Abstract: Provided herein are novel CLDN6 binding domains, and anti-CLDN6×anti-CD3 antibodies that include such CLDN6 binding domains. Also provided herein are methods of using such antibodies for the treatment of CLDN6-associated cancers.

Abstract: Described herein are methods and computer systems for classification of CD8 T-cell topology using a patient response-based linear cutoff model. A plurality of histology images of tissue samples in a plurality of patients are received by a computer system. An image analysis of the plurality of histology images is performed to obtain a CD8+ T-cell abundance in the tumor parenchyma and stroma in each of the plurality of histology images. Real inflammation scores and tumor infiltration scores are determined based on a polar coordinate transformation of the CD8+ T-cell abundance in the tumor parenchyma and stroma. Based on the real inflammation scores and tumor infiltration scores, a feature space is generated, and linear boundaries or linear cutoffs between a plurality of classifications in the feature space are identified based on the real inflammation scores, the tumor infiltration scores, and patient response data.

Abstract: A secondary battery is provided for cycling between a charged and a discharged state, the secondary battery including a battery enclosure, an electrode assembly, carrier ions, a non-aqueous liquid electrolyte within the battery enclosure, and a set of electrode constraints. The set of electrode constraints includes a primary constraint system having first and second primary growth constraints and at least one primary connecting member, the first and second primary growth constraints separated from each other in the longitudinal direction, wherein the primary constraint array restrains growth of the electrode assembly in the longitudinal direction such that any increase in the Feret diameter of the electrode assembly in the longitudinal direction over 20 consecutive cycles of the secondary battery is less than 20%.

Abstract: The present invention is directed to novel heterodimeric antibodies.

Abstract: The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.

Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a dialog system using user feedback. According to one implementation, a method includes receiving, by a dialog engine and from a computing device, a voice input; determining, by the dialog engine, that the received voice input is classified as feedback to an answer of a question; identifying, by the dialog engine, a predetermined feedback score associated with the feedback; and adjusting a confidence score associated with the question and the answer based on the predetermined feedback score.

Abstract: Implementations relate to techniques for providing context-dependent search results. The techniques can include receiving a query and background audio. The techniques can also include identifying the background audio, establishing concepts related to the background audio and obtaining terms related to the concepts related to the background audio. The techniques can also include obtaining search results based on the query and on at least one of the terms. The techniques can also include providing the search results.

Abstract: Implementations relate to techniques for providing context-dependent search results. A computer-implemented method includes receiving an audio stream at a computing device during a time interval, the audio stream comprising user speech data and background audio, separating the audio stream into a first substream that includes the user speech data and a second substream that includes the background audio, identifying concepts related to the background audio, generating a set of terms related to the identified concepts, influencing a speech recognizer based on at least one of the terms related to the background audio, and obtaining a recognized version of the user speech data using the speech recognizer.

Abstract: Implementations relate to techniques for providing context-dependent search results. A computer-implemented method includes receiving an audio stream at a computing device during a time interval, the audio stream comprising user speech data and background audio, separating the audio stream into a first substream that includes the user speech data and a second substream that includes the background audio, identifying concepts related to the background audio, generating a set of terms related to the identified concepts, influencing a speech recognizer based on at least one of the terms related to the background audio, and obtaining a recognized version of the user speech data using the speech recognizer.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a dialog system using user feedback. According to one implementation, a method includes receiving, by a dialog engine and from a computing device, a voice input, determining, by the dialog engine, that the received voice input is classified as feedback to an answer of a question; identifying, by the dialog engine, a predetermined feedback scare associated with the feedback; and adjusting a confidence score associated with the question and the answer based on the predetermined feedback score.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a dialog system using user feedback. According to one implementation, a method includes receiving, by a dialog engine and from a computing device, a voice input; determining, by the dialog engine, that the received voice input is classified as feedback to an answer of a question; identifying by the dialog engine, a predetermined feedback score associated with the feedback; and adjusting a confidence score associated with the question and the answer based on the predetermined feedback score.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for training a dialog system using user feedback. According to one implementation, a method includes receiving, by a dialog engine and from a computing device, a voice input; determining, by the dialog engine, that the received voice input is classified as feedback to an answer of a question; identifying, by the dialog engine, a predetermined feedback score associated with the feedback; and adjusting a confidence score associated with the question and the answer based on the predetermined feedback score.

Abstract: A semi-aqueous method for extracting a substance. The method involves combining a first liquid or solid substance containing an extract with a semi-aqueous solution containing a water-soluble or water-emulsifiable (WSWE) compound. Said WSWE compound selectively dissolves extract during a dense phase CO2 expansion and salting-out process, which is simultaneously co-extracted using said dense phase CO2, and desolvated to produce a CO2 salted-out solvent mixture containing extract. Said CO2 salted-out solvent mixture is treated using various secondary processes. The present invention is useful for producing extracts for use as additives in pharmaceuticals, nutraceuticals, cosmetics, beverages, or foods, and for quantitative analysis.

Abstract: Implementations relate to techniques for providing context-dependent search results. The techniques can include receiving a query and background audio. The techniques can also include identifying the background audio, establishing concepts related to the background audio and obtaining terms related to the concepts related to the background audio. The techniques can also include obtaining search results based on the query and on at least one of the terms. The techniques can also include providing the search results.

Abstract: Implementations relate to techniques for providing context-dependent search results. A computer-implemented method includes receiving an audio stream at a computing device during a time interval, the audio stream comprising user speech data and background audio, separating the audio stream into a first substream that includes the user speech data and a second substream that includes the background audio, identifying concepts related to the background audio, generating a set of terms related to the identified concepts, influencing a speech recognizer based on at least one of the terms related to the background audio, and obtaining a recognized version of the user speech data using the speech recognizer.

Abstract: The invention is a method of predicting response to therapy in a colorectal cancer patient, the method comprising measuring tumor genetic heterogeneity via analysis of circulating tumor DNA from a patient's sample.

Abstract: Implementations relate to techniques for providing context-dependent search results. A computer-implemented method includes receiving an audio stream at a computing device during a time interval, the audio stream comprising user speech data and background audio, separating the audio stream into a first substream that includes the user speech data and a second substream that includes the background audio, identifying concepts related to the background audio, generating a set of terms related to the identified concepts, influencing a speech recognizer based on at least one of the terms related to the background audio, and obtaining a recognized version of the user speech data using the speech recognizer.

Abstract: This application presents a method and apparatus for cooling a through-ported cutting tool with a source of liquid CO2 with a compressed air line with a compressed air inlet and multiple CO2 injection capillary segments; the capillary segments interconnect to the same source of liquid CO2 and can have high pressure valves and throttles; the throttles have different sizes; a first capillary ends near the cutting tool; the second capillary ends near the compressed air inlet. Using a particular sequence of opening or closing the valves to the liquid CO2 to the capillaries, mixing with the compressed air provides and recycling the residual CO2, this invention provides for uniform and controlled cooling of the cutting tool within a certain temperature range.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for resolving ambiguity in received voice queries. An original voice query is received following one or more earlier voice queries, wherein the original voice query includes a pronoun or phrase. In one implementation, a plurality of acoustic parameters is identified for one or more words in the original voice query. A concept represented by the pronoun is identified based on the plurality of acoustic parameters, wherein the concept is associated with a particular query of the one or more earlier queries. The concept is associated with the pronoun. Alternatively, a concept may be associated with a phrase by using grammatical analysis of the query to relate the phrase to a concept derived from a prior query.