Patents by Inventor John K. Thottathil

John K. Thottathil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel Alpha-Hydroxy Carboxylic Acid and Derivatives and Other GRAS Based Prodrugs of Oxycodone and Uses thereof
    Publication number: 20170152266
    Abstract: The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxycodone, in a manner that substantially decreases or deters the potential for opioid abuse, addiction, illicit and illegal use, and overdose. When delivered at the proper dosage, the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent.
    Type: Application
    Filed: November 29, 2015
    Publication date: June 1, 2017
    Inventor: John K. Thottathil
  • TAXANE COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20160376284
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: February 5, 2016
    Publication date: December 29, 2016
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Taxane compounds, compositions and methods
    Patent number: 9434740
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Grant
    Filed: July 8, 2014
    Date of Patent: September 6, 2016
    Assignee: ODONATE THERAPEUTICS, LLC
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Taxane compounds, compositions and methods
    Patent number: 9284327
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Grant
    Filed: March 6, 2014
    Date of Patent: March 15, 2016
    Assignee: GFV, LLC
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Gallium Complexes, Pharmaceutical Compositions and Methods of Use
    Publication number: 20150175631
    Abstract: The present invention provides complexes of gallium with a ligand, methods of making the complexes, methods of using the complexes and pharmaceutical gallium compositions comprising the complexes, in particular those compositions suitable for therapeutic oral administration.
    Type: Application
    Filed: January 26, 2015
    Publication date: June 25, 2015
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Taxane Compounds, Compositions and Methods
    Publication number: 20150080578
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: July 8, 2014
    Publication date: March 19, 2015
    Inventors: John K. Thottathil, Raymond P. Warrell
  • TAXANE COMPOUNDS, COMPOSITIONS AND METHODS
    Publication number: 20140249186
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: March 6, 2014
    Publication date: September 4, 2014
    Applicant: GFV, LLC
    Inventors: JOHN K. THOTTATHIL, RAYMOND P. WARRELL
  • Taxane compounds, compositions and methods
    Patent number: 8785669
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Grant
    Filed: June 28, 2011
    Date of Patent: July 22, 2014
    Assignee: GFV, LLC
    Inventors: John K. Thottathil, Raymond P. Warrell, Jr.
  • Taxane compounds, compositions and methods
    Patent number: 8697892
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: April 15, 2014
    Assignee: GFV, LLC
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Gallium Complexes, Pharmaceutical Compositions And Methods Of Use
    Publication number: 20120245135
    Abstract: The present invention provides complexes of gallium with a ligand, methods of making the complexes, methods of using the complexes and pharmaceutical gallium compositions comprising the complexes, in particular those compositions suitable for therapeutic oral administration.
    Type: Application
    Filed: March 22, 2012
    Publication date: September 27, 2012
    Applicant: Genta Incorporated
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Taxane Compounds, Compositions And Methods
    Publication number: 20120220634
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: April 25, 2012
    Publication date: August 30, 2012
    Applicant: Genta Incorporated
    Inventors: John K. Thottathil, Raymond P. Warrell
  • Taxane Compounds, Compositions And Methods
    Publication number: 20120004429
    Abstract: The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
    Type: Application
    Filed: June 28, 2011
    Publication date: January 5, 2012
    Applicant: Genta Incorporated
    Inventors: John K. Thottathil, Raymond P. Warrell, JR.
  • ?-Lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 7176326
    Abstract: Novel ?-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling ?-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: February 13, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • Methods for the preparation of taxanes using oxazolidine intermediates
    Patent number: 6784304
    Abstract: Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.
    Type: Grant
    Filed: December 11, 2001
    Date of Patent: August 31, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich
  • Methods for the preparation of biphenyl isoxazole sulfonamides
    Publication number: 20040059123
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
    Type: Application
    Filed: August 12, 2003
    Publication date: March 25, 2004
    Inventors: Richard P. Polniaszek, Xuebao Wang, John K. Thottathil, Theodor Denzel
  • Methods for the preparation of biphenyl isoxazole sulfonamides
    Patent number: 6639082
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: October 28, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Richard P. Polniaszek, Xuebao Wang, John K. Thottathil, Theodor Denzel
  • Novel methods for the preparation of taxanes using oxazolidine intermediates
    Publication number: 20020161238
    Abstract: Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.
    Type: Application
    Filed: December 11, 2001
    Publication date: October 31, 2002
    Inventors: John K. Thottathil, Ivan D. Trifunovich
  • Novel beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Publication number: 20020137927
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Application
    Filed: December 5, 2001
    Publication date: September 26, 2002
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • Phosphonooxymethyl ethers of taxane derivatives
    Patent number: 6455575
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: September 24, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, Dolatrai Vyas, John J. Wright, Henry Wong, John F. Kadow, John K. Thottathil, Wen-Sen Li, Murray A. Kaplan, Robert K. Perrone, Mark D. Wittman
  • Methods for the preparation of biphenyl isoxazole sulfonamides
    Publication number: 20020132838
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension.
    Type: Application
    Filed: September 28, 2001
    Publication date: September 19, 2002
    Inventors: Richard P. Polniaszek, Xuebao Wang, John K. Thottathil, Theodor Denzel