Patents by Inventor John J. Rajasekaran

John J. Rajasekaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190111404
    Abstract: Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N->C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
    Type: Application
    Filed: November 14, 2013
    Publication date: April 18, 2019
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Publication number: 20190030528
    Abstract: Disclosed herein are methods, tools, pillar plates, and tool assemblies for biomolecular analysis using microarrays that reduces the likelihood of air bubbles being trapped by the microarrays. Embodiments of the tools include two clamps that have a tool mount portion and a grasping portion. The tool mount portion is configured to engage a lifting mechanism of a plate handling robot for moving a pillar plate that include microarrays. The grasping portion is configured to freely suspend the pillar plate at an inclination of a non-zero tilt angle relative to a plane normal to the tool mount portion. Embodiments of pillar plates include two protruding edges on opposite sides of the pillar plate and a plurality of pillars with one or more affixed microarrays. Embodiments of the tool assembly include the tool and the pillar plate, wherein the protruding edges are configured to engage with the gasping portions.
    Type: Application
    Filed: October 25, 2016
    Publication date: January 31, 2019
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy, Karthik Krishna
  • Publication number: 20190018006
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: May 11, 2018
    Publication date: January 17, 2019
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Patent number: 10175234
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Grant
    Filed: July 21, 2016
    Date of Patent: January 8, 2019
    Assignee: Vibrant Holdings, LLC
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Patent number: 10006909
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Grant
    Filed: September 30, 2013
    Date of Patent: June 26, 2018
    Assignee: Vibrant Holdings, LLC
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Publication number: 20180106795
    Abstract: Disclosed herein are formulations, substrates, and arrays. In certain embodiments, methods of attaching a biomolecule to an array using a photoactivated conjugation compound are disclosed. Methods of generating site-specific attachment of biomolecules to an array are also disclosed. Arrays generated by these methods and methods of using these arrays are also disclosed.
    Type: Application
    Filed: March 14, 2016
    Publication date: April 19, 2018
    Inventors: John J. Rajasekaran, Tianhao Wang, Kang Bei, Vasanth Jayaraman, Hari Krishnan Krishnamurthy
  • Publication number: 20170269077
    Abstract: The present disclosure relates generally to biomarkers and peptide arrays, and, more particularly, to a method of using a peptide array to identify biomarkers for an autoimmune disease such as, e.g., celiac disease. Furthermore, a set of novel biomarkers for celiac disease, having high sensitivity and specificity, are disclosed in addition to method of treatment using the novel biomarkers.
    Type: Application
    Filed: September 10, 2015
    Publication date: September 21, 2017
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Kang Bei, Tianhao Wang, Karthik Krishna, Hari Krishnan Krishnamurthy
  • Publication number: 20170192007
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: February 17, 2014
    Publication date: July 6, 2017
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Patent number: 9499578
    Abstract: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
    Type: Grant
    Filed: June 4, 2008
    Date of Patent: November 22, 2016
    Assignee: Intel Corporation
    Inventors: John J. Rajasekaran, Edelmira Cabezas, Jacqueline A. Fidanza, Gunjan Tiwari
  • Publication number: 20160327552
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: July 21, 2016
    Publication date: November 10, 2016
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Publication number: 20160288080
    Abstract: Disclosed herein are formulations, substrates, and arrays. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays, including porous arrays. Also disclosed herein are formulations and methods for one-step coupling, e.g., for synthesis of peptides in an N->C orientation. In some embodiments, disclosed herein are formulations and methods for high efficiency coupling of biomolecules to a substrate.
    Type: Application
    Filed: November 14, 2013
    Publication date: October 6, 2016
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Patent number: 9417236
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Grant
    Filed: March 28, 2015
    Date of Patent: August 16, 2016
    Assignee: Vibrant Holdings, LLC
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Publication number: 20160067667
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: November 13, 2015
    Publication date: March 10, 2016
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Publication number: 20160003816
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: September 30, 2013
    Publication date: January 7, 2016
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Bei Kang, Hari Krishnan Krishnamurthy
  • Patent number: 9216399
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: December 22, 2015
    Assignee: VIBRANT HOLDINGS, LLC
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Publication number: 20150260712
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: March 28, 2015
    Publication date: September 17, 2015
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Bei Kang, Hari Krishnan Krishnamurthy
  • Patent number: 9096953
    Abstract: The embodiments of the invention relate to a system and method for making a biomolecule microarray comprising a spacer attachment module adapted to attach a linker to a substrate surface of the biomolecule microarray, a coupling module adapted to couple a molecule to the linker, the molecule being capable of forming a peptide bond and containing a protecting group that prevents the formation of the peptide bond, and a deprotection module adapted to create deprotection of the protecting group with a radiation exposure of about 1-50 mJ/cm2.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: August 4, 2015
    Assignee: INTEL CORPORATION
    Inventors: Narayan Sundararajan, John J. Rajasekaran, Guangyu Xu, Gunjan Tiwari, Edelmira Cabezas
  • Publication number: 20140349888
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Publication number: 20100240555
    Abstract: The embodiments of the invention relate to a system and method for making a biomolecule microarray comprising a spacer attachment module adapted to attach a linker to a substrate surface of the biomolecule microarray, a coupling module adapted to couple a molecule to the linker, the molecule being capable of forming a peptide bond and containing a protecting group that prevents the formation of the peptide bond, and a deprotection module adapted to create deprotection of the protecting group with a radiation exposure of about 1-50 mJ/cm2.
    Type: Application
    Filed: September 29, 2006
    Publication date: September 23, 2010
    Inventors: Narayan Sundararajan, John J. Rajasekaran, Guangyu Xu, Gunjan Tiwari, Edelmira Cabezas
  • Publication number: 20090258796
    Abstract: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
    Type: Application
    Filed: June 4, 2008
    Publication date: October 15, 2009
    Inventors: John J. Rajasekaran, Edelmira Cabezas, Jacqueline A. Fidanza, Gunjan Tiwari