Abstract: In a preferred embodiment, there is provided a protecting group for protecting the thiol side chain of a cysteine residue, the protecting group comprising a Diels-Alder cycloadduct of a furan and a maleimide, and optionally, a linker interposed between the thiol side chain and the Diels-Alder cycloadduct.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for dynamically injecting secrets in a pipeline integration system. One of the methods includes receiving, by a pipeline controller, a job identifying a pipeline for executing a plurality of tasks. A preparatory task is invoked for the pipeline that obtains one or more original task definitions for the identified pipeline and generates one or more modified task definitions for the pipeline, wherein each modified task definition references one or more variablized secret names specified as the value of the reserved variable of the one or more configuration files. One or more subsequent execution tasks are invoked using each respective modified task definition. One or more retrieved secrets are injected into an execution environment for each particular execution task.

Abstract: Systems and methods are provided for determining levels of a target analyte in a biological sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological sample, at least two electrodes, and an electrochemical bioassay configured to determine levels of a target analyte in the biological sample. The at least one disruptor of the transdermal sampling and analysis device may be configured to generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism.

Abstract: The present invention provides novel compounds and pharmaceutical compositions thereof and methods of using the same for treating cardiovascular diseases.

Abstract: An example system includes an input engine to determine an aspect ratio of each of a plurality of video signals input to the system. The system includes an arrangement engine to determine positions in a display area for the plurality of video signals based on the aspect ratio of each video signal. The system includes a display engine to output screen content corresponding to the plurality of video signals at the determined positions.

Abstract: Methods and systems for manufacturing a transdermal sampling and analysis device for non-invasively and transdermally obtaining biological samples from a subject and determining levels of analytes of the obtained biological samples are provided. A method of manufacturing the device may improve performance and includes forming channel structures on the lid of the device, thereby making the spacer/channel support structures physically independent and separable from the sensing electrode. Other methods of manufacturing the device may improve performance and include forming at least one of the electrodes on each of the base and the lid, and forming a recessed second spacer layer over the channel support structures, thereby separating the channel support structures and the electrode on the lid to allow a larger area of the electrode to be exposed to the biological sample.

Abstract: A computer-implemented method is disclosed. The method includes: receiving, from a web server associated with a protected resource, a first signal including a request to validate a bearer token submitted by a client device to the web server, the bearer token including a digital signature; validating the bearer token, the validating including verifying the digital signature using a public key associated with an end user of the client device; and in response to validating the bearer token, sending to the web server a second signal including a notification that the bearer token is valid.

Abstract: Apparatus comprising: a sleeve adapted to be slid over the exterior of an endoscope; a proximal balloon secured to the sleeve; an inflation/deflation tube carried by the sleeve and in fluid communication with the interior of the proximal balloon; a push tube slidably mounted to the sleeve; and a distal balloon secured to the distal end of the push tube, the interior of the distal balloon being in fluid communication with the push tube, wherein the distal balloon is capable of assuming a deflated condition and an inflated condition, and further wherein when the distal balloon is in its deflated condition, an axial opening extends therethrough, the axial opening being sized to receive the endoscope therein, and when the distal balloon is in its inflated condition, the axial opening is closed down.

Abstract: An electronic device is disclosed. The electronic device includes a memory, a camera module, a communications module, and a processor that is configured to: receive first credentials identifying a user; transmit, via the communications module to an authentication server, a first signal including a request to verify that the first credentials are authorized for accessing a protected resource; when the first credentials are authorized for accessing the protected resource, receive, via the communications module from the authentication server, a second signal including an access token for use in authenticating the user on requests to access the protected resource; receive, from the camera module, image data associated with a machine-readable optical label, the optical label encoding transaction details of a first transaction; and generate a request based on the transaction details to access the protected resource for initiating the first transaction, the request including the access token.

Abstract: A method of separating a glass web includes the steps of placing the glass web in tension by applying an in-plane tension to the glass web in a tensile direction and producing a region of increased tension on a first major surface of the glass web by imparting a curvature in the glass web. The method further includes separating the glass web along a separation path parallel to an axis of the curvature and transverse to the tensile direction by applying a defect to a portion of the first major surface in the region of increased tension.

