Abstract: A shingle includes a body having an upper end, a lower end, a top surface, a bottom surface, a first side and a second side. The body has a width defined as the distance between the two opposing sides, a length defined by the distance between the upper end and the lower end. In a preferred embodiment, the shingle also includes a side wall that extends downward from the body adjacent one of the sides and extends the length of the shingle. The side wall preferably includes an angular projection disposed toward the upper end.

Abstract: A hardware-based acceleration platform for computational electromagnetic algorithms, specifically the finite-difference time-domain (“FDTD”) method, comprises reformulating the FDTD algorithm in order to make it more hardware friendly. This reformulation makes use of split fields at every node in the mesh, and combines total- and scattered-field formulations into a single, hybrid formulation. By precomputing coefficients for the nodes in the mesh, it is possible for a single set of equations to support plane waves, point sources, PML ABCs, and PEC walls. In the method sources are determined by means of a lookup table, rather than through direct hardware computations. All of these modifications enable the hardware designer to much more easily develop an FDTD accelerator.

Abstract: The invention provides a controlled-release pharmaceutical formulation for oral administration comprising 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable adjuvant, diluent or carrier; characterized in that the formulation is adapted to release at least 50% by weight of the 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline, or the pharmaceutically acceptable salt thereof, after 6 hours in Apparatus 1 described in the United States Pharmacopoeia 24 (2000), pp 1941–1943, having 1 litre vessels, baskets of 40 mesh (0.4 mm apertures), a rotation speed of 100 rpm, and a dissolution medium consisting of 900 ml of 0.01 M hydrochloric acid containing 0.7% w/v sodium chloride at 37° C. Formulations according to the invention are suitable for the treatment of BPH.

Abstract: Disclosed is a coated synthetic shingle that exhibits increased resistance to ultra-violet radiation. The shingle is useable for roofing applications and includes a substrate having a substrate surface and a base coat that is applied to the substrate surface. The base coat preferably includes a first fluoropolymer component. The shingle can also include a top coat that is applied to the base coat. The top coat preferably includes a clear acrylic coating. A method for manufacturing the shingle is also disclosed.

Abstract: The present invention comprises a graphical user interface tool particularly adapted for use with a program that shows multiple files simultaneously, each in a different panel of the display. The tool presents the user with a series of optional actions that can be taken in connection with the file that is displayed within one panel of the display. In accordance with the invention, a user manipulates a cursor to a position in one of the multiple panels on a display screen and issues an instruction to invoke the tool, such as by clicking on the right mouse button. The tool is then made to appear and displays a series of optional operations from which the user may select. The operations are specific to the file in the panel within which the tool was invoked.

Abstract: The invention pertains to new pyrrolidyl derivatives of benzo-fused aza heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE-10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders. The invention relates also to methods for treating neurodegenerative and psychiatric disorders, for example psychosis and disorders comprising deficient cognition as a symptom.

Abstract: A method for ballistic target defense including identifying a launched ballistic target having a target launch point, a target launch direction, a target speed, and a target trajectory; launching a target interceptor in a launch direction that is generally the same as the target launch direction and with a speed that is less than the target speed; providing the interceptor with an approximate target intercept trajectory, and accelerating the interceptor at an approximate point of intercept to substantially match the target trajectory. During a relatively long target engagement time, the interceptor has approximately a zero net relative velocity with respect to the target.

Abstract: The invention pertains to heteroaromatic compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.

Abstract: A portable turnout system for temporary connection of a rail line to a spur line includes a ramp section having a frame and two parallel rails mounted thereon, the parallel rails each having a forward end and a rearward end higher than the forward end such that the parallel rails have a positive grade from forward end to rearward end and a portable transfer track including at least one portable track section having a frame and two parallel rails mounted thereon, the portable transfer track releasably connectable at one end thereof to the rearward end of the parallel rails of the ramp section in an elevated position above the rail line. At least one portable transfer track support device supports the portable transfer track in the elevated position above the rail line and the portable transfer track is releasably connectable at the opposite end thereof to a spur line.

Abstract: A system for producing, stabilizing, and concentrating tri-atomic hydrogen includes a source of liquid hydrogen in the form of para-hydrogen, a piping system through which the liquid hydrogen flows, an injection point for combining the liquid hydrogen in the form of para-hydrogen with third hydrogen atoms all with the same proton spin to form H3 all with the same net magnetic orientation, and a continuous magnetic field for maintaining the magnetic orientation. The system further has a storage tank for storing concentrated liquid H3 molecules for use as a propellant.

