Patents by Inventor John J. Rajasekaran

John J. Rajasekaran has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substrates, Peptide Arrays, and Methods
    Publication number: 20160067667
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: November 13, 2015
    Publication date: March 10, 2016
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Methods, Systems, and Arrays for Biomolecular Analysis
    Publication number: 20160003816
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: September 30, 2013
    Publication date: January 7, 2016
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Bei Kang, Hari Krishnan Krishnamurthy
  • Substrates, peptide arrays, and methods
    Patent number: 9216399
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Grant
    Filed: August 7, 2014
    Date of Patent: December 22, 2015
    Assignee: VIBRANT HOLDINGS, LLC
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Methods, Systems, and Arrays for Biomolecular Analysis
    Publication number: 20150260712
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: March 28, 2015
    Publication date: September 17, 2015
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Bei Kang, Hari Krishnan Krishnamurthy
  • Method for high throughput, high volume manufacturing of biomolecule micro arrays
    Patent number: 9096953
    Abstract: The embodiments of the invention relate to a system and method for making a biomolecule microarray comprising a spacer attachment module adapted to attach a linker to a substrate surface of the biomolecule microarray, a coupling module adapted to couple a molecule to the linker, the molecule being capable of forming a peptide bond and containing a protecting group that prevents the formation of the peptide bond, and a deprotection module adapted to create deprotection of the protecting group with a radiation exposure of about 1-50 mJ/cm2.
    Type: Grant
    Filed: September 29, 2006
    Date of Patent: August 4, 2015
    Assignee: INTEL CORPORATION
    Inventors: Narayan Sundararajan, John J. Rajasekaran, Guangyu Xu, Gunjan Tiwari, Edelmira Cabezas
  • Substrates, Peptide Arrays, and Methods
    Publication number: 20140349888
    Abstract: Disclosed herein are formulations, substrates, and arrays. Also disclosed herein are methods for manufacturing and using the formulations, substrates, and arrays. Also disclosed are methods for identifying peptide sequences useful for diagnosis and treatment of disorders, and methods for using the peptide sequences for diagnosis and treatment of disorders, e.g., celiac disorder. In certain embodiments, substrates and arrays comprise a porous layer for synthesis and attachment of polymers or biomolecules.
    Type: Application
    Filed: August 7, 2014
    Publication date: November 27, 2014
    Inventors: John J. Rajasekaran, Vasanth Jayaraman, Tianhao Wang, Kang Bei, Hari Krishnan Krishnamurthy
  • Method for high throughput, high volume manufacturing of biomolecule micro arrays
    Publication number: 20100240555
    Abstract: The embodiments of the invention relate to a system and method for making a biomolecule microarray comprising a spacer attachment module adapted to attach a linker to a substrate surface of the biomolecule microarray, a coupling module adapted to couple a molecule to the linker, the molecule being capable of forming a peptide bond and containing a protecting group that prevents the formation of the peptide bond, and a deprotection module adapted to create deprotection of the protecting group with a radiation exposure of about 1-50 mJ/cm2.
    Type: Application
    Filed: September 29, 2006
    Publication date: September 23, 2010
    Inventors: Narayan Sundararajan, John J. Rajasekaran, Guangyu Xu, Gunjan Tiwari, Edelmira Cabezas
  • MASSIVELY PARALLEL SYNTHESIS OF BIOPOLYMERIC ARRAYS
    Publication number: 20090258796
    Abstract: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
    Type: Application
    Filed: June 4, 2008
    Publication date: October 15, 2009
    Inventors: John J. Rajasekaran, Edelmira Cabezas, Jacqueline A. Fidanza, Gunjan Tiwari
  • MASSIVELY PARALLEL SYNTHESIS OF BIOPOLYMERIC ARRAYS
    Publication number: 20080318808
    Abstract: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
    Type: Application
    Filed: June 4, 2008
    Publication date: December 25, 2008
    Inventors: John J. Rajasekaran, Edelmira Cabezas, Jacqueline Fidanza, Gunjan Tiwari
  • MASSIVELY PARALLEL SYNTHESIS OF BIOPOLYMERIC ARRAYS
    Publication number: 20080242561
    Abstract: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived lithographic methods. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of branched peptides and polymers joined by peptide bonds may be fabricated in a highly multiplexed manner.
    Type: Application
    Filed: June 4, 2008
    Publication date: October 2, 2008
    Inventors: John J. Rajasekaran, Edelmira Cabezas, Jacqueline A. Fidanza, Gunjan Tiwari
  • Solid-phase mediated synthesis of molecular microarrays
    Publication number: 20080108149
    Abstract: Methods for fabricating dense arrays of polymeric molecules in a highly multiplexed manner are provided using semiconductor-processing-derived methods and electrochemically generated reagents. Advantageously, the methods are adaptable to the synthesis of a variety of polymeric compounds. For example, arrays of peptides, polymers joined by peptide bonds, nucleic acids, and polymers joined by phosphodiester bonds may be fabricated in a highly multiplexed manner.
    Type: Application
    Filed: October 23, 2006
    Publication date: May 8, 2008
    Inventors: Narayan Sundararajan, John J. Rajasekaran, Guangyu Xu