Abstract: This disclosure relates to, inter alia, cells expressing both a chimeric antigen receptor (CAR) and membrane bound IL-12 and the use of these cells to target and treat cancers (e.g., solid tumors and cancers expressing CD19, CD22, BCMA, PSCA, HER2, TAG-72, and PSCA). The disclosure also relates to cells expressing a membrane bound IL-12.

Abstract: The present disclosure provides novel synthetic intermediates useful in the synthesis of MK2 kinase inhibitors.

Abstract: This application relates to a client-server architecture that enables progress tracking related to assignments generated by an instructor. A hand-out can include attachments that specify placeholders for hand-ins and/or activities to be performed by the student as part of the assignment. Some activities can be performed using third-party applications that implement at least a portion of a software framework that causes the applications to generate progress tracking information provided to a daemon executing in the background of a client device. The daemon and/or a client application interface with one or more network services to enable an instructor to utilize the progress tracking information. The network services can include a hand-out service utilized to generate hand-outs assigned to a group of students. The network services can also include a progress pipeline including a number of services configured to process progress tracking information received from a plurality of client devices.

Abstract: Embodiments are directed to a series of novel small molecule activators of NRF2 dependent gene expression that are evaluated in an effort to develop therapeutic methods against diseases with deregulated KEAP1-NRF2 signaling.

Abstract: A refrigeration system including a storage chamber configured to store a product at a predetermined temperature. The storage chamber is defined by an inner wall. The inner wall at least partially defines an air plenum. The inner wall includes an opening wall surface, a floor surface, a rear wall surface and a ceiling wall surface. The system also includes a refrigerant circuit including a compressor, a condenser, a condenser fan, an evaporator and an evaporator fan arranged and disposed in an operable configuration to provide refrigeration to the storage chamber. The air plenum includes a conduit arranged and disposed to convey air from an air inlet across the evaporator and into a discharge chamber and out an air outlet. The air outlet is configured to discharge cooled air in a direction toward the opening wall surface.

Abstract: A method for updates in a storage system is provided. The method includes writing identifiers, associated with data to be stored, to storage units of the storage system and writing trim records indicative of identifiers that are allowed to not exist in the storage system to the storage units. The method includes determining whether stored data corresponding to records of identifiers is valid based on the records of the identifiers and the trim records.

Abstract: An article of footwear with an upper having a knitted component in an instep region extending between lateral and medial sides. Outer lace apertures and inner lace apertures are disposed along the instep area on the lateral and medial sides, where inner lace apertures are located more inward towards a middle of the upper than outer lace apertures. A lace extends through an inner lace aperture from an exterior surface on the medial side of the upper, along an interior surface of the upper, and then exits the upper through an outer lace aperture on the medial side. After exiting the outer lace aperture on the medial side, the lace extends across the instep area along the exterior surface of the upper and extends through an inner lace aperture on the lateral side.

Abstract: A central database system provides predictive web navigation using machine learning and clustering to guide a user to a web page. After tracking a number of web pages viewed by various users on one or more web domains and the orders in which these web pages are viewed, the central database system can train a model to predict which web page a user is likely to view next. If the user is lost while navigating, the central database system may guide the user to the predicted web page. In one example of guidance, the central database system presents a web element with a hyperlink to the predicted web page. For example, the central database system can modify a web page that the lost user is presently viewing to include an iframe with a recommendation to travel to a different web page.

Abstract: Provided is a torch including a body having a first portion and a second portion angled relative to the first portion, a control knob at a top of the second portion for adjusting a flow of fuel through the torch, a trigger at a top of the first portion that is movable from an off position to an on position to at actuate an igniter, and a burn tube extending from an end of the second portion away from the first and second portions.

Abstract: Systems and methods for informed mobility platform for a customer service supervisor within a distribution facility are disclosed. One embodiment may be a supervisor mobile terminal including a transceiver circuit, a user interface and a controller. The transceiver circuit may wirelessly communicate with a server computer a plurality of sets of data relating to the customer service activities. The user interface may display at least one set of the plurality of sets of data and receive an instruction to modify the at least one set of data the plurality of sets of data. The controller may control the user interface to modify the at least one set of data based on the instruction and control the transceiver circuit to wirelessly communicate the modified data with the server computer such that the at least one set of data stored in the server computer is updated with the modified data.

Abstract: The present disclosure generally relates to methods for sending event notifications. In some examples, a controller periodically sends messages concerning a status of an event corresponding to the controller. In some examples, at a first time while periodically sending the messages and in accordance with a determination that the status of the event has changed, the controller sends a message concerning data other than the status of the event. In some examples, at the first time while periodically sending the messages and in accordance with a determination that the status of the event has not changed, the controller continues to periodically send the messages without sending the message concerning data other than the status of the event.

