Abstract: Methods and kits are provided for the detection and quantification of a protein. The methods comprise immobilizing the protein of interest on a substrate, the protein comprising an epitope and another portion, contacting the immobilized protein with a labeled ligand that binds to the epitope to yield a detectably labeled protein, detecting the detectably labeled protein, and quantifying the detectably labeled protein, and the kits comprise a sample of a standard protein, wherein the standard protein comprises an epitope and the sample is of a known concentration of the standard protein, and an aliquot of a labeled primary antibody having specificity for the epitope.

Abstract: The present invention comprises a graphical user interface tool particularly adapted for use with a program that shows multiple files simultaneously, each in a different panel of the display. The tool presents the user with a series of optional actions that can be taken in connection with the file that is displayed within one panel of the display. In accordance with the invention, a user manipulates a cursor to a position in one of the multiple panels on a display screen and issues an instruction to invoke the tool, such as by clicking on the right mouse button. The tool is then made to appear and displays a series of optional operations from which the user may select. The operations are specific to the file in the panel within which the tool was invoked.

Abstract: The present invention is directed to a a method for the treatment of irritable bowel syndrome comprising the multiple daily pulse dosing of an immediate release formulation of the anti-muscarinic darifenacin. Dosing two or three times a day is particularly preferred.

Abstract: The invention provides a controlled-release pharmaceutical formulation for oral administration comprising 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable adjuvant, diluent or carrier; characterized in that the formulation is adapted to release at least 50% by weight of the 4-amino-6,7-dimethoxy-2-(5-methanesulfonamido-1,2,3,4-tetrahydroisoquinol-2-yl)-5-(2-pyridyl)quinazoline, or the pharmaceutically acceptable salt thereof, after 6 hours in Apparatus 1 described in the United States Pharmacopoeia 24 (2000), pp 1941-1943, having 1 litre vessels, baskets of 40 mesh (0.4 mm apertures), a rotation speed of 100 rpm, and a dissolution medium consisting of 900 ml of 0.01 M hydrochloric acid containing 0.7% w/v sodium chloride at 37° C.

Abstract: The present invention is directed to a a method for the treatment of irritable bowel syndrome comprising the multiple daily pulse dosing of an immediate release formulation of the anti-muscarinic darifenacin. Dosing two or three times a day is particularly preferred.

Abstract: A composition comprising eletriptan and a p-glycoprotein (p-gp) inhibitor useful for the treatment of migraine. The bioavailability of eletriptan can be increased by co-administering eletriptan with a p-gp inhibitor. The eletriptan and p-gp inhibitor can be administered together in a composition or as separate components. If administered separately, they can be embodied as a kit. Also provided is a method of treating migraine using said composition or sequential administration of components.

Abstract: A switch heater cover support rack includes at least one upwardly extending upright support unit including a ground-engaging base section, at least two generally horizontal cover support arms mounted on and extending generally perpendicular to the upwardly extending upright support unit and a locking device for releasably securing switch covers on the generally horizontal cover support arms.

Abstract: The present invention concerns a wafer composition comprising: a polymer substrate; a surfactant; and water; characterised in that the wafer further comprises stable, i.e. stable of size and form, crystalline particles of a pharmaceutically active wound healing agent.

Abstract: The present invention relates to an inhaled formulation comprising a compound selected from a particular class of 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-a]pyridines which is capable of delivering the compound as fine, solid particles to the lung and the use of such a formulation in the treatment of certain diseases such as respiratory diseases. By the use of such formulations, it is possible to eliminate the unwanted cough response associated with the use of these compounds in solution metered dose inhalers, which response can prevent the administration of a therapeutically effective dose and, in the long term, undermine patient compliance.

Abstract: The present invention relates to an inhaled formulation comprising a combination of a compound selected from a particular class of 5,6-dihydro-9H-pyrazolo[3,4-c]-1,2,4-triazolo[4,3-a]pyridines of the formula (I) and a tiotropium salt or solvate thereof, which is capable of delivering the compound of the formula (I) as fine, solid particles to the lung. The invention also relates to the use of such a formulation in the treatment of certain diseases such as respiratory diseases. By the use of such formulations, it is possible to eliminate the unwanted cough response associated with the use of the compounds of the formula (I) in solution metered dose inhalers, which response can prevent the administration of a therapeutically effective dose and, in the long term, undermine patient compliance.

