Patents by Inventor John F. Engelhardt

John F. Engelhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods to enhance rAAV transduction
    Patent number: 8846030
    Abstract: Agents and methods to alter rAAV transduction are provided.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: September 30, 2014
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Engelhardt, Dongsheng Duan
  • METHODS FOR CLONING FERRETS AND TRANSGENIC FERRET MODELS FOR DISEASES
    Publication number: 20110054247
    Abstract: The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserved Mustelidae embryos.
    Type: Application
    Filed: July 13, 2010
    Publication date: March 3, 2011
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: XINGSHEN SUN, YALING YI, GREGORY H. LENO, JOHN F. ENGELHARDT, ZIYING YAN, MICHAEL J. WELSH, CHRIS ROGERS, Xiaoming Liu
  • Adeno-associated virus vectors
    Patent number: 7803622
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Grant
    Filed: February 15, 2005
    Date of Patent: September 28, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Engelhardt, Dongsheng Duan
  • Compounds and methods to enhance rAAV transduction
    Patent number: 7749491
    Abstract: Agents and methods to alter rAAV transduction are provided.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: July 6, 2010
    Assignees: University of Iowa Research Foundation, Targeted Genetics Corporation
    Inventors: John F. Engelhardt, Keith L. Munson, Ziying Yan
  • Adeno-associated virus vectors
    Publication number: 20090265796
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Application
    Filed: August 7, 2007
    Publication date: October 22, 2009
    Inventors: John F. Engelhardt, Dongsheng Duan
  • Method of identifying compounds useful to treat neuronal degenerative diseases
    Publication number: 20090239243
    Abstract: Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided.
    Type: Application
    Filed: August 7, 2007
    Publication date: September 24, 2009
    Inventors: John F. Engelhardt, Weihong Zhou, Maged M. Harraz, Jennifer J. Marden
  • METHODS FOR CLONING FERRETS AND TRANSGENIC FERRET MODELS FOR DISEASES
    Publication number: 20090241206
    Abstract: The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserved Mustelidae embryos.
    Type: Application
    Filed: March 4, 2009
    Publication date: September 24, 2009
    Applicant: University of Iowa Research Foundation
    Inventors: Xingshen Sun, Yaling Yi, Gregory H. Leno, John F. Engelhardt, Ziying Yan, Michael J. Welsh, Chris Rogers
  • Methods and compounds to alter virus infection
    Publication number: 20090017062
    Abstract: The invention provides a method to identify an agent that alters parvovirus transduction of mammalian cells. Also provided is a method to enhance transgene expression in a mammalian cell, as well as a method to identify an agent that alters NADPH oxidase activity in parvovirus transduced mammalian cells.
    Type: Application
    Filed: April 27, 2007
    Publication date: January 15, 2009
    Applicant: Iowa Research Foundation Iowa Centers for Enterpri
    Inventors: John F. Engelhardt, Liang Zhang
  • Methods and compounds to alter virus infection
    Publication number: 20080261201
    Abstract: The invention provides a method to identify an agent that alters parvovirus transduction of mammalian cells. Also provided is a method to enhance transgene expression in a mammalian cell, as well as a method to identify an agent that alters NADPH oxidase activity in parvovirus transduced mammalian cells.
    Type: Application
    Filed: August 7, 2007
    Publication date: October 23, 2008
    Applicant: university of Iowa Research foundation iowa centers for enterprise
    Inventors: John F. Engelhardt, Liang Zhang
  • Compounds and methods to enhance rAAV transduction
    Publication number: 20080249050
    Abstract: Agents and methods to alter rAAV transduction are provided.
    Type: Application
    Filed: August 7, 2007
    Publication date: October 9, 2008
    Inventors: John F. Engelhardt, Keith L. Munson, Ziying Yan
  • Adeno-associated viruses and uses thereof
    Publication number: 20080226600
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Application
    Filed: August 7, 2007
    Publication date: September 18, 2008
    Inventors: John F. Engelhardt, Dongsheng Duan, Ziying Yan
  • Compounds and methods to enhance rAAV transduction
    Publication number: 20080213221
    Abstract: Agents and methods to alter rAAV transduction are provided.
    Type: Application
    Filed: August 7, 2007
    Publication date: September 4, 2008
    Inventors: John F. Engelhardt, Dongsheng Duan
  • Compounds and methods for pharmico-gene therapy of epithelial sodium channel associated disorders
    Publication number: 20080206198
    Abstract: Agents and methods to alter epithelial sodium channel (ENaC) activity.
    Type: Application
    Filed: August 7, 2007
    Publication date: August 28, 2008
    Inventors: John F. Engelhardt, Liang Zhang
  • Method of identifying compounds useful to treat neuronal degenerative diseases
    Publication number: 20080206792
    Abstract: Methods of identifying agents that inhibit ROS by altering the binding of a GTPase such as Rac to SOD, agents identified by the method, and methods of using compounds that inhibit ROS to inhibit or treat neuronal degenerative diseases, are provided.
    Type: Application
    Filed: August 7, 2007
    Publication date: August 28, 2008
    Inventors: John F. Engelhardt, Weihong Zhou, Maged M. Harraz, Jennifer J. Marden
  • Adeno-associated viruses and uses thereof
    Publication number: 20080166758
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Application
    Filed: June 21, 2007
    Publication date: July 10, 2008
    Inventors: John F. Engelhardt, Dongsheng Duan, Ziying Yan
  • Adeno-associated virus vectors and uses thereof
    Patent number: 7241447
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: July 10, 2007
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Engelhardt, Dongsheng Duan, Ziying Yan
  • Compounds and methods to enhance rAAV transduction
    Patent number: 7122335
    Abstract: Agents and methods to alter rAAV transduction, including agents and methods to enhance rAAV transduction, are provided. For instance, the invention provides methods to identify agents that enhance AAV transduction after viral binding to the cell membrane and before second strand synthesis.
    Type: Grant
    Filed: October 12, 2000
    Date of Patent: October 17, 2006
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Engelhardt, Dongsheng Duan
  • Adeno-associated virus vectors
    Patent number: 6897045
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: May 24, 2005
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Engelhardt, Dongsheng Duan
  • Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences
    Publication number: 20040248301
    Abstract: The invention provides recombinant AAV vectors, at least one of which has heterologous terminal palindromic sequences, and methods of using those vectors.
    Type: Application
    Filed: April 30, 2004
    Publication date: December 9, 2004
    Inventors: John F. Engelhardt, Ziying Yan
  • Transgenic animal model for spliceosome-mediated RNA trans-splicing
    Publication number: 20030204861
    Abstract: The present invention relates to development of an animal model system for in vivo testing of spliceosome-mediated RNA trans-splicing reactions. The present invention provides transgenic animals, and methods for generating such animals, that have been genetically engineered to expresses a target precursor messenger RNA molecule (target pre-mRNA) that serves as a substrate for a trans-splicing reaction. Specifically, the transgenic animals contain at least one transgene capable of expressing a target pre-mRNA molecule. The invention provides methods, based on utilization of the transgenic animals, for assessing the specificity and efficiency of a pre-trans-splicing molecule (PTM) designed to interact with a target pre-mRNA and mediate a trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule. The present invention further relates to the transgenic expression of PTM molecules in animals to determine gene function, i.e, functional genetics.
    Type: Application
    Filed: April 30, 2002
    Publication date: October 30, 2003
    Inventors: Madaiah Puttaraju, Lloyd G. Mitchell, John F. Engelhardt, Xiaoming Liu