Abstract: The disclosure is directed, in part, to improved systems and nucleic acids for modifying target DNA.

Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation of a tissue that include applying energy (e.g., ultrasound energy) into the tissue at multiple regions of interest, concurrently or consecutively. The neuromodulation may result in tissue displacement, which may be observed through changes in one or more molecules of interest.

Abstract: Disclosed is a woven product adapted to be used as a primary backing layer for a surface, ground or floor covering comprising artificial or synthetic grass or turf. The woven product comprises at least a first woven layer and a second woven layer, wherein the first and second woven layers are interwoven, the first woven layer comprises a plurality of warp tapes/threads and a plurality of weft tapes/threads, the warp tapes/threads and the weft tapes/threads of the first woven layer being substantially perpendicular to one another. The second woven layer comprises a plurality of warp tapes/threads and a plurality of weft tapes/threads, the warp tapes/threads and the weft tapes/threads of the second woven layer being substantially perpendicular to one another.

Abstract: The present invention provides novel methods of using nitric oxide donor compounds for treating infectious diseases, for example, COVID-19.

Abstract: An exemplary method comprises receiving information associated with a game-playing transaction conducted between a user device and a game-playing terminal, wherein the game-playing transaction is associated with a request for playing a game; determining a location of the user device associated with the game; determining the user device is located in an approved location associated with the game; and processing the game-playing transaction based on determining the user device is located in the approved location associated with the game. The game-playing transaction is conducted on a first communication interface, and the information associated with the game-playing transaction is received on a first or second communication interface.

Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.

Abstract: Systems and methods are provided for determining an optical bypass for an inter-regional wide area network (WAN) for regions of server facilities of a cloud service provider. In particular, the optical bypass connects non-adjacent regional server centers of the WAN by eliminating needs of data conversions at intermediate regional server centers. The determining the optical bypass includes receiving a WAN topology data, capacity and demand information about the WAN. The determining includes an objective function to maximize a number of network resources to free up by determining a revised data flow and bandwidth allocations by introducing the optical bypass in the WAN. The disclosed technology transmits the determined data traffic flow and resource allocation information of the optical bypass, causing a network traffic enforcers to reconfigure the WAN.

Abstract: Cleavable nucleotide analogs are provided. The nucleotide analog includes a nucleotide molecule attached to a cleavable moiety wherein the cleavable moiety comprises a protective group and/or a linker attached to a fluorophore. The cleavable moiety is linked to the oxygen atom of the 3?-OH of the pentose of the nucleotide molecule. The nucleotide analogs can be used in making polynucleotide molecules using template independent polymerases. The nucleotide analogs can act as reversible terminators during DNA sequencing by synthesis. The cleavage of the cleavable moiety restores a free 3?-OH functional group allowing growth of the polynucleotide molecule. The general structures as well as proposed synthetic schemes for the nucleotide analogs are also provided.

Abstract: A method for reducing slack in a linkage chain of a vehicle truck assembly is provided. In one example, the method includes responding to a request to de-lift a lift mechanism by reducing pressure in an actuator coupled to the lift mechanism, where the lift mechanism is configured to transfer a load from a first axle to a second axle of the vehicle during the de-lift, and during the de-lift, maintaining the pressure in the actuator at or above a threshold pressure to maintain tension in a weight transfer device of the lift mechanism.

Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

Abstract: The invention provides sample cartridges for processing samples. The sample cartridges comprise at least one fluidic channel. Each fluidic channel comprises a sample chamber, a lysis chamber, a binding chamber, a pre-amplification region, and an amplification region. The sample cartridges also comprise a waste line that is in fluidic connectivity with each fluidic channel. The sample cartridges can interface with a plurality of plungers that are capable of occluding at least one fluidic channel, waste line, and/or optional assay line to limit the transport of fluids into, out of, and/or along at least one fluidic channel by plunging. The invention also provides multi-channel sample cartridges, which are sample cartridges that comprise at least two fluidic channels. In addition, the sample cartridges can house fluids on the cartridge, off the cartridge, or some on the cartridge and some fluids off the cartridge.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: A cart includes a platform and a plurality of wheels supporting the platform. A plurality of retractable shelves are supported on the platform. The plurality of retractable shelves are reconfigurable between a deployed position and a retracted position. In the deployed position, a plurality of totes (or other smaller objects) can be supported on the shelves. In the retracted position, the cart is in an L Cart configuration. The platform is uncovered by the shelves and a larger item (or several larger items) can be placed on the platform.

Abstract: The present invention relates to an improved ball tossing device that is portable and adjustable to accommodate a variety of different balls and lobbing preferences. This may be achieved through various features including some or all of the following: a ball feeding mechanism using a rotating disk with an offset feed channel to deliver balls to the ball tossing queue; a catapult arm that uses a motor/spring mechanism to toss balls in the queue out of the machine; an indexer feature for isolating the ball to be tossed from the other balls in the queue; and adjustable features that allow users to vary ball trajectory of the ball being tossed.

Abstract: Systems and methods are provided for determining levels of an analyte in a biological fluid sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological fluid sample; a sensing element comprising at least two sensing electrodes, and at least one layer of a cofactor covering the sensing element in which the cofactor catalyzes a reaction to determine levels of an analyte in the biological fluid sample. The at least one disruptor of the transdermal sampling and analysis device may generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism. The surface of at least one of the sensing electrodes of the transdermal sampling and analysis device may be coated with a sensing layer in which an enzyme immobilized within a hydrogel.

Abstract: The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.

Abstract: An example peripheral device includes circuitry to identify a target device that matches the device type identifier of the peripheral device. The example circuitry of the peripheral device is to cause selection of an input component device, transmission of a request to place the input component of the target device into an instruction set receiver mode, and operation of an output component of the peripheral device to produce audio output or video output that represents the instruction set in response to a determination that an instruction set version identifier of the target device mismatches the instruction set version identifier of the peripheral device.

Abstract: Systems and methods are provided for determining levels of an analyte in a biological fluid sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological fluid sample; a sensing element comprising at least two sensing electrodes, and at least one layer of a cofactor covering the sensing element in which the cofactor catalyzes a reaction to determine levels of an analyte in the biological fluid sample. The at least one disruptor of the transdermal sampling and analysis device may generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism. The surface of at least one of the sensing electrodes of the transdermal sampling and analysis device may be coated with a sensing layer in which an enzyme immobilized within a hydrogel.

Abstract: A decumulation management system provides guidance for decumulation of a portfolio over a decumulation period of time. A spending amount is withdrawn from the portfolio during the decumulation period of time. The decumulation management system determines the probability of successfully withdrawing the spending amount during the remaining decumulation period and establishes thresholds for adjusting the spending amount and a risk profile of the portfolio based on the performance of the portfolio during the decumulation. When the portfolio value decreases below the thresholds, the spending amount may be reduced, and when the portfolio value exceeds the thresholds, the spending amount may be increased and the risk profile of the portfolio is decreased. The decumulation management system may provide recommendations based on these thresholds, or may automatically manage withdrawals of the spending amount and investments to match the risk profile.

Abstract: Multi-component fibers or filaments that are ribbon shaped are provided having polymer components positioned in a side-by-side fashion. For example, the multi-component fibers may be bicomponent fibers having ribbon shape. The polymer components of the fibers are selected to have differential shrinkage behavior. Nonwovens are also provided that are manufactured from such ribbon shaped multi-component fibers or filaments.