Patents by Inventor John E. Sims

John E. Sims has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies that inhibit TSLP activity
    Patent number: 9346870
    Abstract: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: May 24, 2016
    Assignee: IMMUNEX CORPORATION
    Inventors: John E. Sims, Stewart D. Lyman, Hilary J. McKenna, Allison P. Jacob
  • IL-1 FAMILY VARIANTS
    Publication number: 20160137708
    Abstract: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
    Type: Application
    Filed: January 22, 2016
    Publication date: May 19, 2016
    Applicant: Amgen Inc.
    Inventors: John E. Sims, Blair R. Renshaw, Christopher Gabel, Jennifer E. Towne, Randal R. Ketchum
  • Antibodies That Inhibit TSLP Activity
    Publication number: 20150005226
    Abstract: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Application
    Filed: September 16, 2014
    Publication date: January 1, 2015
    Inventors: John E. Sims, Stewart D. Lyman, Hilary J. McKenna, Allison P. Jacob
  • IL-1F8 polypeptides
    Patent number: 8871192
    Abstract: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
    Type: Grant
    Filed: June 11, 2013
    Date of Patent: October 28, 2014
    Assignee: Amgen Inc.
    Inventors: John E. Sims, Blair R. Renshaw, Christopher Gabel, Jennifer E. Towne, Randal R. Ketchem
  • Methods of treatment using IL-18 receptor antigen binding proteins
    Patent number: 8540993
    Abstract: Provided herein are IL-18 receptor antigen binding proteins and polynucleotides encoding the same. Expression vectors and host cells comprising the same for production of the antigen binding proteins are also provided. In addition, provided are compositions and methods for diagnosing and treating diseases mediated by IL-18 receptor.
    Type: Grant
    Filed: August 20, 2012
    Date of Patent: September 24, 2013
    Assignee: AMGEN Inc.
    Inventors: Dirk E. Smith, John E. Sims, Jeffrey T. McGrew, Marek Z. Kubin, Duncan Cochrane, Louise Conroy
  • IL-1F5 polypeptides
    Patent number: 8481021
    Abstract: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
    Type: Grant
    Filed: September 2, 2011
    Date of Patent: July 9, 2013
    Assignee: Amgen Inc.
    Inventors: John E Sims, Blair R Renshaw, Christopher Gabel, Jennifer E. Towne, Randal R Ketchem
  • Antibodies that inhibit TSLP activity
    Patent number: 8444979
    Abstract: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: September 23, 2011
    Date of Patent: May 21, 2013
    Assignee: Immunex Corporation
    Inventors: John E Sims, Stewart D Lyman, Hilary J McKenna, Allison P Armstrong
  • IL-18 RECEPTOR ANTIGEN BINDING PROTEINS
    Publication number: 20130034569
    Abstract: Provided herein are IL-18 receptor antigen binding proteins and polynucleotides encoding the same. Expression vectors and host cells comprising the same for production of the antigen binding proteins are also provided. In addition, provided are compositions and methods for diagnosing and treating diseases mediated by IL-18 receptor.
    Type: Application
    Filed: August 20, 2012
    Publication date: February 7, 2013
    Inventors: Dirk E. SMITH, John E. Sims, Jeffrey T. McGrew, Marek Z. Kubin, Duncan Cochrane, Louise Conroy
  • IL-18 receptor antigen binding proteins
    Patent number: 8257707
    Abstract: Provided herein are IL-18 receptor antigen binding proteins and polynucleotides encoding the same. Expression vectors and host cells comprising the same for production of the antigen binding proteins are also provided. In addition, provided are compositions and methods for diagnosing and treating diseases mediated by IL-18 receptor.
    Type: Grant
    Filed: July 24, 2008
    Date of Patent: September 4, 2012
    Assignee: Amgen Inc.
    Inventors: Dirk E. Smith, John E. Sims, Jeffrey T. McGrew, Marek Z. Kubin, Duncan Cochrane, Louise Conroy
  • IL-1 FAMILY VARIANTS
    Publication number: 20120020918
    Abstract: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
    Type: Application
    Filed: September 2, 2011
    Publication date: January 26, 2012
    Applicant: Amgen Inc.
