Abstract: Provided herein are KRAS G12C inhibitors, composition of the same, and methods of using the same. These inhibitors are useful for treating a number of disorders, including pancreatic, colorectal, and lung cancers.

Abstract: Systems and techniques for detecting a difference in orientation between a lawn mower and a surface on which the mower is mowing, or between portions of such surface, based on one or more of sensor data or map data are discussed. The difference in orientation may then be used to control the lawn mower by, for example, raising a deck height or idling a blade speed, though other actuations are contemplated. In some examples, an amount the deck height is raised may be based on the difference in orientation. Based on a subsequent difference detected being at or below a threshold difference, the mower may return to previous operating conditions including, but not limited to, returning a blade speed to a previous blade speed and/or returning the deck height to a previous deck height, among other controls.

Abstract: A filter and kit assembly for securing to one or more intake surfaces associated with a V-shaped heat exchanger unit. A screen includes a reinforced edge, within which is configured a plurality of spaced apart grommets aligning with and receiving therethrough engaging portions of the fasteners. In one variant, a frame is constructed for supporting the fasteners and attached filter and which is subsequently secured by clips against a flange surface surrounding the intake opening. In a further variant, the screen is configured in wrap-around fashion for supporting against first and second consecutively arranged intake openings along with an interconnecting intermediate flange surface.

Abstract: A tape dispenser housing wound adhesive tape includes a brake spoke tapering (i.e., narrowing) from a distal radial end to a proximal radial end relative to a tape rotational axis, wherein the brake spoke effectuates the braking of wound adhesive tape on a hub by contacting the wound adhesive tape, the hub, or both simultaneously.

Abstract: The present invention relates to RNAi constructs for reducing expression of the ASGR1 gene. Methods of using such RNAi constructs to treat or prevent cardiovascular disease, such as coronary artery disease and myocardial infarction, and to reduce serum non-HDL cholesterol levels are also described.

Abstract: The present systems, devices, and methods relate to managing shared vehicle access. Vehicle access can be provided to a candidate user based on whether the user is included in a list of at least one user associated with a respective virtual key. Virtual keys can be created, or lists of at least one user can be updated to include the candidate user, to in turn provide vehicle access. Virtual keys can be stored in a plurality of virtual key slots, with vehicle access being provided based on a virtual key stored in an active key slot. Status reports can be sent to a reservation management device, for updating virtual keys or lists of at least one user.

Abstract: The present systems, devices, and methods relate to managing shared vehicle access. Vehicle access can be provided to a candidate user based on whether the user is included in a list of at least one user associated with a respective virtual key. Virtual keys can be created, or lists of at least one user can be updated to include the candidate user, to in turn provide vehicle access. Virtual keys can be stored in a plurality of virtual key slots, with vehicle access being provided based on a virtual key stored in an active key slot. Status reports can be sent to a reservation management device, for updating virtual keys or lists of at least one user.

Abstract: The present systems, devices, and methods relate to managing shared vehicle access. Vehicle access can be provided to a candidate user based on whether the user is included in a list of at least one user associated with a respective virtual key. Virtual keys can be created, or lists of at least one user can be updated to include the candidate user, to in turn provide vehicle access. Virtual keys can be stored in a plurality of virtual key slots, with vehicle access being provided based on a virtual key stored in an active key slot. Status reports can be sent to a reservation management device, for updating virtual keys or lists of at least one user.

Abstract: The present systems, devices, and methods relate to managing shared vehicle access. Vehicle access can be provided to a candidate user based on whether the user is included in a list of at least one user associated with a respective virtual key. Virtual keys can be created, or lists of at least one user can be updated to include the candidate user, to in turn provide vehicle access. Virtual keys can be stored in a plurality of virtual key slots, with vehicle access being provided based on a virtual key stored in an active key slot. Status reports can be sent to a reservation management device, for updating virtual keys or lists of at least one user.

Abstract: An exercise weight support device includes: a spool connected to a belt to suspend the device, the spool being rotatable to enable more or less of the belt to be wound therearound to change the device vertical position of the device; a ratchet wheel drivingly coupled to the spool to control rotation thereof; an outer frame having a cradle and/or a pair of hooks to support a bar of a free weight; a ratchet pawl connected to the outer frame at a fixed location relative thereto; and a trigger handle coupled to the spool to move the spool relative to the ratchet pawl between a non-operating position of the trigger handle causing the ratchet pawl and teeth of the ratchet wheel to engage, and an operating position of the trigger handle causing the ratchet pawl and the teeth of the ratchet wheel to disengage to control rotation of the spool.

