Patents by Inventor John Flanagan

John Flanagan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12208095
    Abstract: The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2? breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: January 28, 2025
    Assignee: Arvinas Operations, Inc.
    Inventors: Andrew P. Crew, John Flanagan, Sheryl Maxine Gough, Royal J. Haskell, III, Marcia Dougan Moore, Yimin Qian, Ian Charles Anthony Taylor, Jing Wang
  • Patent number: 12194569
    Abstract: A system includes a robotic arm, a rotisserie control linkage, and a computer system. The robotic arm includes a touch probe and laser head. The rotisserie control linkage is configured to couple to a transport cart. The computer system is communicatively coupled to the robotic arm and the rotisserie control linkage and is configured to control the system to probe, using the touch probe of the robotic arm, a transparent outer layer of an aircraft canopy located on the transport cart in order to determine surface measurements of the aircraft canopy. The computer system also controls the system to ablate, using a plurality of predetermined parameters and the laser head of the robotic arm, an interface layer located between the transparent outer layer and the aircraft canopy, wherein movements of the robotic arm during the ablation are based on the surface measurements.
    Type: Grant
    Filed: August 10, 2021
    Date of Patent: January 14, 2025
    Assignee: Lockheed Martin Corporation
    Inventors: Jeffrey P. Langevin, Jeffrey T. Drewett, David Haynes Coleman, Daniel John Flanagan, Steven E. Twaddle
  • Patent number: 12188931
    Abstract: The present invention relates to an immunoassay for the detection of Borrelia specific IgG, IgM and IgG/IgM antibodies in biological samples suspected of Lyme infection. The immunoassay can be performed via a standard immunoassay format or on an automated platform. In various embodiments, the immunoassay uses one or more Borrelia specific chimeric peptides VlsE-FlaB (designated pFlaB-mV), VlsE-ErpP (designated pErp59-mV), VlsE-P35 (designated pP35-mV) alone or in combination with one or more outer surface protein C (Osp C) types B or I, p58 and DbpA. Other aspects of the invention provide antigen/substrate combinations and compositions comprising combinations of the disclosed peptides and/or proteins for use in the immunoassays described herein.
    Type: Grant
    Filed: December 27, 2021
    Date of Patent: January 7, 2025
    Assignee: BIO-RAD LABORATORIES, INC.
    Inventors: Michelle Delanoy, John Flanagan, Audrey Arjomandi, Ravi Kaul, Steven R. Binder
  • Publication number: 20240428400
    Abstract: Systems, components, methods, and algorithms for generating template information are described. a computer-implemented method includes receiving microscope image data, detecting a feature in the microscope image data, receiving feature template data describing a grouping of features including the feature, detecting the grouping in the microscope image data based at least in part on the feature template data, generating template information describing the grouping, and outputting the template information.
    Type: Application
    Filed: June 26, 2023
    Publication date: December 26, 2024
    Inventors: John Flanagan, Hayley Johanesen, Lucas Paul Winiarski, Christopher Hakala
  • Publication number: 20240354924
    Abstract: Disclosed herein are scientific instrument support systems, as well as related methods, computing devices, and computer-readable media. For example, in some embodiments, a scientific instrument support apparatus may include: first logic to receive, from a charged particle microscope, a microscopy image of a sample; second logic to generate a first processed image by processing the microscopy image through a general machine-learning model trained using a plurality of previously processed microscopy images; third logic to retrain the general machine-learning model with a related microscopy image, wherein the related microscopy image includes a label of an object related to the sample and the related microscopy image is not included in the plurality of previously processed microscopy images; and fourth logic to generate a second processed image, different from the first processed image, by processing the microscopy image through the retrained general machine-learning model.
    Type: Application
    Filed: April 19, 2023
    Publication date: October 24, 2024
    Inventors: John Flanagan, Andrei Novikov
  • Patent number: 11953438
    Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.
