Abstract: The invention features a mucosal coating composition including: (i) water: (ii) at least one mucoadhesive polymer/polysaccharide (e.g., a concentration between 0.1-20% w/v); and (iii) at least one surfactant (e.g., a concentration between 0.005-5% w/v). Exhibit long-lasting residence times on mucosal tissues and prophylactic protection against transmucosal pathogens.

Abstract: A turbine airfoil comprises an airfoil defining a leading edge, a trailing edge, a root portion, a tip portion, a chord line defining a chord length of the airfoil, a suction side surface extending in a spanwise direction from the root portion to the tip portion and in a flow-wise direction between the leading edge and the trailing edge, and a throat line extending spanwise along the suction side surface from the root portion to the tip portion. The turbine airfoil further includes a plurality of micro-riblet patches defined along the suction side surface aft of the throat line where each micro-riblet patch of the plurality of micro-riblet patches extends in the flow-wise direction between the throat line and the trailing edge.

Abstract: Aerodynamically mistuned airfoils for unsteady loss reductions are disclosed herein. An example apparatus disclosed herein includes a disk, a first airfoil coupled to the disk, the first airfoil having a first geometry, and a second airfoil coupled to the disk adjacent to the first airfoil, the second airfoil having a second geometry different than the first geometry, the first airfoil and the second airfoil produce non-uniform wake passing times during operation of the disk.

Abstract: Techniques and apparatuses are described for overcoming memory, bandwidth, and/or power constraints in a processing-in-memory architecture. In example aspects, a memory device includes a logic circuit that is coupled to at least two banks. The memory device receives commands for concurrently performing at least a portion of a page operation and at least a portion of a processing-in-memory computation. The processing-in-memory computation is performed using the logic circuit and using data that was previously read from one of the active banks. The page operation is performed on another one of the banks that is idle to enable the logic circuit to access the data within this other bank for a later processing-in-memory computation. By performing the page operation during a same time as the processing-in-memory computation, a latency associated with the page operation can be effectively masked, thereby improving an overall efficiency of the memory device.

Abstract: Embodiments include formulations for topical administration of sugar alcohol to treat a skin condition such as athlete's foot, a yeast infection, jock itch (Tinea cruris), a toe nail infection, diaper rash, diaper candidiasis, ringworm (Tinea capitis), impetigo, erythrasma, pitted keratolysis, trichomycosis and sphingomonas paucimobilis. The formulation can include a moisturizer, an emollient, a sugar alcohol and zinc. In aspects, the sugar alcohol is erythritol with zinc chloride at a molar ratio of about 3:1. Embodiments also include erythritol-zinc antimicrobial coatings for personal use products.

Abstract: Aerodynamically mistuned airfoils for unsteady loss reductions are disclosed herein. An example apparatus disclosed herein includes a disk, a first airfoil coupled to the disk, the first airfoil having a first geometry, and a second airfoil coupled to the disk adjacent to the first airfoil, the second airfoil having a second geometry different than the first geometry, the first airfoil and the second airfoil produce non-uniform wake passing times during operation of the disk.

Abstract: A strap assembly for cable and cord management in sterile environments is provided. The assembly includes a strap and a fastener. The fastener and relatively flat strap are characterized by a minimum of bacteria harboring surface features, and are made from easily sanitizable materials. The strap is discretely adjustable lengthwise via a plurality of apertures formed therein. A first group of apertures are used to attach to the cord and a second group of apertures allows for positioning the strap about a cord bundle, the fastener interacting with said apertures to secure the strap to the bundle. Necessary surface features on the strap such as indicia are limited to a predetermined height to ensure that a single pass with a sanitizing wipe can effect bacterial and viral decontamination.

Abstract: Botulism is a potentially fatal illness caused by a toxin produced by the bacterium Clostridium botulinum. There are seven main types of botulinum toxin but the most common is type A (BoNT/A). There are few treatments for botulism which are often limited to supportive efforts. Embodiments include methods of treating botulism using Type E Botulinum toxin (BoNT/E). Intravenous administration allows administration of large doses of BoNT/E to systemically treat the disease and improve recovery times.

Abstract: Aerodynamically mistuned airfoils for unsteady loss reductions are disclosed herein. An example apparatus disclosed herein includes a disk, a first airfoil coupled to the disk, the first airfoil having a first geometry, and a second airfoil coupled to the disk adjacent to the first airfoil, the second airfoil having a second geometry different than the first geometry, the first airfoil and the second airfoil produce non-uniform wake passing times during operation of the disk.

Abstract: Embodiments include formulations for topical administration of sugar alcohol to treat a skin condition such as acne. A formulation can include a moisturizer, an emollient, a sugar alcohol and zinc. In aspects, the sugar alcohol is erythritol with zinc chloride at a molar ratio of about 3:1. Embodiments also include methods of administering the erythritol-zinc formulations. The methods can include microdermabrasion. In aspects, the erythritol-zinc formulation is applied to an area of skin after steps of (a) crystal-free microdermabrasion and (b) suction massage/cleansing.