Abstract: The Reflected Light Collector System allows for the use of various types of lighting technologies to be used in a way that produces intense single point source light that can be controlled thru lenses like used in extremely bright projectors, concert moving head lights, theater&concert follow spots and TV/Film spot/wash lighting. Since the Reflected Light Collector System can use multiple efficient LEDs of various colors, this high intensity cumulative point light source can color mix those LEDs output when correctly controlled without the necessity of mechanically inserted color chips, color wheels or color gels like in other projected white light output fixtures thus eliminating the need for additional mechanical mechanisms in the fixture that can fail like as in ARC lamp type fixture or LED fixture with just a high intensity white light from one bulb, LED or lamp.

Abstract: A method for reducing slack in a linkage chain of a vehicle truck assembly is provided.

Abstract: Systems and methods are provided for determining levels of an analyte in a biological fluid sample. A transdermal sampling and analysis device may include a substrate, at least one disruptor mounted on the substrate, a reservoir configured to collect and contain a biological fluid sample; a sensing element comprising at least two sensing electrodes, and at least one layer of a cofactor covering the sensing element in which the cofactor catalyzes a reaction to determine levels of an analyte in the biological fluid sample. The at least one disruptor of the transdermal sampling and analysis device may generate a localized heat capable of altering permeability characteristics of a stratum corneum layer of skin of an organism. The surface of at least one of the sensing electrodes of the transdermal sampling and analysis device may be coated with a sensing layer in which an enzyme immobilized within a hydrogel.

Abstract: A metal matrix composite comprises and/or consists of a uniform distribution of calcined ceramic particles having an average particle size of between 0.30 and 0.900 microns and a metal or alloy uniformly distributed with the ceramic particles and wherein the ceramic particles include oxides of two separate metals selected from the group consisting of Al, Li, Be, Pb, Fe, Ag, Au, Sn, Mg, Ti, Cu, and Zn, and in which said ceramic particles comprise at least 15 volume percent of the metal matrix sintered together and wherein said metal-matrix being machinable with a high speed steel (HSS) bit for greater than about one minute without excessive wear to the bit.

Abstract: Apparatus includes treatment chamber including at least one outlet for exit of electrochemically treated liquid, and a liquid disperser having a plurality of liquid passageways, wherein each said liquid passageway includes at least one inlet to the treatment chamber for entry of a liquid to be treated; and a plurality of electrodes positioned within the treatment chamber for electrochemical treatment of the liquid.

Abstract: A method for regulating access to a protected resource is disclosed.

Abstract: Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

Abstract: Disclosed is a woven product adapted to be used as a primary backing layer for a surface, ground or floor covering comprising artificial or synthetic grass or turf. The woven product comprises at least a first woven layer and a second woven layer, wherein the first and second woven layers are interwoven, the first woven layer comprises a plurality of warp tapes/threads and a plurality of weft tapes/threads, the warp tapes/threads and the weft tapes/threads of the first woven layer being substantially perpendicular to one another. The second woven layer comprises a plurality of warp tapes/threads and a plurality of weft tapes/threads, the warp tapes/threads and the weft tapes/threads of the second woven layer being substantially perpendicular to one another.

Abstract: Embodiments of the present disclosure are directed to coated glass articles which reduce glass particle formation caused by glass to glass contact in pharmaceutical glass filling lines.

Abstract: A method for making a polynucleotide is provided including (a) delivering one or more reaction reagents including an error prone or template independent DNA polymerase, cations and a selected nucleotide to a reaction site including an initiator sequence having a terminal nucleotide for a time period and under conditions capable of covalently adding one or more of the selected nucleotide to the terminal nucleotide at the 3? end of the initiator such that the selected nucleotide becomes a terminal nucleotide, and (b) determining whether the selected nucleotide has been added to the terminal nucleotide, wherein if the selected nucleotide has not been added to the terminal nucleotide, then repeating step (a) until the selected nucleotide has been added, and (c) repeating steps (a) and (b) until the polynucleotide is formed.