Abstract: An absorbent article comprising a topsheet, a backsheet, and an absorbent core structure is disclosed, wherein the absorbent structure includes a wearer facing core layer including either a heterogeneous mass layer or a fibrous structure comprising a fibrous network, wherein a portion of the topsheet and wearer facing core layer are integrated such that they at least partially reside in the same X-Y plane.

Abstract: A process management tool for managing transport of a material between a first location and a second location is disclosed. The process management tool includes a communication device configured to receive data messages, a display device, an input device configured to receive user inputs, and a processor in communication with the communication device, the display device, and the input device. The processor is configured to generate a graphical user interface on the display device. The graphical user interface includes a map indicative of a position of each of one or more transport vehicles with respect to the first location and the second location. The graphical user interface further includes a first graphical object indicative of a spacing between a first transport vehicle and a second transport vehicle of the one or more transport vehicles and a second graphical object indicative of a process parameter associated with the material.

Abstract: An absorbent has longitudinal and lateral centerlines, first, second, and target regions, the target region being disposed between the first second regions. Each of the first, second target regions extend laterally across the disposable absorbent article. The disposable absorbent article also has a topsheet; a backsheet; an absorbent core disposed between the topsheet and backsheet; a fluid management layer disposed between the topsheet and absorbent core; and a target zone disposed in the target region. The target zone has a first plurality of conforming features in at least the absorbent core or a combination of the absorbent core and at least one of the topsheet or fluid management layer. The absorbent article also has a long fiber network.

Abstract: The invention provides compositions and methods containing alpha-helical polypeptides as permeation enhancers for effectuating the passage of therapeutic agents into the inner ear by passage through the round window membrane. Examples of permeation-enhancing peptides useful in conjunction with the compositions and methods described herein are facially amphipathic, positively charged peptides. The permeation-enhancing peptides of the disclosure may be used to effectuate the entry of a variety of therapeutic agents into the inner ear, such as proteins, antibodies, nucleic acids, viral vectors, and nanoparticles, among others. Upon accessing the inner ear, the therapeutic agents may migrate to a particular site at which they may exert their biological effect.

Abstract: An event can be associated with a monitored computing device and a command-line record. An event vector can be determined for each of a plurality of events based at least in part on at least a portion of the respective command-line record and on a trained representation mapping. A respective reduced event vector can be determined having fewer elements. The reduced event vectors can be clustered to determine cluster identifiers. A first event can be determined to be associated with a security violation based on a corresponding cluster identifier matching a cluster identifier of a second event that is associated with a security violation. In some examples, a cluster can include a relatively larger first group of events and a relatively smaller second group of events. That cluster can be determined to satisfy a criterion based on the numbers of events in at least one of the groups.

Abstract: The present invention relates to compounds having activity at the human glucose-dependent insulinotropic polypeptide (GIP) receptor. The present invention also relates to compounds having an extended duration of action at the GIP receptor. Such compounds may be useful in the treatment of diabetes, including type 2 diabetes mellitus (“T2DM”). Also, the compounds may be useful in the treatment of obesity.

Abstract: A shutoff valve device for permitting and preventing fluid flow in a production string. In one embodiments, the shutoff valve device comprising: a body comprising a borehole, wherein the body is a top sub coupled to a bottom sub via a threaded fastener; a flow tube disposed within the body's borehole and capable of axial movement within the body's borehole, comprising a flow tube borehole; a bi-directional actuator attached to a bottom opening of the flow tube, comprising flexible flaps; and a flapper valve disposed within the body's borehole, wherein the flapper valve is hingedly coupled to a top surface of the bottom sub and capable of moving between a fully opened and fully closed position.

Abstract: This document relates to methods and materials for treating a mammal having an autoimmune disease. For example, materials and methods for producing a T cell comprising a FOXP3 polypeptide. Methods and materials for treating a mammal having an autoimmune disease comprising administering to a mammal having an autoimmune disease an effective amount of a T cell are also provided herein.

