Patents by Inventor John Howard Hutchinson

John Howard Hutchinson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
    Patent number: 10570094
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: February 25, 2020
    Assignee: PHARMAKEA, INC.
    Inventors: Martin W. Rowbottom, John Howard Hutchinson, Imelda Calderon
  • QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20200022972
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: August 27, 2019
    Publication date: January 23, 2020
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON
  • CHEMICAL PROBES OF LYSYL OXIDASK-LIKE 2 AND USES THEREOF
    Publication number: 20190192697
    Abstract: Described herein are probe compounds that interact with the LOXL2 receptor, methods of making such probe compounds, and methods of using such probe compounds in vitro and in vivo.
    Type: Application
    Filed: September 6, 2017
    Publication date: June 27, 2019
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON, Jillian Frances EVANS, Gretchen BAIN
  • USES OF A LYSYL OXIDASE-LIKE 2 INHIBITOR
    Publication number: 20190192495
    Abstract: Described herein is the use of a LOXL2 inhibitor in the treatment or prevention of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: September 6, 2017
    Publication date: June 27, 2019
    Inventors: Gretchen BAIN, Jillian Frances EVANS, Deidre A. MACKENNA, John Howard HUTCHINSON
  • FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20190119211
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: September 21, 2018
    Publication date: April 25, 2019
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON, Imelda CALDERON
  • QUINOLINONE LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20190046520
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: February 7, 2017
    Publication date: February 14, 2019
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON
  • Fluorinated lysyl oxidase-like 2 inhibitors and uses thereof
    Patent number: 10150732
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: December 11, 2018
    Assignee: PHARMAKEA, INC.
    Inventors: Martin W. Rowbottom, John Howard Hutchinson, Imelda Calderon
  • AUTOTAXIN INHIBITOR COMPOUNDS
    Publication number: 20180243267
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Application
    Filed: May 3, 2018
    Publication date: August 30, 2018
    Inventors: John Howard HUTCHINSON, David LONERGAN
  • LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20180215727
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: July 18, 2016
    Publication date: August 2, 2018
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON
  • LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20180186755
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: June 24, 2016
    Publication date: July 5, 2018
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON
  • Autotaxin inhibitor compounds
    Patent number: 9999615
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: June 19, 2018
    Assignee: PHARMAKEA, INC.
    Inventors: John Howard Hutchinson, David Lonergan
  • TETRACYCLIC AUTOTAXIN INHIBITORS
    Publication number: 20180162859
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Application
    Filed: February 8, 2018
    Publication date: June 14, 2018
    Inventors: John Howard Hutchinson, David Lonergan, Martin Rowbottom, Andiliy Gokching Lai
  • AUTOTAXIN INHIBITORS AND USES THEREOF
    Publication number: 20180147185
    Abstract: Described herein are methods and compositions for the treatment of conditions, diseases, or disorders associated with autotaxin activity. The methods and compositions disclosed herein include the use of at least one autotaxin inhibitor compound.
    Type: Application
    Filed: May 24, 2016
    Publication date: May 31, 2018
    Applicant: PharmAkea, Inc.
    Inventors: Gretchen BAIN, Jillian Frances EVANS, John Howard HUTCHINSON, David LONERGAN
  • Heterocyclic vinyl autotaxin inhibitor compounds
    Patent number: 9951026
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: April 24, 2018
    Assignee: PHARMAKEA, INC.
    Inventors: John Howard Hutchinson, Timothy Andrew Parr, Kevin Duane Bunker, David Lonergan
  • Tetracyclic autotaxin inhibitors
    Patent number: 9926318
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: March 27, 2018
    Assignee: PHARMAKEA, INC.
    Inventors: John Howard Hutchinson, David Lonergan, Martin Rowbottom, Andiliy Gokching Lai
  • LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20180057458
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: March 3, 2016
    Publication date: March 1, 2018
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON, David LONERGAN
  • FLUORINATED LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF
    Publication number: 20170369443
    Abstract: Described herein are compounds that are LOXL2 inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with LOXL2 activity.
    Type: Application
    Filed: September 5, 2017
    Publication date: December 28, 2017
    Inventors: Martin W. ROWBOTTOM, John Howard HUTCHINSON, Imelda CALDERON
  • Autotaxin inhibitor compounds
    Patent number: 9850203
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: December 26, 2017
    Assignee: PHARMAKEA, INC.
    Inventors: John Howard Hutchinson, David Lonergan, Fei Huang, Martin Rowbottom, Imelda Calderon
  • Autotaxin inhibitors and uses thereof
    Patent number: 9849109
    Abstract: Described herein are compounds that are inhibitors of autotaxin. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such inhibitors, alone and in combination with other compounds, for treating autotaxin-dependent or autotaxin-mediated conditions or diseases.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: December 26, 2017
    Assignee: AMIRA PHARMACEUTICALS, INC.
    Inventors: Jeffrey Roger Roppe, Timothy Andrew Parr, Nicholas Simon Stock, Deborah Volkots, John Howard Hutchinson
  • Vinyl autotaxin inhibitor compounds
    Patent number: 9714240
    Abstract: Described herein are compounds that are autotaxin inhibitors, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with autotaxin activity.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: July 25, 2017
    Assignee: PHARMAKEA, INC.
    Inventors: John Howard Hutchinson, Timothy Andrew Parr, David Lonergan