Application
    Filed: September 28, 2009
    Publication date: July 28, 2011
    Applicant: Novartis AG
    Inventors: Marion Dorsch, John E. Monahan, Michael Patrick Morrissey, Shifeng Pan, Juliet Williams
  • COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER
    Publication number: 20110092388
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
    Type: Application
    Filed: November 23, 2010
    Publication date: April 21, 2011
    Applicants: MILLENNIUM PHARMACEUTICALS, INC., Board of Regents, The University of Texas system
    Inventors: JAMES LILLIE, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch, Shubhangi Kamatkar, Maureen Mertens Hattersley, John E. Monahan, Vickesh Myer, Youzhen Wang, Yong Yao Xu, Xumei Zhao, Rachel E. Meyers, Robert C. Bast, JR., Gabriel N. Hortobagyi, Lajos Pusztai
  • Genes, compositions, kits, and methods for identification, assessment, prevention and therapy of cervical cancer
    Patent number: 7846737
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: December 7, 2010
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Robert Schlegel, Yan Chen, Xumei Zhao, John E. Monahan, Shubhangi Kamatkar, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch
  • NOVEL GENES, COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION AND THERAPY OF CERVICAL CANCER
    Publication number: 20100291616
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are provided.
    Type: Application
    Filed: June 14, 2010
    Publication date: November 18, 2010
    Applicant: MILLENNIUM PHARMACEUTICALS, INC.
    Inventors: Robert Schlegel, Yan Chen, Xumei Zhao, John E. Monahan, Shubhangi Kamatkar, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch
  • NUCLEIC ACID MOLECULES AND PROTEINS FOR THE IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF OVARIAN CANCER
    Publication number: 20100291068
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human ovarian cancers are provided.
    Type: Application
    Filed: March 8, 2010
    Publication date: November 18, 2010
    Applicants: MILLENNIUM PHARMACEUTICALS, INC., Board of Regents, The University of Texas System
    Inventors: Wilson O. Endege, Donna Ford, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch, Shubhangi Kamatkar, John E. Monahan, Robert Schlegel, Yong Yao Xu, Xumei Zhao, Robert C. Bast, JR., Gordon B. Mills, Karen Lu
  • Nucleic acid molecules and proteins for the identification, assessment, prevention, and therapy of ovarian cancer
    Patent number: 7799518
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with ovarian cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human ovarian cancers are provided.
    Type: Grant
    Filed: October 7, 2004
    Date of Patent: September 21, 2010
    Assignees: Millennium Pharmaceuticals, Inc., Board of Regents, University of Texas System
    Inventors: Wilson O. Endege, Donna Ford, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch, Shubhangi Kamatkar, John E. Monahan, Robert Schlegel, Yong Yao Xu, Xumei Zhao
  • COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER
    Publication number: 20100105051
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
    Type: Application
    Filed: September 25, 2009
    Publication date: April 29, 2010
    Applicants: MILLENNIUM PHARMACEUTICALS, INC., BOARD OF REGENTS, THE UNIVERSITY OF TEXAS
    Inventors: JAMES LILLIE, MANJULA GANNAVARAPU, KAREN GLATT, SEBASTIAN HOERSCH, SHUBHANGI KAMATKAR, MAUREEN MERTENS HATTERSLEY, JOHN E. MONAHAN, VICKESH MYER, YOUZHEN WANG, YONG YAO XU, XUMEI ZHAO, RACHEL E. MEYERS, ROBERT C. BAST, JR., GABRIEL N. HORTOBAGYI, LAJOS PUSZTAI
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
    Patent number: 7705120
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
    Type: Grant
    Filed: June 21, 2002
    Date of Patent: April 27, 2010
    Assignees: Millennium Pharmaceuticals, Inc., Board of Regents, University of Texas System
    Inventors: James Lillie, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch, Shubhangi Kamatkar, Maureen Mertens, Hattersley, John E. Monahan, Vickesh Myer, Youzhen Wang, Yongyao Xu, Xumei Zhao, Rachel E. Meyers, Robert C. Bast, Jr., Gabriel N. Hortobagyi, Lajos Pusztai
  • COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF BREAST CANCER
    Publication number: 20100075325
    Abstract: The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
    Type: Application
    Filed: September 11, 2009
    Publication date: March 25, 2010
    Applicants: MILLENNIUM PHARMACEUTICALS, INC., Board of Regents, The University of Texas System
    Inventors: John E. Monahan, Sebastian Hoersch, Dustin L. Anderson, Wilson O. Endege, Donna Ford, Karen Glatt, Bella O. Gorbatcheva, Shubhangi Kamatkar, Yong Yao Xu, Manjula Gannavarapu, Xumei Zhao, Robert Schlegel, Maureen Mertens Hattersley, Robert C. Bast, JR., Gabriel N. Hortobagyi, Lajos Pusztai
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
    Patent number: 7601505
    Abstract: The invention relates to nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: October 13, 2009
    Assignees: Millennium Pharmaceuticals, Inc., Board of Regents, The University of Texas Systems
    Inventors: John E. Monahan, Sebastian Hoersch, Dustin L. Anderson, Wilson O. Endege, Donna Ford, Karen Glatt, Bella O. Gorbatcheva, Shubhangi Kamatkar, Yong Yao Xu, Manjula Gannavarapu, Xumei Zhao, Robert Schlegel, Maureen Mertens, Robert C. Bast, Jr., Gabriel N. Hortobagyi, Lajos Pusztai
  • NOVEL GENES, COMPOSITIONS, KITS, AND METHODS FOR IDENTIFICATION, ASSESSMENT, PREVENTION, AND THERAPY OF COLON CANCER
    Publication number: 20090029365
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with colon cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human colon cancers are provided.
    Type: Application
    Filed: March 21, 2008
    Publication date: January 29, 2009
    Inventors: Allison Berger, Tracy L. Guillemette, Robert Schlegel, John E. Monahan, Shubhangi Kamatkar, Stephen N. Thibodeau, Lawrence J. Burgart
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer
    Publication number: 20080311573
    Abstract: The invention relates to newly discovered nucleic acid molecules and proteins associated with breast cancer. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human breast cancers are provided.
    Type: Application
    Filed: June 25, 2007
    Publication date: December 18, 2008
    Applicants: MILLENNIUM PHARMACEUTICALS, INC., Board of Regents, The University of Texas System
    Inventors: James Lillie, Manjula Gannavarapu, Karen Glatt, Sebastian Hoersch, Shubhangi Kamatkar, Maureen Mertens, John E. Monahan, Vickesh Myer, Youzhen Wang, Yongyao Xu, Xumei Zhao, Rachel E. Meyers, Robert C. Bast, JR., Gabriel N. Hortobagyi, Lajos Pusztai, Funda Meric, Aysegul Sahin, Gordon B. Mills
  • Compositions, kits, and methods for identification, assessment, prevention, and therapy of cervical cancer
    Publication number: 20080286781
    Abstract: The invention relates to nucleic acid molecules and proteins associated with cervical cancer including pre-malignant conditions such as dysplasia. Compositions, kits, and methods for detecting, characterizing, preventing, and treating human cervical cancers are also provided.
    Type: Application
    Filed: January 24, 2008
    Publication date: November 20, 2008
    Applicant: Millennium Pharmaceuticals, Inc.
    Inventors: John E. Monahan, Xumei Zhao, Yan Chen, Karen Glatt, Shubhangi Kamatkar