Abstract: The disclosure relates in some aspects to methods of treating and diagnosing ?V?6 overexpressing cancer. In some embodiments, the disclosure relates to methods of treating and diagnosing ?V?6 and HER2 overexpressing cancer. In some embodiments, combination therapy strategies are employed.

Abstract: A lighted nock assembly is disclosed for use with an archery projectile. A cap fits within the tail end of the projectile shaft. The cap comprises a shoulder to bear against the projectile shaft, a recess terminating in a floor portion, and a face to bear against the shoulder of a nock. An LED/battery assembly fits within the recess of the cap abutting the floor portion. A nock fits over the LED/battery assembly and into the recess of the cap. Ready-to-fire, the LED/battery assembly comprises an activation gap between the LED lamp and the body of the battery assembly. A gap, greater than or equal to the activation gap, is left between the shoulder of the nock and the face of the cap. When fired, the bow string drives an internal surface of the nock into the front end of the LED/battery assembly and illuminates the LED lamp.

Abstract: A lighted nock assembly is disclosed for use with an archery projectile. A portion of an insert fits within, and is shouldered against, the tail end of the projectile shaft. The insert includes a recess terminating in a floor portion, and a face to bear against the nock shoulder. An LED/battery assembly fits within the recess of the insert abutting the floor portion. A nock fits over the LED/battery assembly and into the recess of the insert. Ready-to-fire, the LED/battery assembly comprises an activation gap between the LED lamp and the body of the battery assembly. A gap, greater than or equal to the activation gap, is left between the shoulder of the nock and the face of the insert. When fired, the bow string drives an internal surface of the nock into the front end of the LED/battery assembly and illuminates the LED lamp.

Abstract: A lighted nock assembly is disclosed for use with an archery projectile. A portion of an insert fits within, and is shouldered against, the tail end of the projectile shaft. The insert includes a recess terminating in a floor portion, and a face to bear against the nock shoulder. An LED/battery assembly fits within the recess of the insert abutting the floor portion. A nock fits over the LED/battery assembly and into the recess of the insert. Ready-to-fire, the LED/battery assembly comprises an activation gap between the LED lamp and the body of the battery assembly. A gap, greater than or equal to the activation gap, is left between the shoulder of the nock and the face of the insert. When fired, the bow string drives an internal surface of the nock into the front end of the LED/battery assembly and illuminates the LED lamp.

Abstract: The disclosure relates in some aspects to methods of treating and diagnosing ?V?6 overexpressing cancer. In some embodiments, the disclosure relates to methods of treating and diagnosing ?V?6 and HER2 overexpressing cancer. In some embodiments, combination therapy strategies are employed.

Abstract: A lighted nock assembly is disclosed for use with an archery projectile. A cap fits within the tail end of the projectile shaft. The cap comprises a shoulder to bear against the projectile shaft, a recess terminating in a floor portion, and a face to bear against the shoulder of a nock. An LED/battery assembly fits within the recess of the cap abutting the floor portion. A nock fits over the LED/battery assembly and into the recess of the cap. Ready-to-fire, the LED/battery assembly comprises an activation gap between the LED lamp and the body of the battery assembly. A gap, greater than or equal to the activation gap, is left between the shoulder of the nock and the face of the cap. When fired, the bow string drives an internal surface of the nock into the front end of the LED/battery assembly and illuminates the LED lamp.

Abstract: A lighted nock assembly is disclosed for use with an archery projectile. A cap fits within the tail end of the projectile shaft. The cap comprises a shoulder to bear against the projectile shaft, a recess terminating in a floor portion, and a face to bear against the shoulder of a nock. An LED/battery assembly fits within the recess of the cap abutting the floor portion. A nock fits over the LED/battery assembly and into the recess of the cap. Ready-to-fire, the LED/battery assembly comprises an activation gap between the LED lamp and the body of the battery assembly. A gap, greater than or equal to the activation gap, is left between the shoulder of the nock and the face of the cap. When fired, the bow string drives an internal surface of the nock into the front end of the LED/battery assembly and illuminates the LED lamp.

Abstract: A lighted nock assembly is disclosed for use with an archery projectile. A portion of an insert fits within, and is shouldered against, the tail end of the projectile shaft. The insert includes a recess terminating in a floor portion, and a face to bear against the nock shoulder. An LED/battery assembly fits within the recess of the insert abutting the floor portion. A nock fits over the LED/battery assembly and into the recess of the insert. Ready-to-fire, the LED/battery assembly comprises an activation gap between the LED lamp and the body of the battery assembly. A gap, greater than or equal to the activation gap, is left between the shoulder of the nock and the face of the insert. When fired, the bow string drives an internal surface of the nock into the front end of the LED/battery assembly and illuminates the LED lamp.

