Patents by Inventor John K. Thottathil

John K. Thottathil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for the preparation of taxanes using oxazolidine intermediates
    Patent number: 6365750
    Abstract: Novel oxazolidines finding utility as intermediates in the preparation of C-13 acyloxy sidechain-bearing taxanes such as paclitaxel and analogs thereof. The present invention also relates to novel methods of coupling the oxazolidines to form the aforementioned taxanes, and to methods of preparing the oxazolidines.
    Type: Grant
    Filed: May 20, 1999
    Date of Patent: April 2, 2002
    Assignee: Bristol Myers Squibb Comp.
    Inventors: John K. Thottathil, Ivan D. Trifunovich
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6350886
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: February 26, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6350887
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: February 26, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • Methods for the preparation of biphenyl isoxazole sulfonamides
    Patent number: 6313308
    Abstract: Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates therof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension, congestive heart failure and male erectile dysfunction.
    Type: Grant
    Filed: March 20, 2000
    Date of Patent: November 6, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ambarish Singh, Chien-Kuang Chen, John A. Grosso, Edward J. Delaney, Xuebao Wang, Richard P. Polniaszek, John K. Thottathil
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6310201
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxes such as tall and tall derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxes, and to novel sidechain-bearing taxes.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: October 30, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • PHOSPHONOOXYMETHYL ETHERS OF TAXANE DERIVATIVES
    Publication number: 20010023255
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Application
    Filed: June 6, 1997
    Publication date: September 20, 2001
    Inventors: JERZY GOLIK, DOLATRAI VYAS, JOHN J. WRIGHT, HENRY WONG, JOHN F. KADOW, JOHN K. THOTTATHIL, WEN-SEN LI, MURRAY A. KAPLAN, ROBERT K. PERRONE, MARK D. WITTMAN
  • Preparation of 3-fluoro oxindole derivatives
    Patent number: 5892106
    Abstract: The present invention relates to novel intermediates of the formula ##STR1## wherein the wavy bond () represents the racemate, the (R)-enantiomer or the (S)-enantiomer; and R is hydrogen, a carboxyl-protecting group or a cation of an addition salt; or solvate thereof; and to the use thereof in a process for the preparation of certain 3-fluoro oxindole derivatives.
    Type: Grant
    Filed: June 18, 1998
    Date of Patent: April 6, 1999
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yadagiri R. Pendri, Eduardo J. Martinez, John K. Thottathil, Piyasena Hewawasam
  • Preparation of optically active (S)-(-) and (R)-(+)-deoxyspergualin and novel intermediates thereof
    Patent number: 5869734
    Abstract: A process for preparing optically active (S)-(-) and (R)-(+)-deoxyspergualin and salts thereof of the formula I ##STR1## by reacting a compound of formula II ##STR2## with a compound of formula III ##STR3## in the presence of a condensing/dehydrating agent and an organic or inorganic base in an organic solvent to form a compound of formula IV ##STR4## which can then be converted to the desired final product of formula I via deprotection and hydrogenolysis.
    Type: Grant
    Filed: September 23, 1996
    Date of Patent: February 9, 1999
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Xuebao Wang, John K. Thottathil
  • Reduction and resolution methods for the preparation of compounds useful as intermediates for preparing taxanes
    Patent number: 5817867
    Abstract: Reduction and resolution methods for the preparation of compounds useful as intermediates in the preparation of taxanes, and particularly for preparation of desired stereoisomers for use in the formation of the C-13 sidechain of pharmaceutically useful taxanes such as paclitaxel.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: October 6, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Wen-Sen Li, John K. Thottathil
  • Preparation of 3-fluoro oxindole derivatives
    Patent number: 5808095
    Abstract: The present invention relates to novel intermediates of the formula ##STR1## wherein the wavy bond () represents the racemate, the (R)-enantiomer or the (S)-enantiomer; and R is hydrogen, a carboxyl-protecting group or a cation of an addition salt; or solvate thereof; and to the use thereof in a process for the preparation of certain 3-fluoro oxindole derivatives.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: September 15, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Yadagiri R. Pendri, Eduardo J. Martinez, John K. Thottathil, Piyasena Hewawasam
  • Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
    Patent number: 5686298
    Abstract: An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.
