Patents by Inventor John Kuriyan

John Kuriyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of the EGFR kinase targeting the asymmetric activating dimer interface
    Patent number: 8242080
    Abstract: The invention provides methods and compositions for the modulation of EGFR activity. In particular, inhibition of EGFR activation through an allosteric mechanism is discloses, as is a method for targeted drug discovery and design based on models of the three dimensional structure of the kinase domains of the protein dimers.
    Type: Grant
    Filed: October 15, 2007
    Date of Patent: August 14, 2012
    Assignee: The Regents of the University of California
    Inventors: John Kuriyan, Xuewu Zhang, Philip Cole
  • NOVEL ASSAY FOR INHIBITORS OF EGFR
    Publication number: 20100323957
    Abstract: The invention provides methods and compositions for screening for modulators of EGFR activity. In particular, an assay for such modulators is provided, which includes methods of screening for modulators using models of the three dimensional structure of EGFR kinase domains.
    Type: Application
    Filed: November 19, 2008
    Publication date: December 23, 2010
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA THE OFFICE OF THE PRESIDENT
    Inventors: John Kuriyan, Xuewu Zhang, Natalia Jura
  • Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof
    Patent number: 7803596
    Abstract: A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus, and corresponds to Polymerase III in E. coli. The genes and the polypeptides corresponding to T.th. ?, ?, ?, ? and ? subunits that they encode are disclosed, as are probes, vectors, methods of preparation and the methods of use. The enzymes of the present invention and their components are particularly well suited for use in procedures for the preparation of DNA, such as PCR, because of the speed and accuracy that they are able to achieve.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: September 28, 2010
    Assignee: The Rockefeller University
    Inventors: Olga Yurieva, John Kuriyan, Michael E. O'Donnell, David Jeruzalmi
  • NOVEL INHIBITORS OF THE EGFR KINASE TARGETING THE ASYMMETRIC ACTIVATING DIMER INTERFACE
    Publication number: 20100120678
    Abstract: The invention provides methods and compositions for the modulation of EGFR activity, in particular, inhibition of EGFR activation through an allosteric mechanism is discloses, as is a method for targeted drug discovery and design based on models of the three dimensional structure of the kinase domains of the protein dimers.
    Type: Application
    Filed: October 15, 2007
    Publication date: May 13, 2010
    Applicant: The Regents of the University of California The Office of the President
    Inventors: John Kuriyan, Xuewu Zhang, Philip Cole
  • ENZYME DERIVED FROM THERMOPHILIC ORGANISMS THAT FUNCTIONS AS A CHROMOSOMAL REPLICASE, AND PREPARATION AND USES THEREOF
    Publication number: 20100003720
    Abstract: A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus, and corresponds to Polymerase III in E. coli. The genes and the polypeptides corresponding to T.th. ?, ?, ?, ? and ? subunits that they encode are disclosed, as are probes, vectors, methods of preparation and the methods of use. The enzymes of the present invention and their components are particularly well suited for use in procedures for the preparation of DNA, such as PCR, because of the speed and accuracy that they are able to achieve.
    Type: Application
    Filed: June 4, 2009
    Publication date: January 7, 2010
    Applicant: THE ROCKEFELLER UNIVERSITY
    Inventors: Olga YURIEVA, John KURIYAN, Michael E. O'DONNELL, David JERUZALMI
  • Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof
    Patent number: 7556958
    Abstract: A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus, and corresponds to Polymerase III in E. coli. The genes and the polypeptides corresponding to T.th. ?, ?, ?, ? and ? subunits that they encode are disclosed, as are probes, vectors, methods of preparation and the methods of use. The enzymes of the present invention and their components are particularly well suited for use in procedures for the preparation of DNA, such as PCR, because of the speed and accuracy that they are able to achieve.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: July 7, 2009
    Assignee: The Rockefeller University
    Inventors: Olga Yurieva, John Kuriyan, Michael E. O'Donnell, David Jeruzalmi
  • Nucleic acid encoding Bacillus stearothermophilus delta prime polymerase subunit
    Publication number: 20050153299
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: July 14, 2005
    Inventors: Michael O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Bacillus stearothermophilus tau, delta, and delta prime polymerase subunits and use thereof
    Publication number: 20050112580
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: May 26, 2005
    Inventors: Michael O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Nucleic acid encoding Bacillus stearothermophilus polc polymerase subunit
    Publication number: 20050100920
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: May 12, 2005
    Inventors: Michael O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Aquifex aeolicus delta prime polymerase subunit and use thereof
    Publication number: 20050048510
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: March 3, 2005
    Inventors: Michael O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Nucleic acid encoding bacillus stearothermophilus beta polymerase subunit
    Publication number: 20040197796
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: October 7, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Bacillus stearothermophilus SSB protein and use thereof
    Publication number: 20040110210
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: June 10, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Nucleic acid encoding bacillus stearothermophilus SSB protein
    Publication number: 20040106137
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polyrnerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: June 3, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Bacillus stearothermophilus beta polymerase subunit and use thereof
    Publication number: 20040081995
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 29, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Bacillus stearothermophilus polc polymerase subunit and use thereof
    Publication number: 20040077012
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: April 22, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Thermotoga maritima delta prime polymerase subunit and use thereof
    Publication number: 20040048309
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 26, 2003
    Publication date: March 11, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Nucleic acid encoding bacillus stearothermophilus tau polymerase subunit
    Publication number: 20040043414
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: March 4, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Nucleic acid encoding aquifex aeolicus delta prime polymerase subunit
    Publication number: 20040043415
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: March 4, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Nucleic acid encoding thermotoga maritima delta prime polymerase subunit
    Publication number: 20040038290
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: February 26, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan
  • Nucleic acid encoding bacillus stearothermophilus delta polymerase subunit
    Publication number: 20040038289
    Abstract: The present invention relates to an isolated DNA molecule from a thermophilic bacterium which encodes a DNA polymerase III-type enzyme subunit. Also encompassed by the present invention are host cells and expression system including the heterologous DNA molecule of the present invention, as well as isolated replication enzyme subunits encoded by such DNA molecules. Also disclosed is a method of producing a recombinant thermostable DNA polymerase III-type enzyme, or subunit thereof, from a thermophilic bacterium, which is carried out by transforming a host cell with at least one heterologous DNA molecule of the present invention under conditions suitable for expression of the DNA polymerase III-type enzyme, or subunit thereof, and then isolating the DNA polymerase III-type enzyme, or subunit thereof.
    Type: Application
    Filed: September 25, 2003
    Publication date: February 26, 2004
    Inventors: Michael E. O'Donnell, Alexander Yuzhakov, Olga Yurieva, David Jeruzalmi, Irina Bruck, John Kuriyan