Abstract: A rotor assembly for a peristaltic pump is provided. Each of a first pair of roller assemblies includes a first roller portion having a first diameter and a second roller portion having a second diameter. The first diameter is larger than the second diameter. Each of a second pair of roller assemblies includes a first roller portion having a first diameter and a second roller portion having a second diameter. The first diameter is smaller than the second diameter. The first and second pairs of roller assemblies are positionable around a circumference of a hub such that the first roller portion of the first pair of roller assemblies is aligned with the first roller portion of the second pair of roller assemblies and the second roller portion of the first pair of roller assemblies is aligned with the second roller portion of the second pair of roller assemblies.

Abstract: The present invention relates to efficient synthetic processes useful in the preparation of antiviral nucleosides, particularly uridine 4-oxime 5?-(2-methylpropanoate) {(2R,3S,4R,5R)-3,4-dihydroxy-5-[4-(hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl]oxolan-2-yl}methyl 2-methylpropanoate and pharmaceutically acceptable salts, derivatives, tautomers, isomers, and prodrugs of, which may be active as antiviral agents, as well as compositions and methods thereof. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

Abstract: A filtration apparatus for use with drainage structures and a method for installing the same are provided. The filtration apparatus has a first grate and a second grate, which, when installed and secured together, establish a filtration barrier between the inlet and bottom of a drainage structure for filtering stormwater runoff entering the drainage structure. The first grate and second grate are secured to internal walls of the drainage structure via anchoring members. The anchoring members allow each of the grates to rotate to facilitate transition of each grate from a hanging to a suspended position. A connecting member secures the first grate and the second grate together so that the grates bisect the cavity of the drainage structure.

Abstract: This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin ? complexed with heparin and/or heparin-like structure (AT?H). These AT?H binding proteins can block the anti-coagulant activity of AT? to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

Abstract: Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

Abstract: Antibodies are disclosed that bind to and inhibit the anti-coagulant function of TFPI and have a lower affinity for TFPi at pH 6.0 than at pH 7.4. The lower affinity at pH 6 improves circulating half-life (T1/2) due to reduced target mediated clearance, a process by which an antibody/antigen complex, is endocytased and trafficked to the lysosome where both components are degraded. The lower affinity at pH 6.0 results in disruption of the complex prior to lysosome targeting and allows for re-circulation of the antibody. Specific modifications to antibody binding by histidine residue substitution are disclosed along with methods of use.

Abstract: A system and method for treating liquid runoff from bridge decks or other types of roadways are provided. The system includes vertical scuppers positioned at low points along a length of a bridge deck. Each scupper has a removable tube fitted inside the scupper with a filtration media for treating liquid runoff such as stormwater. During rainfall events, liquid runoff gravity flows downward through the tubes and the filtration media inside the tubes so that the liquid is treated before being discharged to the environment. The tubes can be removed to periodically replace the filtration media.

Abstract: This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin ? complexed with heparin and/or heparin-like structure (AT?H). These AT?H binding proteins can block the anti-coagulant activity of AT? to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

Abstract: A system and method for treating liquid runoff from bridge decks or other types of roadways are provided. The system includes vertical scuppers positioned at low points along a length of a bridge deck. Each scupper has a removable tube fitted inside the scupper with a filtration media for treating liquid runoff such as stormwater. During rainfall events, liquid runoff gravity flows downward through the tubes and the filtration media inside the tubes so that the liquid is treated before being discharged to the environment. The tubes can be removed to periodically replace the filtration media.

Abstract: This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin ? complexed with heparin and/or heparin-like structure (AT?H). These AT?H binding proteins can block the anti-coagulant activity of AT? to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

Abstract: Isolated monoclonal antibodies that bind human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided. Methods of producing the antibodies are also provided.

Abstract: A filtration apparatus for use with drainage structures and a method for installing the same are provided. The filtration apparatus has a first grate and a second grate, which, when installed and secured together, establish a filtration barrier between the inlet and bottom of a drainage structure for filtering stormwater runoff entering the drainage structure. The first grate and second grate are secured to internal walls of the drainage structure via anchoring members. The anchoring members allow each of the grates to rotate to facilitate transition of each grate from a hanging to a suspended position. A connecting member secures the first grate and the second grate together so that the grates bisect the cavity of the drainage structure.

Abstract: Isolated monoclonal antibodies that bind to specific epitopes of human tissue factor pathway inhibitor (TFPI) and the isolated nucleic acid molecules encoding them are provided. Pharmaceutical compositions comprising the anti-TFPI monoclonal antibodies and methods of treating deficiencies or defects in coagulation by administration of the antibodies are also provided.

Abstract: This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin ? complexed with heparin and/or heparin-like structure (AT?H). These AT?H binding proteins can block the anti-coagulant activity of AT? to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

Abstract: This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.

Abstract: This invention relates to Factor VIII muteins that are covalently bound, at a predefined site that is not an N-terminal amine, to one or more biocompatible polymers such as polyethylene glycol. The mutein conjugates retain FVIII procoagulant activity and have improved pharmacokinetic properties.

Abstract: This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin ? complexed with heparin and/or heparin-like structure (AT?H). These AT?H binding proteins can block the anti-coagulant activity of AT? to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.

Abstract: Provided herein are protein biomarkers for NETosis related diseases, including proteases. Also provided are substrate sequences of such proteases and uses thereof.

Abstract: Antibodies are disclosed that bind to and inhibit the anti-coagulant function of TFPI and have a lower affinity for TFPI at pH 6.0 than at pH 7.4. The lower affinity at pH 6 improves circulating half-life (T½) due to reduced target mediated clearance, a process by which an antibody/antigen complex is endocytosed and trafficked to the lysosome where both components are degraded. The lower affinity at pH 6.0 results in disruption of the complex prior to lysosome targeting and allows for re-circulation of the antibody. Specific modifications to antibody binding by histidine residue substitution are disclosed along with methods of use.