Abstract: The present disclosure relates generally to a polypeptide having mono-(2-hydroxyethyl) terephthalate hydrolase (MHETase) activity, more specifically to a polypeptide comprising an amino acid sequence that (i) has at least 70% sequence identity to SEQ ID NO:1 and (ii) differs from SEQ ID NO:1 by an amino acid substitution at one or more positions selected from the group consisting of positions that correspond to amino acid positions 156 to 396, 398 to 410 and 425 to 603 of SEQ ID NO:1.

Abstract: Devices, kits and methods described herein are be used at chronic injection site or in conjunction with an indwelling catheter or cannula. A book-like packaging, applicator and/or tensioning device with an opening and optional indicia to align the catheter or cannula to the opening may be used to apply a dressing to a subject. The packaging, applicator and/or tensioning device may apply and/or maintain a strain in an elastic dressing.

Abstract: A system for applying a coating composition is provided herein. The system includes a first high transfer efficiency applicator defining a first nozzle orifice and a second high transfer efficiency applicator defining a second nozzle orifice. The system further includes a reservoir. The system further includes a substrate defining a first target area and a second target area. The first high transfer efficiency applicator and the second high transfer efficiency applicator are configured to receive the coating composition from the reservoir and configured to expel the coating composition through the first nozzle orifice to the first target area of the substrate and to expel the coating composition through the second nozzle orifice to the second target area of the substrate.

Abstract: The present disclosure relates generally to a process for producing polymer fibers, typically polyacrylonitrile-based fibers, the properties of which are controlled by certain parameters of the process, such as the amount of jet stretch, the amount of wet stretch, and the amount of hot stretch employed. The present disclosure also relates to a process for producing carbon fiber from such polymer fibers.

Abstract: The present disclosure relates to a filter apparatus (1) for mechanically filtering a liquid (W). The filter apparatus (1) includes a filter chamber (5) for containing a plurality of filter elements (7) that form a filter pack (29) for filtering the liquid. The filter chamber (5) has a liquid inlet (12) and a liquid outlet (14). The filter apparatus (1) includes means for introducing air into the filter chamber (5) through one or more air inlets (25) to agitate the filter elements (7). The filter chamber (5) is substantially sealed and the air introducing means (22) may be configured to draw air into the filter chamber (5) as liquid is drained from said filter chamber (5). In certain embodiments, the filter chamber (5) may have a substantially constant profile or a substantially continuously tapered profile along its longitudinal axis (X-X). The present disclosure also relates to methods of filtering a liquid (W).

Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.

Abstract: Systems and methods for magnitude and phase trimming are provided. In one aspect, a radio frequency (RF) trimmer circuit includes an input terminal configured to receive an RF signal, an output terminal configured to output the RF signal, a control input configured to receive a control signal, at least one impedance element, and at least one transistor configured to selectively connect the impedance element onto a path between the input and output terminals. The selectively connecting the impedance element controls at least one of a magnitude trim and a phase trim of the RF signal.

Abstract: A system for applying a first coating composition and a second coating composition is provided herein. The system includes an atomizing applicator and a high transfer efficiency applicator defining a nozzle orifice. The system further includes a substrate assembly comprising a metal-containing substrate and a plastic-containing substrate. The metal-containing substrate is coupled to the plastic-containing substrate. The atomizing applicator is configured to apply the first coating composition to the metal-containing substrate. The high transfer efficiency applicator is configured to expel the second coating composition through the second nozzle orifice to the plastic-containing substrate.

Abstract: Pre-connected analyte sensors are provided. A pre-connected analyte sensor includes a sensor carrier attached to an analyte sensor. The sensor carrier includes a substrate configured for mechanical coupling of the sensor to testing, calibration, or wearable equipment. The sensor carrier also includes conductive contacts for electrically coupling sensor electrodes to the testing, calibration, or wearable equipment.

Abstract: A fluid heating element includes first and second conduits. The first conduit has a first inlet and a first outlet. The first inlet is configured to receive a first portion of the fluid, and the first outlet is configured to discharge the first portion of the fluid. The second conduit has a second inlet and a second outlet. The second inlet is configured to receive a second portion of the fluid, and the second outlet is configured to discharge the second portion of the fluid. The fluid heating element further includes an electrothermal coating associated with the first and second conduits and an electrical lead configured to apply an electric current across the electrothermal coating. The electrothermal coating converts the electric current to heat that is transferred to through the first and second conduits to the fluid.

Abstract: The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody. In some embodiments, the method further comprises identifying the patient as having a LAG-3 positive PD-L1 positive tumor. In some embodiments, the LAG-3 inhibitor is an anti-LAG-3 antibody and the PD-1 pathway inhibitor is an anti-PD-1 antibody. The methods of the invention can improve response rates to treatment with a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, or a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor.

Abstract: The present disclosure provides an aerosol generating component containing a substrate carrying at least one aerosol forming material. The substrate is substantially free of solid tobacco material, and includes about 60% dry weight or more of one or more fillers, based on the total dry weight of the substrate, and at least one binder. The final form of the substrate can be configured to be used in aerosol generating components for aerosol delivery devices. Such devices utilize electrically generated heat or combustible ignition sources to heat the aerosol forming materials, providing an inhalable substance in the form of an aerosol.

Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.

Abstract: Reusable instrumentation, such as a medical instrument or tool, is decontaminated by applying pressure waves from multiple shockwave applicators and/or reflectors.

Abstract: A system for blast hole data collection for use in a mine site incorporates an instrument configured to acquire geological property data of a blast hole for processing in the system or remotely and a vehicle having a handling system configured to move the instrument into and out of the blast hole as an interchangeable element with a drill string or prior to explosives charging and charging the blast hole in accordance with a determined charge profile.

Abstract: Systems and methods for magnitude and phase trimming are provided. In one aspect, a radio frequency (RF) trimmer circuit includes an input terminal configured to receive an RF signal, an output terminal configured to output the RF signal, a control input configured to receive a control signal, at least one impedance element, and at least one transistor configured to selectively connect the impedance element onto a path between the input and output terminals. The selectively connecting the impedance element controls at least one of a magnitude trim and a phase trim of the RF signal.

Abstract: A reusable apparatus, such as a medical instrument or tool, is decontaminated by applying pressure waves with direct contact of the pressure wave applicator to the reusable apparatus in an open bath in a sufficient dosage to remove contamination but without adversely affecting the ability to reuse the apparatus.

Abstract: Systems, methods, and computer-readable media are disclosed for a systems and methods for improved LIDAR return light capture efficiency. One example method may include comparing, by a controller including a processor and at a first time, a first temperature of a first computing element to a first threshold temperature and a second temperature of a second computing element to a second threshold temperature. The example method may also include sending, based on a determination that the first temperature is below the first threshold temperature and the second temperature is above the second threshold temperature, a first signal to a switch to activate a data output corresponding to the second computing element. The example method may also include sending, to the second computing element, a second signal to cause a third computing element to increase heat dissipation from the third computing element to the first computing element.

Abstract: A system for blast hole data collection for use in a mine site incorporates an instrument configured to acquire geological property data of a blast hole for processing in the system or remotely and a vehicle having a handling system configured to move the instrument into and out of the blast hole as an interchangeable element with a drill string or prior to explosives charging.

Abstract: A reusable apparatus, such as a medical instrument or tool, is decontaminated by applying pressure waves with direct contact of the pressure wave applicator to the reusable apparatus in an open bath in a sufficient dosage to remove contamination but without adversely affecting the ability to reuse the apparatus.