    Inventors: John E. Sims, Blair R. Renshaw, Christopher Gabel, Jennifer E. Towne, Randal R. Ketchem
  • Host cells expressing IL-18 receptors
    Patent number: 8053233
    Abstract: A novel polypeptide that functions as an IL-18 receptor is disclosed. The receptor is multimeric and includes at least one AcPL polypeptide, or fragment thereof, and at least one IL-1Rrp1 polypeptide, or fraction thereof. The receptor binds IL-18 and finds use in inhibiting biological activities mediated by IL-18.
    Type: Grant
    Filed: March 3, 2010
    Date of Patent: November 8, 2011
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • IL-1F6 polypeptides
    Patent number: 8034771
    Abstract: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
    Type: Grant
    Filed: September 10, 2007
    Date of Patent: October 11, 2011
    Assignee: Amgen Inc.
    Inventors: John E. Sims, Blair R. Renshaw, Christopher Gabel, Jennifer E. Towne, Randal R. Ketchem
  • Methods of treating inflammatory disorders of the lungs
    Patent number: 8034343
    Abstract: 2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation.
    Type: Grant
    Filed: October 22, 2009
    Date of Patent: October 11, 2011
    Assignee: Immunex Corporation
    Inventors: Patricia Parnet, John E. Sims
  • ACPL-related assays
    Patent number: 7993845
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: October 12, 2010
    Date of Patent: August 9, 2011
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • IL-18 RECEPTOR ANTIGEN BINDING PROTEINS
    Publication number: 20110014201
    Abstract: Provided herein are IL-18 receptor antigen binding proteins and polynucleotides encoding the same. Expression vectors and host cells comprising the same for production of the antigen binding proteins are also provided. In addition, provided are compositions and methods for diagnosing and treating diseases mediated by IL-18 receptor.
    Type: Application
    Filed: July 24, 2008
    Publication date: January 20, 2011
    Applicant: AMGEN INC.
    Inventors: Dirk E. Smith, John E. Sims, Jeffrey T. McGrew, Marek Z. Kubin, Duncan Cochrane, Louise Conroy
  • ACPL-related assays
    Patent number: 7838248
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: September 17, 2007
    Date of Patent: November 23, 2010
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • Antibodies that inhibit TSLP activity
    Patent number: 7786271
    Abstract: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: July 28, 2008
    Date of Patent: August 31, 2010
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Stewart D. Lyman, Hilary J. McKenna, Allison P. Armstrong
  • IL-18 Receptors
    Publication number: 20100190211
    Abstract: A novel polypeptide that functions as an IL-18 receptor is disclosed. The receptor is multimeric and includes at least one AcPL polypeptide, or fragment thereof, and at least one IL-1Rrp1 polypeptide, or fraction thereof. The receptor binds IL-18 and finds use in inhibiting biological activities mediated by IL-18.
    Type: Application
    Filed: March 3, 2010
    Publication date: July 29, 2010
    Applicant: IMMUNEX CORPORATION
    Inventors: John E. Sims, Teresa L. Born
  • IL-18 receptors
    Patent number: 7704945
    Abstract: A novel polypeptide that functions as an IL-18 receptor is disclosed. The receptor is multimeric and includes at least one AcPL polypeptide, or fragment thereof, and at least one IL-1Rrp1 polypeptide, or fraction thereof. The receptor binds IL-18 and finds use in inhibiting biological activities mediated by IL-18.
    Type: Grant
    Filed: January 29, 2007
    Date of Patent: April 27, 2010
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • IL-1 ZETA, IL-1 ZETA SPLICE VARIANTS AND XREC2 DNAS AND POLYPEPTIDES
    Publication number: 20100047867
    Abstract: The invention is directed to novel, purified and isolated IL-1 zeta and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and uses thereof.
    Type: Application
    Filed: August 3, 2009
    Publication date: February 25, 2010
    Applicant: Immunex Corporation
    Inventors: John E. Sims, Dirk E. Smith, Teresa L. Born