    Type: Grant
    Filed: June 17, 2022
    Date of Patent: April 9, 2024
    Assignee: STRECK LLC
    Inventors: Matthew R. Kreifels, Scott E. Whitney, Gregg Wilder, John Flanagan, James Dowling, Philip Hills, Michael Tilleman, Jeremie Jackson
  • Publication number: 20240094223
    Abstract: The invention provides a method of diagnosing Non-Alcoholic Steatohepatitis (NASH) and/or the hepatic fibrosis status of a subject, especially a subject afflicted with Non-alcoholic fatty liver disease (NAFLD) or NASH, based on the level of only three or more particular biomarkers. The invention further provides a kit suitable for performing said method and the use of said method and methods of treating patients diagnosed in accordance with the disclosed methods.
    Type: Application
    Filed: November 6, 2023
    Publication date: March 21, 2024
    Inventors: ISABELLE BATXELLI-MOLINA, FLORIAN SALIPANTE, ROGER P. WALKER, JOHN FLANAGAN, JEANNETTE FAREH-MICHIEL
  • Patent number: 11808772
    Abstract: The invention provides a method of diagnosing Non-Alcoholic Steatohepatitis (NASH) and/or the hepatic fibrosis status of a subject, especially a subject afflicted with Non-alcoholic fatty liver disease (NAFLD) or NASH, based on the level of only three or more particular biomarkers. The invention further provides a kit suitable for performing said method and the use of said method and methods of treating patients diagnosed in accordance with the disclosed methods.
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: November 7, 2023
    Inventors: Isabelle Batxelli-Molina, Florian Salipante, Roger P. Walker, John Flanagan, Jeannette Fareh-Michiel
  • Publication number: 20230245334
    Abstract: Methods include acquiring a series of images or spectra of a volume of a model sample, reconstructing a 3D image of the volume of the model sample using the series of images, constructing a 3D model of the volume of the model sample by forming a segmentation of the reconstructed 3D image and fitting one or more primitive geometrical shapes to the segmentation, acquiring test sample images or spectra, and measuring test sample critical dimensions using the constructed 3D model to guide analysis of test spectra or images. Additional methods and related systems are disclosed, optical critical dimension (OCD) methods and systems.
    Type: Application
    Filed: February 2, 2022
    Publication date: August 3, 2023
    Applicant: FEI Company
    Inventors: John Flanagan, Mary Wu, Erik Franken, Daniel Lichau
  • Publication number: 20230047797
    Abstract: A system includes a robotic arm, a rotisserie control linkage, and a computer system. The robotic arm includes a touch probe and laser head. The rotisserie control linkage is configured to couple to a transport cart. The computer system is communicatively coupled to the robotic arm and the rotisserie control linkage and is configured to control the system to probe, using the touch probe of the robotic arm, a transparent outer layer of an aircraft canopy located on the transport cart in order to determine surface measurements of the aircraft canopy. The computer system also controls the system to ablate, using a plurality of predetermined parameters and the laser head of the robotic arm, an interface layer located between the transparent outer layer and the aircraft canopy, wherein movements of the robotic arm during the ablation are based on the surface measurements.
    Type: Application
    Filed: August 10, 2021
    Publication date: February 16, 2023
    Inventors: Jeffrey P. Langevin, Jeffrey T. Drewett, David Haynes Coleman, Daniel John Flanagan, Steven E. Twaddle
  • Publication number: 20230034667
    Abstract: Methods and systems for implementing artificial intelligence enabled metrology are disclosed. An example method includes segmenting a first image of structure into one or more classes to form an at least partially segmented image, associating at least one class of the at least partially segmented image with a second image, and performing metrology on the second image based on the association with at least one class of the at least partially segmented image.
    Type: Application
    Filed: October 13, 2022
    Publication date: February 2, 2023
    Inventors: John FLANAGAN, Brad LARSON, Thomas MILLER
  • Patent number: 11569056
    Abstract: Methods and apparatuses are disclosed herein for parameter estimation for metrology. An example method at least includes optimizing, using a parameter estimation network, a parameter set to fit a feature in an image based on one or more models of the feature, the parameter set defining the one or more models, and providing metrology data of the feature in the image based on the optimized parameter set.
