Patents by Inventor John Kuriyan

John Kuriyan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Dimerization interface of signal transducer and activator of transcription (STAT) proteins
    Publication number: 20040009571
    Abstract: The invention identifies an interface domain for interaction between two or more dimers of Signal Transducer and Activator of Transcription (STAT) proteins formed between amino acid residues Gln8 (Q8), Ile12 (I12), and Leu15 (L15) of &agr; helices 1 and 2, Met28 (M28) and Glu29 (E29) of &agr; helix 3 of a first STAT protein partner of the dimer, and Leu77 (L77) and Leu78 (L78) in &agr; helix 7 of a second STAT protein partner of the dimer. The interface domain is useful for designing and identifying compounds capable of enhancing or inhibiting binding between STAT protein dimers and/or DNA binding sites, and thus useful for identifying compounds able to modulate STAT protein dimer-dimer induction of gene expression.
    Type: Application
    Filed: June 25, 2002
    Publication date: January 15, 2004
    Inventors: John Kuriyan, James E. Darnell, Xiaomin Chen, Focco Van den Akker
  • Method of using a crystal of the N-terminal domain of a signal transducer and activator of transcription
    Publication number: 20030003563
    Abstract: The present invention provides a crystal containing the N-terminal domain of a STAT protein that is of sufficient quality to perform X-ray crystallographic studies. Methods of preparing the crystals are include in the invention. The present invention further discloses the three-dimensional structure of the crystal. The present invention also provides methods of using the structural information in drug discovery and drug development.
    Type: Application
    Filed: October 19, 2001
    Publication date: January 2, 2003
    Inventors: Uwe Vinkemeier, Ismail Moarefi, James E. Darnell, John Kuriyan
  • Method of using a crystal of the N-terminal domain of a signal transducer and activator of transcription
    Patent number: 6312887
    Abstract: The present invention provides a crystal containing the N-terminal domain of a STAT protein that is of sufficient quality to perform X-ray crystallographic studies. Methods of preparing the crystals are include in the invention. The present invention further discloses the three-dimensional structure of the crystal. The present invention also provides methods of using the structural information in drug discovery and drug development.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: November 6, 2001
    Assignee: The Rockefeller University
    Inventors: Uwe Vinkemeier, Ismail Moarefi, James E. Darnell, Jr., John Kuriyan
  • Crystal of the core portion of a signal transducer and activator of transcription (STAT)
    Patent number: 6160092
    Abstract: The present invention provides a crystal of the core portion of the STAT protein in dimeric form with an 18-mer duplex DNA that contains a binding site for the STAT-dimer. The crystal is of sufficient quality to perform X-ray crystallographic studies. Methods of preparing the crystals are include in the invention. The present invention further discloses the three-dimensional structure of the crystal. The present invention also provides methods of using the structural information in drug discovery and drug development.
    Type: Grant
    Filed: May 29, 1998
    Date of Patent: December 12, 2000
    Assignee: The Rockefeller University
    Inventors: Xiaomin Chen, Uwe Vinkemeier, Yanxiang Zhao, David Jeruzalmi, James E. Darnell, Jr., John Kuriyan
  • Crystal of a Ras-Sos complex and methods of use thereof
    Patent number: 6156526
    Abstract: A detailed three-dimensional structure for the complex formed between Ras and the Son of sevenless (Sos) protein is provided. Crystals of this complex are also included in the invention. The present invention farther provides procedures for identifying agents that can inhibit tumor proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
    Type: Grant
    Filed: July 21, 1998
    Date of Patent: December 5, 2000
    Assignees: The Rockerfeller University, The Research Foundation of State University of New York
    Inventors: Ann Boriack-Sjodin, S. Mariana Margarit, Dafna Bar-Sagi, Philip Cole, John Kuriyan
  • Crystal of a Ras-Sos complex
    Patent number: 6117663
    Abstract: A detailed three-dimensional structure for the complex formed between Ras and the Son of sevenless (Sos) protein is provided. Crystals of this complex are also included in the invention. The present invention further provides procedures for identifying agents that can inhibit tumor proliferation through the use of rational drug design predicated on the crystals and crystallographic data disclosed.
    Type: Grant
    Filed: July 19, 1999
    Date of Patent: September 12, 2000
    Assignees: The Rockefeller University, The Research Foundation of State University of New York
    Inventors: Ann Boriack-Sjodin, S. Mariana Margarit, Dafna Bar-Sagi, Philip Cole, John Kuriyan
  • Crystal of the N-terminal domain of a STAT protein and methods of use thereof
    Patent number: 6087478
    Abstract: The present invention provides a crystal containing the N-terminal domain of a STAT protein that is of sufficient quality to perform X-ray crystallographic studies. Methods of preparing the crystals are include in the invention. The present invention further discloses the three-dimensional structure of the crystal. The present invention also provides methods of using the structural information in drug discovery and drug development.
    Type: Grant
    Filed: January 23, 1998
    Date of Patent: July 11, 2000
    Assignee: The Rockefeller University
    Inventors: Uwe Vinkemeier, Ismail Moarefi, James E. Darnell, Jr., John Kuriyan
  • Peptides specific for the first Crk-SH3 domain
    Patent number: 5888763
    Abstract: The present invention relates to regulation and control of cellular processes by SH3-domain binding proteins and peptides. In particular, the invention provides a consensus sequence of a peptide that shows high specificity and affinity for the first SH3 domain of cellular Crk. In specific examples, a number of peptides that contain the consensus are shown to bind c-Crk specifically. The molecular basis for this specificity is examined by crystallography.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: March 30, 1999
    Assignee: The Rockefeller University
    Inventors: Hidesaburo Hanafusa, Beatrice S. Knudsen, Stephan M. Feller, John Kuriyan, Xiaodong Wu, Jie Zheng, David Cowburn