Abstract: A method and system for detecting malicious threat activity or event sequences is disclosed. In an embodiment, the method may include receiving security data from a plurality of data sources and normalizing the security data. The method may include generating one or more statistical profiles for one or more entities based on the normalized data. The method may include generating one or more detectors based on one or more subsequences organized in a plurality of threat chains. The method may include monitoring, via the one or more detectors, telemetric data in real time for the one or more subsequences. The method may include aggregating each detected one or more subsequences. The method may include generating a score based on a correlation of aggregated detected subsequences to the one or more statistical profiles. The method may include, if the score of exceeds a threshold, generating a high severity alert.

Abstract: A controller coupled to plural mobile devices through a mobile communications environment including multiple available networks at a location remote from the plural mobile devices. The plural mobile devices are simultaneously connected to plural networks and collecting network data for each simultaneously connected plural multiple networks. The controller includes a receiver receiving from each mobile device the collected network data, where each mobile device is connected to the receiver via an active one of the simultaneously connected plural multiple networks for transmitting the collected network data; a processor configured to evaluate the collected network data from each mobile device and, based upon respective rules established for each mobile device, to produce respective sets of operating parameters for the plural mobile devices; and a transmitter to transmit to each mobile device the respective sets of operating parameters.

Abstract: This disclosure provides systems and methods for sample processing and data analysis. Sample processing may include nucleic acid sample processing and subsequent sequencing. Some or all of a nucleic acid sample may be sequenced to provide sequence information, which may be stored or otherwise maintained in an electronic storage location. The sequence information may be analyzed with the aid of a computer processor, and the analyzed sequence information may be stored in an electronic storage location that may include a pool or collection of sequence information and analyzed sequence information generated from the nucleic acid sample. Methods and systems of the present disclosure can be used, for example, for the analysis of a nucleic acid sample, for producing one or more libraries, and for producing biomedical reports. Methods and systems of the disclosure can aid in the diagnosis, monitoring, treatment, and prevention of one or more diseases and conditions.

Abstract: The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation.

Abstract: Described herein are systems and methods for work from home solutions according to various embodiments of the invention. These solutions accurately diagnose connectivity issue locations and severity from any, some, or all points in a network framework. Embodiments of these solutions may also use artificial intelligence and machine learning to process customer quality-of-experience (QoE) feedback and other relevant indicators. The solutions may improve network connectivity based on these measurements and processes.

Abstract: An aerosol generating device includes a heating chamber for receiving at least part of an aerosol generating substrate and a plurality of inductively heatable susceptors mounted in the heating chamber. The plurality of inductively heatable susceptors are electrically connected to each other, for example by at least one electrical connectors .

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: Disclosed is a nickel-base alloy comprising, in weight percentages based on total alloy weight: 11 to 18 chromium; 16 to 28 cobalt; 1.5 to 7.0 molybdenum; 0 to 6.5 tungsten; 0 to 1.0 niobium; 1.0 to 2.5 aluminum; 2.0 to 6.0 titanium; 0 to 2.0 tantalum; 0 to 4.0 iron; 0 to 0.5 hafnium; 0.01 to 0.2 carbon; 0.001 to 0.02 boron; 0.001 to 0.1 zirconium; nickel; and impurities. Also disclosed is a nickel-base alloy comprising, in weight percentages based on total alloy weight: 11 to 18 chromium; 24 to 28 cobalt; 1.5 to 7.0 molybdenum; 2.0 to 6.0 tungsten; 0 to 1.0 niobium; 1.0 to 2,5 aluminum; 2,0 to 6.0 titanium; 0 to 2.0 tantalum; 0 to 4.0 iron; 0 to 0.5 hafnium; 0.01 to 0.2 carbon; 0.001 to 0.02 boron; 0.001 to 0.1 zirconium; nickel; and impurities.

