Patents by Inventor John Howard Hutchinson

John Howard Hutchinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Uses of a lysyl oxidase-like 2 inhibitor
    Patent number: 11793797
    Abstract: Described herein is the use of a LOXL2 inhibitor in the treatment or prevention of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: October 24, 2023
    Assignee: PHARMAKEA, INC.
    Inventors: Gretchen Bain, Jillian Frances Evans, Deidre A. Mackenna, John Howard Hutchinson
  • Autotaxin inhibitor compounds
    Patent number: 11779568
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: May 6, 2022
    Date of Patent: October 10, 2023
    Assignee: Sabre Therapeutics LLC
    Inventors: John Howard Hutchinson, David Lonergan
  • METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF
    Publication number: 20230113588
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: August 8, 2022
    Publication date: April 13, 2023
    Inventors: Nicholas David Peter COSFORD, Dhanya RAVEENDRA-PANICKAR, Douglas J. SHEFFLER, John Howard HUTCHINSON, Reto Andreas GADIENT
  • Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof
    Patent number: 11447453
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: March 12, 2020
    Date of Patent: September 20, 2022
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Nicholas David Peter Cosford, Dhanya Raveendra-Panickar, Douglas J. Sheffler, John Howard Hutchinson, Reto Andreas Gadient
  • AUTOTAXIN INHIBITOR COMPOUNDS
    Publication number: 20220265608
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Application
    Filed: May 6, 2022
    Publication date: August 25, 2022
    Inventors: John Howard Hutchinson, David Lonergan
  • Lysyl oxidase-like 2 inhibitors and uses thereof
    Patent number: 11358936
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Grant
    Filed: July 17, 2020
    Date of Patent: June 14, 2022
    Assignee: PharmAkea, Inc.
    Inventors: Martin W. Rowbottom, John Howard Hutchinson, David Lonergan
  • Autotaxin inhibitor compounds
    Patent number: 11344533
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: May 31, 2022
    Assignee: Sabre Therapeutics LLC
    Inventors: John Howard Hutchinson, David Lonergan
  • Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
    Patent number: 11072585
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Grant
    Filed: December 13, 2019
    Date of Patent: July 27, 2021
    Assignee: PHARMAKEA, INC.
    Inventors: Martin W. Rowbottom, John Howard Hutchinson, Imelda Calderon
  • Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
    Patent number: 11058676
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Grant
    Filed: August 27, 2019
    Date of Patent: July 13, 2021
    Assignee: PHARMAKEA, INC.
    Inventors: Martin W. Rowbottom, John Howard Hutchinson
  • USES OF A LYSYL OXIDASE-LIKE 2 INHIBITOR
    Publication number: 20210177820
    Abstract: Described herein is the use of a LOXL2 inhibitor in the treatment or prevention of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: February 3, 2021
    Publication date: June 17, 2021
    Inventors: Gretchen BAIN, Jillian Frances EVANS, Deidre A. MACKENNA, John Howard HUTCHINSON
  • LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20210171465
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: July 17, 2020
    Publication date: June 10, 2021
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON, David LONERGAN
  • METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF
    Publication number: 20200347021
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Application
    Filed: March 12, 2020
    Publication date: November 5, 2020
    Inventors: Nicholas David Peter COSFORD, Dhanya RAVEENDRA-PANICKAR, Douglas J. SHEFFLER, John Howard HUTCHINSON, Reto Andreas GADIENT
  • Lysyl oxidase-like 2 inhibitors and uses thereof
    Patent number: 10766860
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: September 8, 2020
    Assignee: PHARMAKEA, INC.
    Inventors: Martin W. Rowbottom, John Howard Hutchinson, David Lonergan
  • AUTOTAXIN INHIBITOR COMPOUNDS
    Publication number: 20200268713
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Application
    Filed: May 14, 2020
    Publication date: August 27, 2020
    Inventors: John Howard HUTCHINSON, David LONERGAN
  • AUTOTAXIN INHIBITORS AND USES THEREOF
    Publication number: 20200215034
    Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with autotaxin activity. The methods and compositions disclosed herein include the use of at least one autotaxin inhibitor compound.
    Type: Application
    Filed: March 17, 2020
    Publication date: July 9, 2020
    Inventors: Gretchen BAIN, Jillian Frances EVANS, John Howard HUTCHINSON, David LONERGAN
  • Autotaxin inhibitor compounds
    Patent number: 10688081
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: May 3, 2018
    Date of Patent: June 23, 2020
    Assignee: SABRE THERAPEUTICS LLC
    Inventors: John Howard Hutchinson, David Lonergan
  • Autotaxin inhibitors and uses thereof
    Patent number: 10632104
    Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with autotaxin activity. The methods and compositions disclosed herein include the use of at least one autotaxin inhibitor compound.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: April 28, 2020
    Assignee: SABRE THERAPEUTICS LLC
    Inventors: Gretchen Bain, Jillian Frances Evans, John Howard Hutchinson, David Lonergan
  • FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20200115341
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: December 13, 2019
    Publication date: April 16, 2020
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON, Imelda CALDERON
  • Metabotropic glutamate receptor negative allosteric modulators (NAMs) and uses thereof
    Patent number: 10597367
    Abstract: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
    Type: Grant
    Filed: April 11, 2018
    Date of Patent: March 24, 2020
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Nicholas David Peter Cosford, Dhanya Raveendra-Panickar, Douglas J. Sheffler, John Howard Hutchinson, Reto Andreas Gadient
  • Quinolinone lysyl oxidase-like 2 inhibitors and uses thereof
    Patent number: 10588900
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: March 17, 2020
    Assignee: PHARMAKEA, INC.
    Inventors: Martin W. Rowbottom, John Howard Hutchinson