Abstract: A lighted nock assembly is disclosed for use with an archery projectile. A portion of an insert fits within, and is shouldered against, the tail end of the projectile shaft. The insert includes a recess terminating in a floor portion, and a face to bear against the nock shoulder. An LED/battery assembly fits within the recess of the insert abutting the floor portion. A nock fits over the LED/battery assembly and into the recess of the insert. Ready-to-fire, the LED/battery assembly comprises an activation gap between the LED lamp and the body of the battery assembly. A gap, greater than or equal to the activation gap, is left between the shoulder of the nock and the face of the insert. When fired, the bow string drives an internal surface of the nock into the front end of the LED/battery assembly and illuminates the LED lamp.

Abstract: The invention relates to materials and methods for modifying the binding of antibodies, and more particularly to antibodies that are obtainable by inserting an amino acid sequence capable of binding to a target into a complementarity determining region of a parent antibody so that the antibody thus obtained is capable of binding to the target. The invention further relates to the uses of the antibodies for therapy, diagnosis or imaging, and to methods of producing the antibodies.

Abstract: The present invention relates to antibodies that are obtained by inserting an amino acid sequence capable of binding to a target into the complementarity determining region (CDR) of a parent antibody. The antibody thus obtained has a new binding specificity. For example, the antibodies of the present invention are able to bind to the target, such as ?v?6 integrin, while retaining one or more of the useful properties of the parent antibody.

Abstract: A fletching system and method that allows for quick and easy attachment of a fletching member to an arrow or cross bolt shaft provides a slotted fletch holder adapted to receive a fletching member projecting therethrough and an external end cap member to provide frictional fit engagement with a flanged base portion of the fletching member wherein the flanged base portion is secured between the end cap member and an internal surface of a sidewall of the fletch holder.

Abstract: The present disclosure is directed to vanes and/or fletch members having a rearward, extended, flanged base portion for use in association with fletch holders and lighted nock assemblies such as are utilized with crossbow bolts, arrows, and the like. The rearward, extended, flanged base portion provides a floor against which a small-profile LED and battery assembly can bear during firing and subsequent LED activation.

Abstract: A lighted nock assembly is disclosed for use with an archery projectile. A cap fits within the tail end of the projectile shaft. The cap comprises a shoulder to bear against the projectile shaft, a recess terminating in a floor portion, and a face to bear against the shoulder of a nock. An LED/battery assembly fits within the recess of the cap abutting the floor portion. A nock fits over the LED/battery assembly and into the recess of the cap. Ready-to-fire, the LED/battery assembly comprises an activation gap between the LED lamp and the body of the battery assembly. A gap, greater than or equal to the activation gap, is left between the shoulder of the nock and the face of the cap. When fired, the bow string drives an internal surface of the nock into the front end of the LED/battery assembly and illuminates the LED lamp.

Abstract: A lighted nock assembly is disclosed for use with an archery projectile. A portion of an insert fits within, and is shouldered against, the tail end of the projectile shaft. The insert includes a recess terminating in a floor portion, and a face to bear against the nock shoulder. An LED/battery assembly fits within the recess of the insert abutting the floor portion. A nock fits over the LED/battery assembly and into the recess of the insert. Ready-to-fire, the LED/battery assembly comprises an activation gap between the LED lamp and the body of the battery assembly. A gap, greater than or equal to the activation gap, is left between the shoulder of the nock and the face of the insert. When fired, the bow string drives an internal surface of the nock into the front end of the LED/battery assembly and illuminates the LED lamp.

Abstract: A fletching system and method that allows for quick and easy attachment of a fletching member to an arrow or cross bolt shaft provides a slotted fletch holder adapted to receive a fletching member projecting therethrough and an external end cap member to provide frictional fit engagement with a flanged base portion of the fletching member wherein the flanged base portion is secured between the end cap member and an internal surface of a sidewall of the fletch holder.

Abstract: A fletching system and method that allows for quick and easy attachment of a fletching member to an arrow or cross bolt shaft provides a slotted fletch holder adapted to receive a fletching member projecting therethrough and an external end cap member to provide frictional fit engagement with a flanged base portion of the fletching member wherein the flanged base portion is secured between the end cap member and an internal surface of a sidewall of the fletch holder.

Abstract: A fletching system and method that allows for quick and easy attachment of a fletching member to an arrow or cross bolt shaft provides a slotted fletch holder adapted to receive a fletching member projecting therethrough and an external end cap member to provide frictional fit engagement with a flanged base portion of the fletching member wherein the flanged base portion is secured between the end cap member and an internal surface of a sidewall of the fletch holder.