Abstract: An information exchange platform referred to as a Trading Grid (TG) may perform relationship-based data processing utilizing a trading partner (TP) graph that describes relationships amongst operating units (OUs) on the TG. When the TG receives a request from an OU to exchange data with a TP, the TG accesses the TP graph and determines a relationship between the OU and their TP as reflected in the TP graph. The TP graph is maintained and controlled by the system independently of the OU and the TP. The TG may route the data based on instructions associated with the relationship that is reflected in the TP graph. The instructions associated with the relationship may specify network based services provided by the TG. An orchestration component may operate to orchestrate the performance of the network based services. The TG then communicates the processed and/or produced data to the TP.

Abstract: The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue.

Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A method includes providing steam to the solid oxide fuel cell stack, splitting exhaust gas from the cell stack into two portions, a first portion directed to a superheater and a second portion directed to an ejector and to a hydrogen separator. At least part of the first portion of the exhaust gas that is directed to the superheater is subsequently boiled in a boiler and then returned to the superheater. After being returned to the superheater, this part is directed to the ejector as high pressure steam so as to drive the ejector.

Abstract: A method and system for detecting malicious threat activity or event sequences is disclosed. In an embodiment, the method may include generating one or more malicious sequence detection rules defined in a domain specific language. The method may include generating a rules repository configured to receive and store one or more pre-defined rules and one or more curated sets of malicious sequence detection rules. The method may include monitoring networks and/or computing devices to detect malicious threat activity or event sequences based on the one or more curated sets of malicious sequence detection rules. The method may include aggregating malicious threat activity or event sequences detected within a predetermined time frame and generating a threat score and, if the threat score exceeds a threshold score, generating an alert.

Abstract: A non-limiting embodiment of a titanium alloy comprises, in weight percentages based on total alloy weight: 2.0 to 5.0 aluminum; 3.0 to 8.0 tin; 1.0 to 5.0 zirconium; 0 to a total of 16.0 of one or more elements selected from the group consisting of oxygen, vanadium, molybdenum, niobium, chromium, iron, copper, nitrogen, and carbon; titanium; and impurities. A non-limiting embodiment of the titanium alloy comprises an intentional addition of tin and zirconium in conjunction with certain other alloying additions such as aluminum, oxygen, vanadium, molybdenum, niobium, and iron, to stabilize the ? phase and increase the volume fraction of the ? phase without the risk of forming embrittling phases, which was observed to increase room temperature tensile strength while maintaining ductility.

Abstract: Disclosed are systems and methods for generating graphical displays of analyte data and/or health information. In some implementations, the graphical displays are generating based on a self-referential dataset that are modifiable based on identified portions of the data. The modified graphical displays can indicate features in the analyte data of a host.

Abstract: A non-limiting embodiment of a titanium alloy comprises, in weight percentages based on total alloy weight: 5.5 to 6.5 aluminum; 1.5 to 2.5 tin; 1.3 to 2.3 molybdenum; 0.1 to 10.0 zirconium; 0.01 to 0.30 silicon; 0.1 to 2.0 germanium; titanium; and impurities. A non-limiting embodiment of the titanium alloy comprises a zirconium-silicon-germanium intermetallic precipitate, and exhibits a steady-state creep rate less than 8×10?4 (24 hrs)?1 at a temperature of at least 890° F. under a load of 52 ksi.

Abstract: A controller and method of controlling a mobile device. The controller is coupled to a mobile device through a mobile communications environment. The controller is coupled to the mobile communications environment at a location remote from the mobile device, and includes a receiver that receives data from the mobile device, a processor that evaluates the data received from the mobile device based upon rules for the mobile device, and a transmitter that sends data to the mobile device to at least one of alert the user to a condition and modify current operating parameters on the mobile device.

Abstract: Apparatuses for a hydrant, as well as associated methods for installing the same, may be directed to a threaded stem for actuating a hydrant outlet valve at a first end of the stem. An attachment nut may define a bore for supporting the stem in the hydrant. The attachment nut defines a cavity configured to receive water from a barrel of the hydrant. The attachment nut also defines a water access passage extending through an outer wall of the attachment nut to the cavity. The apparatus also includes a sensor in fluid communication with the cavity to obtain sensor data for the water in the barrel.