Abstract: The invention pertains to new piperidyl-substituted quinazoline and isoquinoline derivatives that serve as effective phosphodiesterase (PDE) inhibitors. The invention also relates to compounds that are selective inhibitors of PDE10. The invention further relates to intermediates for preparation of such compounds; pharmaceutical compositions comprising such compounds; and the use of such compounds in methods for treating certain central nervous system (CNS) or other disorders.

Abstract: 3-amino-2-phenylpyrrolidine compounds useful as NK-1 antagonists, with pharmaceutical compositions and methods of treatment comprising same, are disclosed.

Abstract: A hardware-based acceleration platform for computational electromagnetic algorithms, specifically the finite-difference time-domain (“FDTD”) method, comprises reformulating the FDTD algorithm in order to make it more hardware friendly. This reformulation makes use of split fields at every node in the mesh, and combines total- and scattered-field formulations into a single, hybrid formulation. By precomputing coefficients for the nodes in the mesh, it is possible for a single set of equations to support plane waves, point sources, PML ABCs, and PEC walls. In the method sources are determined by means of a lookup table, rather than through direct hardware computations. All of these modifications enable the hardware designer to much more easily develop an FDTD accelerator.

Abstract: A roller bar security device includes a longitudinally extending tubular member having first and second ends and a plurality of rigid overlapping outwardly extending blades each of which has a generally triangular shape with a base mounted on the tubular member and a sharp point at its apex. The blades are fixed to and extend around and along the tubular member with the apexes of alternate longitudinally spaced blades facing in generally opposite directions. A mounting bracket and bearing are provided for rotatably mounting the tubular member and blades on top of a wall or the like so that the sharp points and edges will deter a potential intruder from climbing over the security device.

Abstract: The invention pertains to substituted quinazoline and isoquinoline compounds that serve as effective phosphodiesterase (PDE) inhibitors. In particular, the invention relates to said compounds which are selective inhibitors of PDE-10. The invention also relates to intermediates for preparation of said compounds; pharmaceutical compositions comprising said compounds; and the use of said compounds in a method for treating certain central nervous system (CNS) or other disorders.

Abstract: A computer hardware configuration for performing the pseudo-spectral time-domain (PSTD) method on data. The hardware configuration includes a forward fast Fourier transform (FFT) unit that calculates a forward fast Fourier transform (FFT) from the data, and a complex multiplication unit that receives the FFT-processed data and calculates a spatial derivative in the frequency domain from the FFT-processed data. The hardware configuration further includes an inverse fast Fourier transform (IFFT) unit that converts the spatial derivative in the frequency domain from the complex multiplication unit into the time domain, and a computation engine that solves a PSTD equation based upon the spatial derivative in the time domain received from the IFFT unit.

Abstract: Disclosed herein is an organization of cache memory for hardware acceleration of the FDTD method. The organization of cache memory for hardware acceleration of the FDTD method provides a substantial speedup to the finite-difference time-domain (FDTD) algorithm when implemented in a piece of digital hardware. The organization of cache memory for hardware acceleration of the FDTD method utilizes a very high bandwidth dual-port on-chip memory in a particular way. By creating many small banks of internal memory and arranging them carefully, all data dependencies can be statically wired. This allows for a many-fold speedup over SRAM-based solutions and removes the burden of data dependence calculation that streaming SDRAM-based solutions must perform.

Abstract: The present invention is concerned with pharmaceutical compositions comprising a mixture of amlodipine enantiomers, which compositions have both anti-hypertensive and additional cardiovascular properties derived respectively from their calcium channel-blocking activity and their ability to release vascular nitric oxide (NO).

Abstract: In combination, an elongated tool having a striking end and a tapered insertion end and a drift pin cap. The drift pin cap includes a cap body having an upper end, a lower end and at least one side wall extending between and connecting the upper end and the lower end. A drift pin receiving cavity is formed in the lower end of the cap body which extends upwards towards the upper end within the cap body, the pin receiving cavity having a diameter smaller than a diameter of the cap body. The pin receiving cavity is operative to fit over and be retained on the striking end of the tool such that when the tool is impacted by a driving device, the drift pin cap is interposed between the tool and the driving device to prevent damage to the tool yet still permit driving of the tool.

Abstract: The present invention provides a combination of (a) eletriptan, or a pharmaceutically acceptable salt thereof, and (b) sodium bicarbonate. The combination provides a rapid absorption of eletriptan when taken orally. The combination is useful for the treatment or prevention of a disease for which a 5-HT1 agonist is indicated, particularly for the treatment of migraine or for the prevention of migraine recurrence.