Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.

Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.

Abstract: The invention is composed of monoclonal human MN antibodies or MN antibody fragments that target the GEEDLP repeat within the proteoglycan domain. The proteoglycan domain of the MN cell surface protein contains four of these identical GEEDLP repeats. Binding to the desired epitope is verified by competition ELISA, where ELISA signal can be attenuated by co-incubation with a peptide containing this repeat (PGEEDLPGEEDLP). This inhibition of binding can also be verified using Biacore assays, where binding of desired antibodies to immobilized MN or proteoglycan peptides can be inhibited by the peptide repeat. In addition to binding to the peptide repeat, human anti-MN antibodies can inhibit the cell adhesion of CGL-1 cells to MN coated plastic plates. Human anti-MN antibodies have been used to diagnose and quantify MN expression in cancer cells and tumors using FACS and immunohistochemical methods.

Abstract: The present invention provides methods for modulating angiogenesis by administering anti-angiogenic FGF-19 polypeptides to a subject. Methods of modulating angiogenesis by administering an anti-angiogenic FGF-19 nucleic acid are also provided.

Abstract: This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.

Abstract: This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.

Abstract: In accordance with the present invention, there are provided lipid-conjugated polyamide compounds and related compositions and methods thereof. Lipid-conjugated polyamide compounds of the present invention are particularly useful as vehicles for delivering biologically active agents to a target site. In particular, the invention compounds are effective at facilitating the delivery of polynucleotides to cells. The present invention also provides a method for producing stable formulations of polynucleotides complexed with a delivery vehicle.

Abstract: Cells producing recombinant retroviral particles are provided. The cells contain a first vector having a coding region encoding retroviral LTRs and a packaging signal under the control of an expression control system, a tRNA binding site located upstream from the packaging signal and origin of second strand DNA synthesis located downstream from the packaging signal. The cells also contain a second vector having a coding region encoding retroviral capsid proteins gag and pol under the control of an expression control system and a third vector having a coding region encoding a simian type D retrovirus envelope glycoprotein under the control of an expression control system.

Abstract: An apparatus for the composting of fermentable organic refuse includes a rotating digester tube with a feed auger continuously providing refuse to the tube and a number of discharge outlets at the distal end of the tube. A number of agitating vanes extend along substantially the entire length of the interior of the digester tube, each vane including sections extending parallel to the axis of the tube and sections angled relative to the tube axis to assist in transporting the refuse along the tube. The digester tube is also provided with a number of air tubes extending along substantially the entire length of the tube and connected through a plenum to a blower at the distal end of the tube. Each of the air tubes includes a number of air openings therethrough for providing counter-flow air at each stage of the fermentation process within the tube.

Abstract: An apparatus for the composting of fermentable organic refuse includes a rotating digester tube with a feed auger continuously providing refuse to the tube and a number of discharge outlets at the distal end of the tube. A number of agitating vanes extend along substantially the entire length of the interior of the digester tube, each vane including sections extending parallel to the axis of the tube and sections angled relative to the tube axis to assist in transporting the refuse along the tube. The digester tube is also provided with a number of air tubes extending along substantially the entire length of the tube and connected through a plenum to a blower at the distal end of the tube. Each of the air tubes includes a number of air openings therethrough for providing counter-flow air at each stage of the fermentation process within the tube.

Abstract: A table carries guides for receiving and guiding a heat pipe. The heat pipe has a fill port which contains a valve. The heat pipe is thrust against the seal face of a block for evacuating and filling the fluid chamber of the heat pipe. A hex driver passes through the block and engages the valve to open and close the valve while the fill port is sealed from the atmosphere.

Abstract: A table carries guides for receiving and guiding a heat pipe. The heat pipe has a fill port which contains a valve. The heat pipe is thrust against the seal face of a block for evacuating and filling the fluid chamber of the heat pipe. A hex driver passes through the block and engages the valve to open and close the valve while the fill port is sealed from the atmosphere.

Abstract: A plurality of heat pipes extend longitudinally through a unitary or segmented circuit card module, terminating at both ends in cavities formed along lateral edges of the module. In one embodiment, bellows extend outwardly from the cavities in a direction normal to the plane of the module, terminating in interface plates which extends along the respective lateral edges of the module. In another embodiment, upstanding pillars are connected to bellows covering the cavities. Electronic components are mounted on a circuit card applied to a face of the module. The module is loosely received between opposed liquid cooled surfaces of guiderails in a circuit card rack. Heat from the components is communicated through the card to the heat pipes, increasing the pressure within the pipes to urge the interface plates or pillars into variable pressure contact with the guiderails. The pressure is sufficient to snugly hold the module in the rack.

Abstract: The present invention is concerned with the provision of an apparatus for the metering of a viscous fluid, and more particularly to a metering device for controlling the advance of margarine feedstock into a crystallization chamber for molding into print forms by employing a first and second positive open and closure valve mechanism correspondingly operated by independent drive mechanisms.