Abstract: A hydroentangled patterned apertured web comprises a plurality of land areas in the patterned apertured web, and a plurality of apertures defined in the patterned apertured web. At least some land areas of the plurality of land areas surround at least some apertures of the plurality of apertures. The plurality of apertures comprises a first set of apertures defining a heart shape and a second set of apertures defining a diamond shape. The heart shape is positioned within the diamond shape. The diamond shape encloses the heart shape. At least one land area of the plurality of land areas separates the heart shape from the diamond shape. The patterned apertured web comprises spunbond fibers.

Abstract: This document relates to methods and materials for treating a mammal having an autoimmune disease. For example, materials and methods for producing a T cell comprising a FOXP3 polypeptide and one or more transcription factors are provided herein. Methods and materials for treating a mammal having an autoimmune disease comprising administering to a mammal having an autoimmune disease an effective amount of a T cell are also provided herein.

Abstract: A disposable diaper product useful for collecting a urine sample from an infant is disclosed. In one example the product may have a liquid control structure overlying a liquid impermeable backsheet, with a plan surface area defining a volume coextensive therewith, wherein a portion of the volume defined by at least 50 percent of the plan surface area contains no more than 50 percent by weight absorbent material. In another example the product may have a liquid control structure overlying a liquid impermeable backsheet, and have an average Liquid Release Ratio of at least 3 percent. A method for collecting a urine sample from an infant is also disclosed, in which a diaper is used for collection.

Abstract: An appliance having a cabinet, a door connected to the cabinet and movable in an opening direction from a closed position to an open position, and a handle connected to the door. The handle has a first side facing against the opening direction and forming a grasping surface, a second side facing along the opening direction, and an interface region having one or more input interfaces on the second side of the handle. The appliance has one or more shutoff sensors configured to disable at least one of the one or more input interfaces on the interface region when an object is detected adjacent the grasping surface.

Abstract: A process management tool for managing transport of a material between a first location and a second location is disclosed. The process management tool includes a communication device configured to receive data messages, a display device, an input device configured to receive user inputs, and a processor in communication with the communication device, the display device, and the input device. The processor is configured to generate a graphical user interface on the display device. The graphical user interface includes a map indicative of a position of each of one or more transport vehicles with respect to the first location and the second location. The graphical user interface further includes a first graphical object indicative of a spacing between a first transport vehicle and a second transport vehicle of the one or more transport vehicles and a second graphical object indicative of a process parameter associated with the material.

Abstract: The present application discloses heteroaromatic and heterobicyclic aromatic derivative compounds and compositions, and methods for treating ferroptosis-related disorders and diseases inpatients using the compounds and compositions as disclosed herein.

Abstract: This document relates to methods and materials for treating a mammal having an autoimmune disease. For example, materials and methods for producing a T cell comprising a FOXP3 polypeptide and one or more transcription factors are provided herein. Methods and materials for treating a mammal having an autoimmune disease comprising administering to a mammal having an autoimmune disease an effective amount of a T cell are also provided herein.

Abstract: An absorbent article including a liquid permeable topsheet on a wearer-facing side of the absorbent article and a garment-facing laminate on a garment-facing side of the absorbent article is disclosed. The garment-facing laminate includes a backsheet film and a nonwoven layer joined to the backsheet film. The nonwoven layer defines a plurality of apertures. At least 3 of the plurality of apertures in a repeat unit have a different Effective Aperture Area, according to the Aperture Test herein, a different shape, and a different Absolute Feret Angle, according to the Aperture Test herein. The absorbent article includes an absorbent core disposed at least partially intermediate the liquid permeable topsheet and the garment-facing laminate.

Abstract: Methods and pharmaceutical combinations for preventing, reducing the occurrence of, and/or treating an infection in a subject are provided herein. The method includes administering to the subject a therapeutically effective amount of an IL-15 agonist after or concomitantly with administration of a therapeutically effective amount of an antibiotic to the subject. The pharmaceutical combination includes an IL-15 agonist and an antibiotic.

Abstract: Fibronectin type III (FN3) domain antibodies, polynucleotides capable of encoding the FN3 domain antibodies or antigen-binding fragments, cells expressing FN3 domain antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled FN3 domain antibodies or antigen-binding fragments may be used to engineer FN3 domain-targeting chimeric antigen receptors (CARs). Methods of making the FN3 domain antibodies, CARs, and engineered immune cells, and methods of using the engineered immune cells are applicable to treat diseases including cancer.