Abstract: Detectors and related systems and methods for automatically detecting made and missed basketball shots using ultrasonics are provided. A launcher is connected to a structural subassembly and passes basketballs to locations about a basketball playing area having a basketball goal. A detector having at least one ultrasonic sensor is selectively positioned below and adjacent to a rim of the basketball goal and transmits bursts of ultrasonic signals. A processor monitors for reflections of the transmitted bursts occurring within a specified time period after transmission excluding an initial time period and time after the specified time period, and records a made shot where reflections of the transmitted bursts are detected within the specified time period. An accelerometer may optionally be included for determining if the made shot was a swish.

Abstract: An improved gripping member for a weight bearing container. The gripping member is specifically designed to either replace an existing gripping member, or improve a two part handle for a weight bearing container by providing a larger diameter gripping surface. The improved gripping member is formed of two identical mating halves that can be releasably attached to form a cylindrical gripping surface with a relatively large diameter. When attached about an existing gripping member or wire handle portion of a two part handle the inventive gripping member provides a large diameter gripping surface to distribute the weight of the container about a larger portion of the user's palm.

Abstract: Embodiments include formulations and methods for topical administration of sugar alcohol to treat a skin condition such as acne. A formulation can include a moisturizer, an emollient, a sugar alcohol and zinc. The sugar alcohol can be erythritol. The erythritol can be administered with zinc chloride. The erythritol and zinc chloride can be formulated at a molar ratio of about 3:1. The methods can also include administration of a therapeutic amount of a second agent such as benzoyl peroxide or a retinoid. Embodiments also include antimicrobial coatings that contain erythritol and zinc to reduce, negate, and prevent the proliferation and propagation of accumulating biofilm. The formulation can be used to clean and/or provide an antimicrobial coating on a medical device such as a catheter.

Abstract: Embodiments include formulations and methods for topical administration of sugar alcohol to treat a skin condition such as acne. A formulation can include a moisturizer, an emollient, a sugar alcohol and zinc. The sugar alcohol can be erythritol. The erythritol can be administered with zinc chloride. The erythritol and zinc chloride can be formulated at a molar ratio of about 3:1. The methods can also include administration of a therapeutic amount of a second agent such as benzoyl peroxide or a retinoid.

Abstract: Collagenase Clostridium Histolyticum (EN3835) is a proteinase that can hydrolyze the triple-helical region of collagen under physiological conditions. EN3835 targets the collagenase structural matrix at the site of injection and does not require systemic exposure. Embodiments include methods of lysing subdermal and submucosal collagen to treat various conditions such as bladder dysfunction, esophageal stenosis, benign prostatic hyperplasia, tracheal stenosis, subglottic stenosis and scleroderma.

Abstract: An improved gripping member for a weight bearing container. The gripping member is specifically designed to either replace an existing gripping member, or improve a two part handle for a weight bearing container by providing a larger diameter gripping surface. The improved gripping member is formed of two identical mating halves that can be releasably attached to form a cylindrical gripping surface with a relatively large diameter. When attached about an existing gripping member or wire handle portion of a two part handle the inventive gripping member provides a large diameter gripping surface to distribute the weight of the container about a larger portion of the user's palm.

Abstract: An apparatus and method for diffusing an airflow in a turbine engine can include a turbine center frame positioned between a high pressure turbine and a low pressure turbine of a turbine section of the engine. The turbine center frame can include two or more diffusion sections for diffusing the airflow. A stabilization section can be provided between the two or more diffusion sections to stabilize the airflow.

Abstract: The present invention provides, among other aspects, methods and compositions for treating Hearing Loss, including Sudden Sensorineural Healing Loss in a subject in need thereof, the method comprising: administering a therapeutically effective amount of a composition comprising human intravenous immunoglobulin (IVIG) to a subject. The present invention also provides, methods and composition for treating Hearing Loss, including Sudden Sensorineural Healing Loss in a subject in need thereof, the method comprising: administering a therapeutically effective amount of a composition comprising human IVIG and a steroid. In certain aspects of the present invention the steroid is a cortical steroid, including prednisone or methylprednisone.

Abstract: Collagenase Clostridium histolyticum (EN3835) is a proteinase that can hydrolyze the triple-helical region of collagen under physiological conditions. EN3835 targets the collagenase structural matrix at the site of injection and does not require systemic exposure. Embodiments include methods of lysing subdermal and submucosal collagen to treat various conditions such as bladder dysfunction, esophageal stenosis, benign prostatic hyperplasia, tracheal stenosis, subglottic stenosis and scleroderma.