Abstract: An occlusion device includes a balloon and a catheter. The occlusion device is configured to allow blood to pass through the balloon, instead of around the balloon. By allowing the blood to pass through the balloon, constant traction against the vessel wall is achieved, regardless of flow rate, thereby mitigating distal migration. The balloon includes an orifice to allow blood flow through the balloon. The orifice is independent of the diameter of the vessel, therefore the effect of the diameter of the vessel changing during the procedure will not affect the flow rate of blood. The occlusion device enables finer titration of blood flow by varying the size of the orifice when compared to conventional solutions.

Abstract: A pump for pumping fluid includes a tube platen, a plunger, a bias member, inlet and outlet valves, an actuator mechanism, a position sensor, and a processor. The plunger is configured for actuation toward and away from the infusion-tube when the tube platen is disposed opposite to the plunger. The tube platen can hold an intravenous infusion tube. The bias member is configured to urge the plunger toward the tube platen.

Abstract: A vaporizer device includes various modular components. The vaporizer device includes a first subassembly. The first subassembly includes a cartridge connector that secures a vaporizer cartridge to the vaporizer device and includes at least two receptacle contacts that electrically communicate with the vaporizer cartridge. The vaporizer device includes a second subassembly. The second subassembly includes a skeleton defining a rigid tray that retains at least a power source. The vaporizer device also includes a third subassembly. The third subassembly includes a plurality of charging contacts that supply power to the power source, and an end cap that encloses an end of the vaporizer device.

Abstract: Disclosed herein are non-human animals (e.g., rodents, e.g., mice or rats) genetically engineered to express a humanized or human T cell receptor (TCR) comprising a variable domain encoded by (a) at least one human TCR variable region ? gene segment and a (human) TCR ? constant region gene sequence and/or (b) or at least one human TCR variable region ? gene segment and a (human) TCR ? constant region gene sequence. Also provided are embryos, tissues, and cells expressing the same. Methods for making a genetically engineered animal that expresses the humanized or human ? and/or ? TCR are also provided. Methods for using the genetically engineered animals that mount a substantially humanized T cell immune response for developing human therapeutics are also provided.

Abstract: Methods are provided herein for assembling at least two nucleic acids using a sequence specific nuclease agent (e.g., a gRNA-Cas complex) to create end sequences having complementarity and subsequently assembling the overlapping complementary sequences. The nuclease agent (e.g., a gRNA-Cas complex) can create double strand breaks in dsDNA in order to create overlapping end sequences or can create nicks on each strand to produce complementary overhanging end sequences. Assembly using the method described herein can assemble any nucleic acids having overlapping sequences or can use a joiner oligo to assemble sequences without complementary ends.

Abstract: Provided herein are methods and compositions related to mice that express human or humanized Foot receptors (FcaR) from an FcaR locus positioned in the mouse leukocyte receptor complex (LRC). In certain embodiments, such mice are useful for in vivo testing of therapeutic agents comprising a human IgA Fc (e.g., the testing of the pharmacokinetic and/or pharmacodynamic properties of such therapeutic agents and dosing regimens). Also provided herein are methods of using such mice, cells from such mice, methods of making such mice, and ES cells comprising the same genetic modifications as such mice. Provided herein are methods and compositions related to mice that express human or humanized Foot receptors (FcaR) from an FcaR locus positioned in the mouse leukocyte receptor complex (LRC). In certain embodiments, such mice are useful for in vivo testing of therapeutic agents comprising a human IgA Fc (e.g.

Abstract: Mice, embryos, cells, and tissues having a restricted immunoglobulin heavy chain locus and an ectopic sequence encoding one or more ADAM6 proteins are provided. In various embodiments, mice are described that have humanized endogenous immunoglobulin heavy chain loci and are capable of expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof that is functional in a male mouse. Mice, embryos, cells, and tissues having an immunoglobulin heavy chain locus characterized by a single human VH gene segment, a plurality of human DH gene segments and a plurality of human JH gene segments and capable expressing an ADAM6 protein or ortholog or homolog or functional fragment thereof are also provided.

Abstract: Signal egress from a shielding flaw in a cable telecommunication system is detected, even where signals carried by the cable telecommunication system are quadrature amplitude modulated signals that statistically resemble broadband noise by generating a marker signal comprising a double side band, suppressed carrier signal in the fringes of contiguous frequency bands and at a power level which cannot cause perceptible interference with signals in those contiguous frequency bands. The separation of the sidebands comprising the marker signal can unambiguously identify the marker signal and can distinguish between different cable telecommunication systems installed in the same geographic area. The marker signal can be additionally coded by varying the frequency and/or amplitude of the modulating signal used to create the marker signal.

Abstract: A small, portable signal generator provides a unique marker signal modulated with a selectable number of degrees of freedom for insertion into a portion of a broadband communication system (BCS) such as a subscriber installation site that may or may not be connected to the remainder of the BCS. If payload signals are not present or brief interference with payload signals is tolerable, a high level marker signal may be injected with level control upon detection of an egress signal to detect very minor leakage sources and thus increase quality of the qualification of installation or repairs. If payload signals are present, marker signals are held to non-interfering levels and frequencies. Authentication of a signal received through an antenna is expedited and increased in confidence level by synchronization of the marker signal modulation pattern and the signal detector in a receiver.

Abstract: A cyclic prefix which duplicates some samples of a terminal portion of a symbol in an OFDM data stream and which is invariant in pilot tones can be detected in the presence of signals having higher levels of noise and broadcast signals by autocorrelation with one of two selected “lags”. Autocorrelation will be found when the lag is equal to the number of samples in the FFT used to form a symbol in the data stream. A far stronger autocorrelation is found when the lag is equal to the sum of the FFT length and the length of the cyclic prefix and applied to pilots in the data stream. Overbuilt systems can be distinguished from a system of interest by use of pilots that do not coincide in frequency with a pilot of an overbuilt system.