Abstract: The present invention relates to compounds having activity at the human glucose-dependent insulinotropic polypeptide (GIP) receptor. The present invention also relates to compounds having an extended duration of action at the GIP receptor. Such compounds may be useful in the treatment of diabetes, including type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: A composition comprising branched fructan molecules derived from a fructan extract of perennial high sugar grass (HSG) selected from the group consisting of AberMagic cultivar, AberDart cultivar, and S48 (Lolium spp), and obtained by enzymic endo-hydrolase hydrolysis, wherein said branched fructan molecules have a molecular weight of between 0.3 to 3 kDa, and wherein at least 50% of the branched fructan molecules present in the composition have a molecular weight of between 0.48 and 1.9 kDa is provided. Also provided are feed or food supplement comprising such a composition, a method of producing a composition comprising branched fructan molecules, and a method of making a feed or foodstuff.

Abstract: Example techniques herein filter and classify security-relevant events from monitored computing devices. A control unit can receive event records of various types, each event record associated with a monitored device. The control unit can provide, for each event record matching a corresponding pattern of a pattern set associated with the respective event type, a respective match record. Each match record can include an identifier of the corresponding pattern and data of the respective event record. The control unit can provide, for each match record satisfying a corresponding condition of a condition set, a respective candidate record including a tag associated with the corresponding condition. The control unit can provide, for each candidate record satisfying a tag criterion, a result record. Some examples can receive a modification record and use it to provide an updated condition set used for determining candidate records.

Abstract: This document relates to methods and materials for treating a mammal having an autoimmune disease. For example, materials and methods for producing a T cell comprising a FOXP3 polypeptide and a microRNA are provided herein. Also provided are methods of treating an autoimmune disease that include administering these T cells.

Abstract: A stackable sawblade containment assembly comprises a plurality of annular covers and an outer lip. The plurality of annular covers is defined by an outer perimeter, wherein each of the annular cover comprises a containment face and a base face, wherein at least one protrusion and at least one depression are coupled to the annular cover. The outer lip is disposed to extend along the outer perimeter and extending from the containment face. The at least one protrusion is disposed in general alignment with the at least one depression, whereby the at least one protrusion is configured to form a snap-fit relationship with the at least one depression. The containment face from one of the plurality of annular covers, and the base face from another one of the plurality of annular covers are detachably connected, forming an inner cavity and a stacked arrangement of annular covers.

Abstract: Provided herein are antibodies that selectively bind to EpCAM and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Abstract: An absorbent article comprising a topsheet, a backsheet, and an absorbent core disposed between the topsheet and the backsheet. The absorbent article comprises a first fluid handling zone having a first Transverse Fluid Travel Distance and a second fluid handling zone having a second Transverse Fluid Travel Distance. The first Transverse Fluid Travel Distance is at least about 50% greater than said second Transverse Fluid Travel Distance, which results in an absorbent article that is better able to handle bodily fluids and reduce the risk of accidental leakage of bodily fluids onto a consumer's undergarments.

Abstract: A modular robot is provided. The modular robot includes a sweeper module having a container for collecting debris from a surface of a location. The sweeper module is coupled to one or more brushes for contacting the surface and moving said debris into said container. Included is a robot module having wheels and configured to couple to the sweeper module. The robot module is enabled for autonomous movement and corresponding movement of the sweeper module over the surface. A controller is integrated with the robot module and interfacing with the sweeper module. The controller is configured to execute instructions for assigning of at least two zones at the location and assigning a work function to be performed using the sweeper module at each of the at least two zones. The controller is further configured for programming the robot module to activate the sweeper module in each of the two zones. The assigned work function is set for performance at each of the at least two zones.

Abstract: Methods and software for setting parameters for operating a modular robot are disclosed. One method includes receiving, by a server, communications data from a controller of the modular robot. The modular robot has storage for storing program instructions for executing autonomous movement at a location. The method includes sending, by the server, calibrated mapping data for the location. The calibrated mapping data identifies an outline at the location. The method includes sending, by the server, identification of at least two zones at the location, where the at least two zones define different areas at the location. The method includes sending, by the server, a work function to be performed by the modular robot for each of the at least two zones. The work function in each of the at least two zones set to be different at said server.

Abstract: An article includes a chassis having a topsheet, backsheet and an absorbent core disposed between the topsheet and backsheet; and an ear joined to the chassis. The ear includes a ring-rolled laminate having a first nonwoven web and an elastomeric film; wherein the first nonwoven web has a crimped spunbond fiber nonwoven web.