    Type: Grant
    Filed: February 1, 1995
    Date of Patent: November 11, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Amit Banerjee, Clyde G. McNamee, John K. Thottathil, Laszlo J. Szarka
  • Phosphonooxymethyl ethers of taxane derivatives
    Patent number: 5646176
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Grant
    Filed: May 19, 1995
    Date of Patent: July 8, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, Dolatrai Vyas, John J. Wright, Henry Wong, John F. Kadow, John K. Thottathil, Wen-Sen Li, Murray A. Kaplan, Robert K. Perrone, Mark D. Wittman
  • 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same
    Patent number: 5618946
    Abstract: The present invention relates to novel 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates which may be used to prepare a final anti-thrombotic, anti-vasospastic product, and to methods for preparing the same.
    Type: Grant
    Filed: February 29, 1996
    Date of Patent: April 8, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
  • Reduction and resolution methods for the preparation of compounds useful as intemediates for preparing taxanes
    Patent number: 5602272
    Abstract: Reduction and resolution methods for the preparation of compounds useful as intermediates in the preparation of taxanes, and particularly for preparation of desired stereoisomers for use in the formation of the C-13 sidechain of pharmaceutically useful taxanes such as paclitaxel.
    Type: Grant
    Filed: June 21, 1994
    Date of Patent: February 11, 1997
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wen-Sen Li, John K. Thottathil
  • Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
    Patent number: 5594153
    Abstract: A novel, overall process for the preparation of a compound of the formula I: ##STR1## where R.sup.1 and R.sup.2 are each independently hydrogen, an alkyl group, a cycloalkyl group, an aryl group or, taken together with the carbon atom to which they are attached, form a cycloalkyl group; andR.sup.3 is hydrogen, an alkyl group, or an aryl group, or salts thereof, useful as intermediates in the preparation of HMG-CoA reductase inhibitors; novel methods within the overall process; and novel intermediates produced by those methods.
    Type: Grant
    Filed: July 5, 1995
    Date of Patent: January 14, 1997
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John K. Thottathil, Yadagiri Pendri, Wen-Sen Li, David R. Kronenthal
  • 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-basopastic compounds and method for preparing same
    Patent number: 5512690
    Abstract: A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
    Type: Grant
    Filed: September 14, 1995
    Date of Patent: April 30, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
  • 7-oxabicycloheptane carboxylic acid protaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same
    Patent number: 5508445
    Abstract: A method is provided for preparing carboxylic acid intermediates of the structure ##STR1##
    Type: Grant
    Filed: December 15, 1994
    Date of Patent: April 16, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael A. Poss, Paul D. Pansegrau, Shaopeng Wang, John K. Thottathil, Janak Singh, Richard H. Mueller
  • Process for preparing N-protected amino acid .alpha.-halomethyl ketones and alcohols from N-protected amino acid esters
    Patent number: 5481011
    Abstract: The present invention relates to a novel method useful for the conversion of amino acids to halomethylketones, which are then converted to amino acid epoxides. Such epoxides are important intermediates for the synthesis of inhibitors of renin and HIV protease, which are particularly useful in the treatment and/or prevention of HIV infection (AIDS).
    Type: Grant
    Filed: December 13, 1994
    Date of Patent: January 2, 1996
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ping Chen, Peter T. W. Cheng, Steven H. Spergel, Joel C. Barrish, John K. Thottathil, Robert Zahler, Richard P. Polniaszek, Xuebao Wang
  • Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-CoA reductase inhibitors
    Patent number: 5457227
    Abstract: A novel, overall process for the preparation of a compound of the formula I: ##STR1## where R.sup.1 and R.sup.2 are each independently hydrogen, an alkyl group, a cycloalkyl group, an aryl group or, taken together with the carbon atom to which they are attached, form a cycloalkyl group; andR.sup.3 is hydrogen, an alkyl group, or an aryl group, or salts thereof, useful as intermediates in the preparation of HMG-CoA reductase inhibitors; novel methods within the overall process; and novel intermediates produced by those methods.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: October 10, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: John K. Thottathil, Yadagiri Pendri, Wen-Sen Li, David R. Kronenthal
  • Enzymatic reduction method for the preparation of compounds useful for preparing taxanes
    Patent number: 5420337
    Abstract: An enzymatic reduction method, particularly a stereoselective enzymatic reduction method, for the preparation of compounds useful as intermediates in the preparation of taxanes.
    Type: Grant
    Filed: November 12, 1992
    Date of Patent: May 30, 1995
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Ramesh N. Patel, Amit Banerjee, Clyde G. McNamee, John K. Thottathil, Laszlo J. Szarka