Abstract: The invention relates to substituted bicyclic compounds, which are useful for inhibition of BET protein function by binding to bromodomains, pharmaceutical compositions comprising these compounds, and use of the compounds and compositions in therapy.

Abstract: One or more techniques and/or systems are provided for incremental transfer with unused data block reclamation. For example, source volume of a source storage filer may have a physical replication relationship with a destination volume of a destination storage filer. Snapshots of a file system of the source volume may be used to identify new data blocks (e.g., data blocks allocated or reallocated to a new snapshot) and/or unused data blocks (e.g., data blocks of a deleted snapshot) used to incrementally update the destination volume so that the destination volume is a mirrored replication of the source volume. In this way, new data blocks may be updated and unused data blocks may be punched out (e.g., deallocated) of the destination volume during execution of an incremental update.

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.

Abstract: Embodiments of the present disclosure are directed to coated glass articles which reduce glass particle formation caused by glass to glass contact in pharmaceutical glass filling lines.

Abstract: Systems and methods for secure collaboration of intellectual property are provided. By way of introductory example, a cloud environment may store a session descriptor indicative of an executable, an input parameter for the executable, and a target recipient. The cloud environment may receive a first and second authorization of the session descriptor from the respective proprietors of the input parameter and the executable. The cloud environment may verify, based on the first authorization and the second authorization, the session descriptor is authorized. The cloud environment may generate, in response to the session descriptor being authorized, a collaboration result based on the executable and the input parameter. The cloud environment may control access to the collaboration result based on the target recipient.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: Systems and methods for resource utilization management, such as resources available through one or more accessible resource facilities. Embodiments provide resource utilization management systems and methods which facilitate user-controlled reservation, access, and accounting for resource utilization. Embodiments implement an electronic user key-based infrastructure to enable access to and accounting for resources. Embodiments include optical recognition or geolocation for each resource for which resource utilization management is provided. A user device, such as a smart phone, personal digital assistant (PDA), or tablet computer, executing a resource utilization management application, may be configured to provide a resource key device which is operable to scan the resource for accessing and relinquishing that resource, whether on an ad hoc and/or reservation basis.

Abstract: The present disclosure relates to substituted pyridinones, which are useful for inhibition of BET protein function by binding to bromodomains, and their use in therapy.

Abstract: A vehicle includes an antenna system and a controller. The controller may be configured to, responsive to wireless energy, received via the antenna system, exceeding a magnitude and duration indicative of a cellular connection from a nomadic device at a predetermined position in the vehicle in an absence of a connection with the device via a local protocol while the vehicle is in motion, operate a powertrain to limit a speed of the vehicle.

Abstract: The present disclosure relates to a construction method for improved tracer ammunition production. There is provided a method of forming a component for a round, said method comprising the step of causing said component to be drawn through at least one floating die.

Abstract: The present invention provides novel compounds and pharmaceutical compositions thereof and methods of using the same for treating cardiovascular diseases.

Abstract: A method for producing work is disclosed. The method includes increasing the pressure of a working fluid including carbon dioxide from a first pressure at least equal to a triple point pressure to a second pressure above the triple point pressure. The method also includes heating the working fluid, extracting mechanical work by expanding a first portion of the heated working fluid to a third pressure, supplying a second portion of the heated working fluid as a motive fluid to an ejector, increasing the pressure of the expanded working fluid by supplying the expanded working fluid to the ejector to combine with the motive fluid and form an output fluid at the fourth pressure, the fourth pressure at least equal to the triple point pressure of the working fluid. The method also includes refrigerating the output fluid to condense a vapor phase into a liquid phase.

Abstract: Disclosed herein are pharmaceutical compositions, comprising a therapeutically effective amount of 4-((1-carboxy-2-(((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)thio)ethyl)amino)-4-oxobutanoic acid, or a pharmaceutically acceptable salt thereof, and at least one protective agent, and uses thereof.

Abstract: Identification of regions-of-interest within cell maps is disclosed. In certain embodiments, identification of the regions-of interest is based on the use of biomarkers selected based on nucleic acid sequence data. The nucleic acid sequence data may be acquired for a homogeneous or heterogeneous set of cells present in the respective tissue sample.

Abstract: A compressor for compressing a gas, the compressor comprising: a housing having an axial inlet and an annular outlet volute; an impeller wheel including a plurality of blades, the wheel being rotatably mounted within the housing between the inlet and outlet volute; the axial inlet being defined by a tubular inducer portion of the housing and the annular outlet volute being defined by an annular diffuser passage surrounding the impeller, the diffuser having an annular outlet communicating with the outlet volute; the housing having an inner wall defining a surface located in close proximity to radially outer edges of the impeller blades which sweep across the surface as the impeller wheel rotates; wherein the compressor housing incorporates at least one section comprised of a deformable, energy absorbing material arranged to deform and absorb energy generated as a result of impeller wheel failure.

Abstract: Provided herein are Aminopurine Compounds having the following structures: wherein R1, R2, and R3 are as defined herein, compositions comprising an effective amount of an Aminopurine Compound, and methods for treating or preventing a cancer, for example, melanoma.

Abstract: Systems and methods which provide resource utilization management, such as with respect to resources available through one or more accessible resource facilities, are disclosed. Embodiments provide resource utilization management systems and methods which facilitate user controlled reservation, access, and accounting for resource utilization. Resource utilization management systems of embodiments implement an electronic user key based infrastructure to enable access to and accounting for resources, such as resources of one or more accessible resource facility. Embodiments comprise unique tags for each resource for which resource utilization management is provided. A user device, such as a smart phone, personal digital assistant (PDA), or tablet computer, executing a resource utilization management application may be configured to provide a resource key device which is operable to scan the unique tag of a resource for accessing and relinquishing that resource, whether on an ad hoc and/or reservation basis.

Abstract: The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of a RRM2 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA or nucleic acid molecules or vectors encoding the same together with a pharmaceutically acceptable carrier; methods for treating diseases caused by the expression of a RRM2 gene using said pharmaceutical composition; and methods for inhibiting the expression of RRM2 in a cell.

Abstract: The subject matter of the present disclosure generally relates to techniques for following a treatment protocol having one or more treatment parameters to cause a targeted physiological outcome at a distal site, assessing an expression level of a gene in a region of interest after completing the treatment protocol, and modifying the one or more treatment parameters based on the expression level of the gene. The treatment protocol may include one or more ultrasound energy treatments to the region of interest.

Abstract: An example system includes a video processing engine. The video processing engine is to combine a plurality of images from a plurality of distinct devices to produce a combined image. The system also includes a display output to display the combined image. The system includes a hub to provide first input data from an input device to a first of the plurality of distinct devices. When combining images, the video processing engine is to emphasize an image from a second of the plurality of distinct devices based on the hub receiving a first type of input. The hub is to provide second input data to the second of the plurality of distinct devices based on the hub receiving a second type of input.