    Type: Grant
    Filed: October 29, 2019
    Date of Patent: January 31, 2023
    Assignee: FEI Company
    Inventors: Brad Larson, John Flanagan, Maurice Peemen
  • Patent number: 11563588
    Abstract: A path is secured from one node to another node of the computing environment. The one node obtains a first encryption key and a second encryption key. A shared key is obtained by the one node from a key server, and the shared key is used to encrypt a message. The encrypted message includes the first encryption key and the second encryption key. The encrypted message and an identifier of the shared key is sent from the one node to the other node, and a response message is received by the one node. The response message at least provides an indication that the other node received the encrypted message and obtained the shared key.
    Type: Grant
    Filed: May 10, 2021
    Date of Patent: January 24, 2023
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Patricia G. Driever, Roger G. Hathorn, Christopher Colonna, John Flanagan, George P. Kuch, Richard M. Sczepczenski, Glen Jaquette
  • Publication number: 20230020742
    Abstract: Systems and methods for automated sample alignment for microscopy are described herein.
    Type: Application
    Filed: July 6, 2022
    Publication date: January 19, 2023
    Inventors: John FLANAGAN, Michael STRAUSS
  • Patent number: 11522681
    Abstract: A path for a node of a computing environment is secured. The securing includes obtaining, by the node, a message that includes an identifier of a shared key and an encrypted message. The node obtains the shared key from a key server and uses it to decrypt the encrypted message to obtain an encryption key and one or more parameters. A security parameters index to be associated with the encryption key and the one or more parameters is obtained. The node sends a response message to another node, the response message including the security parameters index.
    Type: Grant
    Filed: December 30, 2020
    Date of Patent: December 6, 2022
    Assignee: INTERNATIONAL BUSINESS MACHINES CORPORATION
    Inventors: Patricia G. Driever, Roger G. Hathorn, Christopher Colonna, John Flanagan, George P. Kuch, Richard M. Sczepczenski, Glen Jaquette
  • Publication number: 20220347272
    Abstract: The present application provides for compositions comprising high concentrations of acid ?-glucosidase in combination with an active site-specific chaperone for the acid ?-glucosidase, and methods for treating Pompe disease in a subject in need thereof, that includes a method of administering to the subject such compositions. The present application also provides methods for increasing the in vitro and in vivo stability of an acid ?-glucosidase enzyme formulation.
    Type: Application
    Filed: March 21, 2022
    Publication date: November 3, 2022
    Inventors: Kenneth Valenzano, John Crowley, Richie Khanna, John Flanagan
  • Publication number: 20220326157
    Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.
    Type: Application
    Filed: June 17, 2022
    Publication date: October 13, 2022
    Inventors: Matthew R. Kreifels, Scott E. Whitney, Gregg Wilder, John Flanagan, James Dowling, Philip Hills, Michael Tilleman, Jeremie Jackson
  • Patent number: 11385178
    Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.
    Type: Grant
    Filed: June 25, 2018
    Date of Patent: July 12, 2022
    Assignee: STRECK, INC.
    Inventors: Matthew R. Kreifels, Scott E. Whitney, Gregg Wilder, John Flanagan, James Dowling, Philip Hills, Michael Tilleman, Jeremie Jackson
  • Publication number: 20220193072
    Abstract: The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2? breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.
    Type: Application
    Filed: December 13, 2021
    Publication date: June 23, 2022
    Inventors: Xin CHEN, Andrew P. CREW, John FLANAGAN, Sheryl Maxine GOUGH, Royal J. HASKELL, III, Marcia Dougan MOORE, Yimin QIAN, Ian Charles Anthony TAYLOR, Jing WANG
  • Publication number: 20220198075
    Abstract: A storage port receives a login request. The storage port configures an audit mode indicator as enabled in a login response to a host port to enter a security enabled mode to indicate to the host port that Input/Output (I/O) operations are to be transmitted from the host port to the storage port even if authentication or security association negotiation with the storage port cannot be completed successfully.
    Type: Application
    Filed: March 7, 2022
    Publication date: June 23, 2022
    Inventors: Roger G. Hathorn, Patricia G. Driever, John Flanagan, Christopher J. Colonna, Evan Rivera