Abstract: The present disclosure relates generally to the field of medical devices. In particular, the present disclosure relates to a tissue traction device, e.g., for endoscopic tissue dissection. For example, a tissue traction device may include a first clip comprising opposable jaws. The device may include a traction band having a first end, a second end, a length therebetween and extending along a longitudinal axis. The band may have a first aperture at the first end. A second aperture may be at the second end of the band. A first jaw of the opposable jaws of the first clip may be disposed through the first aperture.

Abstract: Concepts presented herein relate to an interface module that can be electrically coupled to an electrical stimulation generator, a radio frequency generator and an instrument. A selection module is coupled to the interface module and operates in a first mode to deliver electrical stimulation signals from the electrical stimulation generator to the instrument and in a second mode to deliver radio frequency signals from the radio frequency generator to the instrument.

Abstract: A simulated process is initiated. The simulated process includes generating, by an emulator, a control signal based on external inputs. The simulated process further includes processing, by a simulator, the control signal to generate simulated response data. The simulated process further includes generating, by a deep learning processor, expected behavioral pattern data based on the simulated response data. An actual process is initiated by initializing setpoints for a process station in a manufacturing system. The actual process includes generating, by the deep learning processor, actual behavioral pattern data based on actual process data from the at least one process station. The deep learning processor compares the expected behavioral pattern to the actual behavioral pattern. Based on the comparing, the deep learning processor determines that anomalous activity is present in the manufacturing system. Based on the anomalous activity being present, the deep learning processor initiates an alert protocol.

Abstract: A surgical tunneling tool and a method of using the surgical tunneling tool are disclosed. In one embodiment, the surgical tunneling tool includes a flexible shaft including a lumen through which an anesthetic may be delivered subcutaneously. In another embodiment, the surgical tunneling tool includes a sheath disposed on a flexible shaft, the sheath including at least one channel through which an anesthetic may be delivered subcutaneously. The subcutaneous distribution of anesthetic may involve stepwise insertion of the surgical tunneling tool. The surgical tunneling tool may be used for insertion of a medical device into a patient after use of the surgical tunneling tool to anesthetize a subcutaneous pathway for the medical device.

Abstract: Described are metering dispensers having a body configured to hold a flowable composition in a chamber, a drive screw coupled to the body, and a plunger threadingly coupled to the drive screw. The plunger includes at least two annular lips that form a fluid seal with the chamber as the plunger travels along the drive screw through the chamber. A base is rotationally coupled to the body with a cam that contacts at least one tab extending externally from the body so that the tab enters at least one low point on the cam by traveling over a trailing edge of the low point, and the trailing edge then prevents the tab from exiting the low point in the direction of the trailing edge.

Abstract: A system includes a controlled acoustic source. The system also includes distributed acoustic sensors along a conduit. The distributed acoustic sensors obtain acoustic signal measurements as a function of position along the conduit in response to at least one acoustic signal provided by the controlled acoustic source. The system also includes a processing unit that generates an acoustic activity plot or report based on the acoustic signal measurements. The acoustic activity plot or report is used to identify at least one acoustic impedance boundary anomaly as a function of position along the conduit.

Abstract: Classifying wafers using Collaborative Learning. An initial wafer classification is determined by a rule-based model. A predicted wafer classification is determined by a machine learning model. Multiple users can manually review the classifications to confirm or modify, or to add user classifications. All of the classifications are input to the machine learning model to continuously update its scheme for detection and classification.

Abstract: Various examples are directed to systems and methods for detecting potentially fraudulent voice calls to a financial services institution. A computing system may receive an indication of a voice call placed by a voice caller to an operator. The computing system may generate a network address indicator describing a network location. The network address indicator may be provided to the voice caller. The computing system may receive an indication of a financial services account indicated by the voice caller. The computing system may also receive an indication of an access to the network location by a remote device. The computing system may determine, using the indication of the access to the network location, a first location associated with the remote device and determine that the first location does not match a second location associated with the financial services account. The computing system may generate an alert indicating that the voice call is potentially fraudulent.

Abstract: A system (1) for electrically stimulating a nerve (3), the system comprising: a first stimulator (5) and a second stimulator (7) for electrically stimulating the nerve, the first stimulator and the second stimulator spaced apart from one another by a first distance; and a controller (9) arranged to: a) set a time interval as a function of the first distance and the speed of propagation of an action potential in the nerve; b) activate the first stimulator for a first stimulation period, thus inducing electrical activity in the nerve; and c) activate the second stimulator for a second stimulation period after the time interval has elapsed after the end of the first time period. Preferably, the time interval is a sum of the first time period and a buffer time period for allowing the nerve to recover from stimulation.