Abstract: Various techniques are provided to implement fast boot for programmable logic devices (PLDs). In one example, a method includes performing a read operation on a non-volatile memory to obtain a first value. The method further includes comparing the value to a predetermined value to obtain a comparison result. The method further includes determining whether a boot image stored on the non-volatile memory is to be read based at least on the first comparison result. The method further includes performing, based on the determining, a read operation on the boot image to obtain data associated with booting of a device. The method further includes booting the device based at least on the data. Related systems and devices are provided.

Abstract: A central command system may determine a mission plan for resilient execution by a swarm of drones comprising one or more sensors to capture data in accordance with the mission plan. The mission plan may specify requirements for fault tolerance or parallelism and a redundancy structure for the swarm. The mission plan may be transmitted to a remote drone swarm controller device that determines a swarm configuration based on the mission plan and available drones. The controller may transmit instructions regarding the swarm configuration to dispatch a resilient swarm of drones. During execution of the mission plan, drones in the resilient swarm may be monitored by other drones in the swarm, by the remote drone swarm controller, and/or by the central command system. The redundancy structure provides for failover options for one or more drones in the resilient swarm.

Abstract: The present systems, devices, and methods relate to managing shared vehicle access. Vehicle access can be provided to a candidate user based on whether the user is included in a list of at least one user associated with a respective virtual key. Virtual keys can be created, or lists of at least one user can be updated to include the candidate user, to in turn provide vehicle access. Virtual keys can be stored in a plurality of virtual key slots, with vehicle access being provided based on a virtual key stored in an active key slot. Status reports can be sent to a reservation management device, for updating virtual keys or lists of at least one user.

Abstract: Systems and techniques for generating a set of connected segments for a device or system to traverse in order to reach every point of the region (a coverage plan). Nodes defining the region to be traversed define a polygon. The polygon is decomposed into a mesh and a graph of the mesh is generated. The graph may be used to determine a longest funneled path which, in turn, may be used to either optimize for a longest path or to divide the polygon for eroding sides. The longest path and/or erosions are used to define a set of segments. The segments are connected, which in some examples is done via an optimization to minimize an amount of time or energy to traverse all segments and connections. The resultant coverage plan is sent to a system configured to receive the plan and traverse the region.

Abstract: The present systems, devices, and methods relate to managing shared vehicle access. Vehicle access can be provided to a candidate user based on whether the user is included in a list of at least one user associated with a respective virtual key. Virtual keys can be created, or lists of at least one user can be updated to include the candidate user, to in turn provide vehicle access. Virtual keys can be stored in a plurality of virtual key slots, with vehicle access being provided based on a virtual key stored in an active key slot. Status reports can be sent to a reservation management device, for updating virtual keys or lists of at least one user.

Abstract: An exercise weight support device includes: a spool connected to a belt to suspend the device, the spool being rotatable to enable more or less of the belt to be wound therearound to change the vertical position of the device; a ratchet wheel drivingly coupled to the spool to control rotation thereof; an outer frame having a cradle and/or pair of hooks to support a bar of a free weight; a ratchet pawl connected to the outer frame at a fixed location relative thereto; and a trigger handle coupled to the spool to move the spool relative to the ratchet pawl between a non-operating position of the trigger handle causing the ratchet pawl and teeth of the ratchet wheel to engage, and an operating position of the trigger handle causing the ratchet pawl and teeth to disengage to control rotation of the spool.

Abstract: System, apparatus, device and methods relating to a telematic vehicle sharing platform ecosystem and a telematic vehicle share I/O expander to automate sharing and management of a vehicle that is shared by more than one operator.

Abstract: A method of aligning a plurality of color channels of a projector is provided. The method includes: for each color channel, (i) projecting test pattern on a surface; (ii) capturing image of the test pattern generated on the surface; and (iii) adding the captured image to an image set. Once the captured images for each color channel are added to an image set, identifying a reference position based on the image set. This is followed by processing the image set to estimate a divergence of the respective test patterns for each color channel with respect to the reference position, followed by computing a corrective function for each color channel and applying the respective corrective function to each color channel to align the color channel to the reference position.

Abstract: System, apparatus, device and methods relating to a telematic vehicle sharing platform ecosystem and a telematic vehicle share I/O expander to automate sharing and management of a vehicle that is shared by more than one operator.