Abstract: A small, portable signal generator provides a unique marker signal modulated with a selectable number of degrees of freedom for insertion into a portion of a broadband communication system (BCS) such as a subscriber installation site that may or may not be connected to the remainder of the BCS. If payload signals are not present or brief interference with payload signals is tolerable, a high level marker signal may be injected with level control upon detection of an egress signal to detect very minor leakage sources and thus increase quality of the qualification of installation or repairs. If payload signals are present, marker signals are held to non-interfering levels and frequencies. Authentication of a signal received through an antenna is expedited and increased in confidence level by synchronization of the marker signal modulation pattern and the signal detector in a receiver.

Abstract: The electronic Building Information Card (eBIC) system provides a systematic and comprehensive approach for building information maintenance to assist first responders and building owners in an emergency response. The eBIC solution is built to the essential elements for each building along with a cross vertical view of the building. This provides the first responder a quick size-up assessment, an easy to read graphic view format and further support emergency operations for each building.

Abstract: A cyclic prefix which duplicates some samples of a terminal portion of a symbol in an OFDM data stream and which is invariant in pilot tones can be detected in the presence of signals having higher levels of noise and broadcast signals by autocorrelation with one of two selected “lags”. Autocorrelation will be found when the lag is equal to the number of samples in the FFT used to form a symbol in the data stream. A far stronger autocorrelation is found when the lag is equal to the sum of the FFT length and the length of the cyclic prefix and applied to pilots in the data stream. Overbuilt systems can be distinguished from a system of interest by use of pilots that do not coincide in frequency with a pilot of an overbuilt system.

Abstract: Passive detection of a quadrature amplitude modulated (QAM) signal amid noise is achieved by detection of a spectral component of a detected signal that corresponds to a known QAM symbol rate in, for example, a QAM modulated broadband communication system (BCS). Improved authentication can be provided by simultaneously detecting symbol rate components in two or more QAM bands. No modification of a broadband communication system such as by including a marker signal is required and thus there is no requirement for dedication of a portion of the broadband communication system spectrum or problem of marker signal interference with BCS signals.

Abstract: The electronic Building Information Card (eBIC) system provides a systematic and comprehensive approach for building information maintenance to assist first responders and building owners in an emergency response. The eBIC solution is built to the essential elements for each building along with a cross vertical view of the building. This provides the first responder a quick size-up assessment, an easy to read graphic view format and further support emergency operations for each building.

Abstract: Signal egress from a shielding flaw in a cable telecommunication system is detected, even where signals carried by the cable telecommunication system are quadrature amplitude modulated signals that statistically resemble broadband noise by generating a marker signal comprising a double side band, suppressed carrier signal in the fringes of contiguous frequency bands and at a power level which cannot cause perceptible interference with signals in those contiguous frequency bands. The separation of the sidebands comprising the marker signal can unambiguously identify the marker signal and can distinguish between different cable telecommunication systems installed in the same geographic area. The marker signal can be additionally coded by varying the frequency and/or amplitude of the modulating signal used to create the marker signal.

Abstract: Signal egress from a shielding flaw in a cable telecommunication system is detected, even where signals carried by the cable telecommunication system are quadrature amplitude modulated signals that statistically resemble broadband noise by generating a marker signal comprising a double side band, suppressed carrier signal in the fringes of contiguous frequency bands and at a power level which cannot cause perceptible interference with signals in those contiguous frequency bands. The separation of the sidebands comprising the marker signal can unambiguously identify the marker signal and can distinguish between different cable telecommunication systems installed in the same geographic area. The marker signal can be additionally coded by varying the frequency and/or amplitude of the modulating signal used to create the marker signal.

Abstract: Methods of treating stuttering include treating people with gamma-aminobutyric acid (GABA) receptor modulators, including cyclopyrrolones. A second active agent may be used with GABA receptor modulators. Active enantiomers, active metabolites, and pharmaceutically acceptable salts of gamma-aminobutyric acid receptor modulators, including cyclopyrrolones, are acceptable components of the compositions. The cyclopyrrolone class of modulators includes pagoclone, suriclone, zopiclone, 2-(7-chloro-2-naphthyridin-1,8-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one, 2-(7-chloro-2-naphthyridin-1,8-yl)isoindolin-1-yl-4-acetamidobutyrate, and 2-(7-chloro-1,8-naphthyridin-2yl)-3-(5-methyl-5-hydroxy-2-oxohexyl)-1-isoindolinone.

Abstract: Passive detection of a quadrature amplitude modulated (QAM) signal amid noise is achieved by detection of a spectral component of a detected signal that corresponds to a known QAM symbol rate in, for example, a QAM modulated broadband communication system (BCS). Improved authentication can be provided by simultaneously detecting symbol rate components in two or more QAM bands. No modification of a broadband communication system such as by including a marker signal is required and thus there is no requirement for dedication of a portion of the broadband communication system spectrum or problem of marker signal interference with BCS signals.

Abstract: A pillbox comprising a plurality of compartments, each compartment having two side walls, two end walls, and a bottom and each compartment having a top, each top comprising a hinged lid for accessing the compartment, the hinged lid being hinged pivotally at a hinge area; a slot at one of the walls of each compartment disposed parallel to the one wall, further wherein the hinged lid for each compartment is separable from the compartment, each hinged lid having a tab depending from the hinged lid and being pivotable from the lid at the hinge area, the tab being insertable into the slot to secure the hinged lid to the compartment for access to the compartment, the tab being releasably and frictionally held in place in the slot and being removable from the slot integral with the lid when the lid is removed.