Patents by Inventor John E. Sims

John E. Sims has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human IL-1 epsilon DNA and polypeptides
    Patent number: 7659375
    Abstract: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and immune reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, and kits comprising these reagents.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: February 9, 2010
    Assignee: Immunex Corporation
    Inventors: John E Sims, Dirk E Smith
  • Methods for determining 2F1-binding compounds
    Patent number: 7625710
    Abstract: 2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation.
    Type: Grant
    Filed: June 25, 2007
    Date of Patent: December 1, 2009
    Assignee: Immunex Corporation
    Inventors: Patricia Parnet, John E. Sims
  • IL-1 zeta splice variant polypeptide
    Patent number: 7585949
    Abstract: The invention is directed to novel, purified and isolated IL-1 zeta and Xrec2 polypeptides and fragments thereof, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and uses thereof.
    Type: Grant
    Filed: March 13, 2007
    Date of Patent: September 8, 2009
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Dirk E. Smith, Teresa L. Born
  • Methods for treating Disease with an IL-1R antibody
    Publication number: 20090022733
    Abstract: The invention pertains to methods for treating medical disorders characterized by elevated levels or abnormal expression of IL-1 by administering an IL-1 antagonist, such as soluble type II IL-1 receptor.
    Type: Application
    Filed: March 4, 2008
    Publication date: January 22, 2009
    Inventors: John E. Sims, Larry F. O'Neal
  • Antibodies that inhibit TSLP activity
    Publication number: 20090017034
    Abstract: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Application
    Filed: July 28, 2008
    Publication date: January 15, 2009
    Applicant: IMMUNEX Corporation
    Inventors: John E. Sims, Stewart D. Lyman, Hilary J. McKenna, Allison P. Armstrong
  • ACPL-related assays
    Publication number: 20090004674
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Application
    Filed: September 17, 2007
    Publication date: January 1, 2009
    Inventors: John E. Sims, Teresa L. Born
  • Human IL-1 epsilon DNA and polypeptides
    Publication number: 20080254025
    Abstract: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, the use of such polypeptides in cellular and immune reactions, the use of such polypeptides in screening for agonists or antagonists of IL-1 epsilon activity, and kits comprising such polypeptides.
    Type: Application
    Filed: July 17, 2007
    Publication date: October 16, 2008
    Applicant: Immunex Corporation
    Inventors: John E. Sims, Dirk E. Smith
  • IL-1 family variants
    Publication number: 20080241096
    Abstract: The present invention provides compositions and methods relating to IL-1Rrp2 requiring proteins.
    Type: Application
    Filed: September 10, 2007
    Publication date: October 2, 2008
    Applicant: Amgen Inc.
    Inventors: John E. Sims, Blair R. Renshaw, Christopher Gabel, Jennifer E. Towne, Randal R. Ketchem
  • Methods for treating IL-18 mediated disorders
    Publication number: 20080213257
    Abstract: The invention pertains to methods for treating medical disorders characterized by elevated levels or abnormal expression of IL-18 by administering an IL-18 antagonist, such as soluble IL-18 receptor, a soluble IL-18 binding protein and/or an antibody.
    Type: Application
    Filed: February 28, 2007
    Publication date: September 4, 2008
    Applicant: Immunex Corporation
    Inventors: John E. Sims, Kendal M. Mohler, Teresa L. Born
  • ANTIBODIES THAT BIND RECEPTOR PROTEIN DESIGNATED 2F1
    Publication number: 20080213793
    Abstract: 2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation.
    Type: Application
    Filed: June 25, 2007
    Publication date: September 4, 2008
    Applicant: Immunex Corporation
    Inventors: Patricia Parnet, John E. Sims
  • Human TSLP polynucleotides
    Patent number: 7405058
    Abstract: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: June 13, 2006
    Date of Patent: July 29, 2008
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Stewart D. Lyman, Hilary Jean McKenna, Allison P. Armstrong
  • Antibodies binding to human TSLP Polypeptides
    Patent number: 7304144
    Abstract: The invention is directed to purified and isolated novel TSLP polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: December 4, 2007
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Stewart D. Lyman, Hilary J. McKenna, Allison P. Armstrong
  • IL-1 receptor accessory protein
    Patent number: 7285634
    Abstract: DNA encoding IL-1R AcP splice variant polypeptides, the polypeptides and methods for using the encoded polypeptides are disclosed.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: October 23, 2007
    Assignee: Immunex Corporation
    Inventors: John E Sims, Dirk E Smith
  • IL-1 delta DNA and polypeptides
    Patent number: 7285648
    Abstract: DNA encoding IL-1 delta polypeptides and methods for using the DNA and encoded polypeptides are disclosed.
    Type: Grant
    Filed: July 10, 2000
    Date of Patent: October 23, 2007
    Assignee: Immunex Corporation
    Inventor: John E. Sims
  • ACPL antibodies and methods of use thereof
    Patent number: 7270817
    Abstract: The invention is directed to purified and isolated novel ACPL polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, and the uses of the above.
    Type: Grant
    Filed: February 6, 2004
    Date of Patent: September 18, 2007
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Teresa L. Born
  • Methods of treating inflammatory and/or autoimmune disease
    Patent number: 7261894
    Abstract: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, the use of such polypeptides in cellular and immune reactions, the use of such polypeptides in screening for agonists or antagonists of IL-1 epsilon activity, and kits comprising such polypeptides.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: August 28, 2007
    Assignee: Immunex Corporation
    Inventors: John E Sims, Dirk E Smith
  • Human IL-1 epsilon DNA and polypeptides
    Patent number: 7250276
    Abstract: The invention is directed to purified and isolated novel human IL-1 epsilon polypeptides, the nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, fragmented peptides derived from these polypeptides, the use of such polypeptides and fragmented peptides in cellular and immune reactions and as molecular weight markers, the use of such polypeptides and fragmented peptides as controls for peptide fragmentation, and kits comprising these reagents.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: July 31, 2007
    Assignee: Immunex Corporation
    Inventors: John E Sims, Dirk E Smith
  • IL-1 eta DNA and polypeptides
    Patent number: 7235637
    Abstract: The invention is directed to novel, purified and isolated IL-1 eta polypeptides and fragments thereof, the polynucleotides encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, peptides derived from these polypeptides, and uses thereof.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: June 26, 2007
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Blair R. Renshaw
  • Antibodies that bind receptor protein designated 2F1
    Patent number: 7235238
    Abstract: 2F1 polypeptides are provided, along with DNA sequences, expression vectors and transformed host cells useful in producing the polypeptides. Soluble 2F1 polypeptides find use in inhibiting prostaglandin synthesis and treating inflammation.
    Type: Grant
    Filed: May 28, 2004
    Date of Patent: June 26, 2007
    Assignee: Amgen Inc.
    Inventors: Patricia Parnet, John E. Sims
  • IL-1 eta DNA and polypeptides
    Patent number: 7223565
    Abstract: The invention is directed to novel, purified and isolated IL-1 eta polypeptides and fragments thereof, the polynucleotides encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against these polypeptides, peptides derived from these polypeptides, and uses thereof.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: May 29, 2007
    Assignee: Immunex Corporation
    Inventors: John E. Sims, Blair R. Renshaw