Abstract: BCMA-specific fibronectin type III (FN3) domains, BCMA-targeting chimeric antigen receptors (CARs) comprising the FN3 domains, and engineered BCMA-targeting immune cells expressing the CARs are described. Also described are nucleic acids and expression vectors encoding the FN3 domains and the CARs, recombinant cells containing the vectors, and compositions comprising the engineered immune cells. Methods of making the FN3 domains, CARs, and engineered immune cells, and methods of using the engineered immune cells to treat diseases including cancer are also described.

Abstract: A compactor vibration system, apparatus, and method that selectively provide access to vibration control settings. The control can include receiving a setting for a first set of selectable amplitudes of vibration force at which to operate a vibratory system for a first predetermined amount of time, operating the vibratory system during the first predetermined amount of time by inducing the vibration force at amplitudes by the vibratory system, wherein the amplitudes of the vibration force are selected from among the first set of selectable amplitudes, and after the first predetermined amount of time, changing the setting to a second set of selectable amplitudes of the vibration force that is different from the first set of selectable amplitudes.

Abstract: A system provides content describing an object, for example, a physical object or a customizable service. The system presents an interactive user interface displaying a customized version of a physical object. The interactive user interface allows the user to further customize the physical object. The user interface displays a plurality of options for customizing various components of the physical object. The system customizes the physical object presented via the interactive user interface based on the user profile and user interactions of the user with other users via an online system. The system allows the user to further customize the physical object via the interactive user interface. The interactive user interface presents various options for customization of the physical object based on predicted user preferences.

Abstract: A construction vehicle includes a frame, at least one drum, and a vibratory system. The vibratory system includes a first eccentric weight, a second eccentric weight, and a shift assembly adapted to vary an amplitude of the vibratory system. The shift assembly includes a shaft member adapted to move along a first axis for changing a position of the first eccentric weight relative to the second eccentric weight. The shift assembly also includes an actuator and a fork assembly adapted to move the shaft member along the first axis. The fork assembly includes a fork fixedly coupled to the actuator. The fork assembly also includes a housing member concentrically disposed around the shaft member, wherein the fork is pivotally coupled to the housing member at a pair of pivot points defined proximate to the second end of the fork. The fork assembly further includes a bearing member.

Abstract: A method for operating an electronic device, comprising a plurality of displays, which includes a first body unit, a second body unit, a first display which is disposed on the other side of the first body unit and faces a first direction, a second display which is disposed on the other side of the second body unit and faces a second direction, and a processor configured to display on the first display a screen of a first application and, when the angle between the first body unit and the second body unit is smaller than a predetermined angle, display on the second display at least one of an image related to the first application, an image related to first content being executed by means of the first application and an image related to information obtained by means of the electronic device.

Abstract: A comminution system for heterogeneous materials includes pumps, a source of liquid in fluid communication with the pumps, a source of heterogeneous material, a mixer to combine the heterogeneous material and the liquid, and nozzles in fluid communication with the pumps, respectively. The pumps are in straight-line alignment with the nozzles. The nozzles receiving the heterogeneous material combined with the liquid direct the combined slurry to an impact zone where the fractions of the heterogeneous material are disassociated.

Abstract: Provided herein are antibodies that selectively bind to Tim-3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Abstract: A method may include receiving an indication that an electronic alert is to be transmitted to a user; obtaining contextual information associated with the user; determining a first time for presenting the electronic alert to the user based in part on the contextual information; transmitting the electronic alert to a computing device associated with the user at the first time; storing the electronic alert in a message feed data structure; receiving a request to view the electronic alert at a second time, the second time occurring after the first time; in response to the request, retrieving the electronic alert from the message feed data structure; and transmitting the electronic alert at the second time.

Abstract: Nonwoven webs/nonwoven laminates for use in absorbent articles are disclosed. The nonwoven webs/nonwoven laminates are useful in leg cuffs of absorbent articles.

Abstract: An automated annotation system to automatically designate annotations to records within a report, which may perform operations that include: designating an annotation to a location, the annotation comprising a text string; identifying a record of the location within a report; selecting the annotation based on the record of the location within the report; and applying the text string of the annotation to the record within the report, according to certain example embodiments.