Abstract: A composition comprising eletriptan and a p-glycoprotein (p-gp) inhibitor useful for the treatment of migraine. The bioavailability of eletriptan can be increased by co-administering eletriptan with a p-gp inhibitor. The eletriptan and p-gp inhibitor can be administered together in a composition or as separate components. If administered separately, they can be embodied as a kit. Also provided is a method of treating migraine using said composition or sequential administration of components.

Abstract: A switch heater cover support rack includes at least one upwardly extending upright support unit including a ground-engaging base section, at least two generally horizontal cover support arms mounted on and extending generally perpendicular to the upwardly extending upright support unit and a locking device for releasably securing switch covers on the generally horizontal cover support arms.

Abstract: The present invention is concerned with pharmaceutical compositions comprising a mixture of amlodipine enantiomers, which compositions have both anti-hypertensive and additional cardiovascular properties derived respectively from their calcium channel-blocking activity and their ability to release vascular nitric oxide (NO).

Abstract: There is provided a pharmaceutical dosage form adapted for administration to the gastrointestinal tract of a patient, comprising darifenacin, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable adjuvant, diluent or carrier, characterized in that the dosage form is adapted to deliver at least 10% by weight of the darifenacin, or the pharmaceutically acceptable salt thereof, to the lower gastrointestinal tract of the patient. The formulation minimizes unwanted side-effects and increases the bioavailability of darifenacin.

Abstract: A rail flange securement clamp for adjustably mounting a switch point roller assist apparatus on a railroad rail includes a base plate and a top plate, the top plate generally upwardly spaced from the base plate and an adjustable connection device extending between and connecting the base plate and top plate for increasing and decreasing the distance between the base plate and top plate. A rail flange engagement plate having a base section and a rail flange engagement section is adjustably mounted on the securement clamp above the top plate such that the base section is mounted above the top plate and the rail flange engagement section extends outwardly from the top plate for engagement of a flange of a railroad rail thus securing a switch point roller assist apparatus on the railroad rail.

Abstract: A switch point roller assist apparatus includes an elongated main support structure on which is movably mounted a rail securement clamp for releasably adjustably connecting the main support structure to a railroad rail. An elongated tie bar is adjustably mounted on the main support structure generally perpendicular to the main support structure. A roller support cage is pivotally adjustably mounted on the main support structure, the roller support cage supporting at least one roller rotatably mounted thereon, each roller mounted generally perpendicular to the main support structure. The tie bar is adjustably mounted to the main support structure such that the position of the tie bar is vertically adjustable relative to the main support structure. Finally, the roller support cage is adjustably mounted on the main support structure such that the position of the rollers is vertically adjustable relative to the main support structure.

Abstract: A substantially 100% active aqueous solution of one or more phosphonocarboxylic acids and one or more hydroxides, wherein the solution has a slightly alkaline pH. In an alternate embodiment, a dry, free flowing mixture comprising one or more phosphonocarboxylic acids, calcium chloride fines which, on average, are a dihydrate, and hydroxide is disclosed.

Abstract: An expandable article mounting rack comprises at least one panel where each panel has a major planar surface with a plurality of laterally resiliently deformable clamping pillars extending therefrom and arranged in a matrix configuration defining orthogonal rows of clamping pillars between which a printed circuit board or other like article can be inserted and held. Each clamping pillar includes an upstanding member having a laterally resiliently deformable portion spaced from the top surface of the panel and a support portion interconnected to the top surface. The deformable portion is positioned so that when an article is positioned between adjacent rows of pillars, the deformable portion will be depressed laterally inwardly and will thus exert a pressing force against the edge of the article so positioned.

Abstract: This invention discloses oil purifying means suitable for installation in any gear assembly that includes a gear supported in a stationary housing for rotation about an axis and having a generally planar surface extending radially from the axis. The purifying means includes first means arranged during rotation of the gear, to direct a supply of lubricating oil onto the surface so that the oil is centrifuged outwardly and into second means forming an annular cavity adjacent the peripheral region of the gear. The cavity has an inwardly directed opening providing separate inlet and outlet fluid flow paths arrange so that, during rotation of the gear, lubricating oil is centrifuged through the inlet into the cavity wherein the direction of oil is reversed so that the oil exhausts through the outlet and contaminent particles in the oil are retained in the cavity due to centrifugal force.

Abstract: A cut pile fabric is produced using a grass-like fiber and, optionally, a crimped or crimpable fiber of lower denier than said grass-like fiber plied therewith. The pile fabric made from such fibers has improved aesthetics (e.g., appearance) and mechanical (e.g., frictional) properties, and closely simulates natural turf.