Abstract: A recommendation service access a data matrix listing of products associated with product profiles, the data matrix having product entries that store sparse historical electronic activity. For a target product it is determined which other products should be used to boost the historical electronic activity of the target product based on a first subset of product profiles that share product characteristics with the target product. Similarity scores are computed between the product profile of the target product and the first subset of product profiles to identify a second subset of one or more products having a similarity score above a scoring threshold. The historical electronic activity of the target product is boosted using the historical electronic activity of the other products in the second subset. Association values are calculated between the target product and the other products in the second subset by based on the boosted activity.

Abstract: An anomaly detection system is disclosed capable of reporting anomalous processes or hosts in a computer network using machine learning models trained using unsupervised training techniques. In embodiments, the system assigns observed processes to a set of process categories based on the file system path of the program executed by the process. The system extracts a feature vector for each process or host from the observation records and applies the machine learning models to the feature vectors to determine an outlier metric each process or host. The processes or hosts with the highest outlier metrics are reported as detected anomalies to be further examined by security analysts. In embodiments, the machine learnings models may be periodically retrained based on new observation records using unsupervised machine learning techniques. Accordingly, the system allows the models to learn from newly observed data without requiring the new data to be manually labeled by humans.

Abstract: Provided herein are methods and systems for use with peristaltic pumps. More particularly, provided herein are peristaltic pump systems that include a dampener for reducing the pulsations of the flowrate from the peristaltic pump system to produce, mix, transfer and/or manufacture pharmaceutical compositions and formulations, including pharmaceutical compositions and formulations comprising lipids and RNA.

Abstract: A lyophilization method for lyophilizing products inside one or more vials within a lyophilization chamber is disclosed which includes humidifying a charge gas to a predetermined relative humidity, cooling shelves in the lyophilization chamber to a predetermined temperature, pressurizing the chamber with the humidified charge gas to a pressurization threshold to thereby achieving a target relative humidity level within the lyophilization chamber, and suddenly releasing pressure within the lyophilization chamber until a depressurization threshold is reached in a short time interval up to about 4 seconds, during the depressurization, product inside one or more vials nucleate.

Abstract: An anomaly detection system is disclosed capable of reporting anomalous processes or hosts in a computer network using machine learning models trained using unsupervised training techniques. In embodiments, the system assigns observed processes to a set of process categories based on the file system path of the program executed by the process. The system extracts a feature vector for each process or host from the observation records and applies the machine learning models to the feature vectors to determine an outlier metric each process or host. The processes or hosts with the highest outlier metrics are reported as detected anomalies to be further examined by security analysts. In embodiments, the machine learnings models may be periodically retrained based on new observation records using unsupervised machine learning techniques. Accordingly, the system allows the models to learn from newly observed data without requiring the new data to be manually labeled by humans.

Abstract: The present invention relates to methods and formulations useful for reducing the reconstitution time of lyophilized polypeptides.

Abstract: The present invention relates to methods and formulations useful for reducing the reconstitution time of lyophilized polypeptides.

Abstract: The present invention relates to methods and formulations useful for reducing the reconstitution time of lyophilized polypeptides.

Abstract: The present invention provides a system and method for sending a cellular text message to a system server through a data network, including an identification of a requested database record and a forward address. The system server then performs a database lookup or related search and sends an enhanced message or a file to the forward address, which could be a cellular phone, e-mail address, server, computer, mobile device, or any hardware or device associated with the intended recipient that is communicatively coupled to the system server.

Abstract: An optical sensor, optical system, and proximity sensor are disclosed. An illustrative proximity sensor is disclosed to include a light source, a photodetector including a photo-sensitive area that receives incident light and converts the received incident light into an electrical signal, and a plurality of polarization layers stacked on the photodetector that limit light from becoming received incident light for the photo-sensitive area to light traveling toward the photodetector along a predetermined path.

Abstract: An optical sensor, optical system, and proximity sensor are disclosed. An illustrative proximity sensor is disclosed to include a light source, a photodetector including a photo-sensitive area that receives incident light and converts the received incident light into an electrical signal, and a plurality of polarization layers stacked on the photodetector that limit light from becoming received incident light for the photo-sensitive area to light traveling toward the photodetector along a predetermined path.

Abstract: This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Abstract: The present invention provides a system and method for sending a cellular text message to a system server through a data network, including an identification of a requested database record and a forward address. The system server then performs a database lookup or related search and sends an enhanced message or a file to the forward address, which could be a cellular phone, e-mail address, server, computer, mobile device, or any hardware or device associated with the intended recipient that is communicatively coupled to the system server.

Abstract: The present invention provides a system and method for sending a cellular text message to a system server through a data network, including an identification of a requested database record and a forward address. The system server then performs a database lookup or related search and sends an enhanced message or a file to the forward address, which could be a cellular phone, e-mail address, server, computer, mobile device, or any hardware or device associated with the intended recipient that is communicatively coupled to the system server.

Abstract: A proximity sensor device, which may detect the presence of external objects at close proximity is disclosed. The proximity sensor device may comprise an emitter, a detector, a separation wall and an internal channeling section. In one embodiment, the internal channeling section may be configured to direct light from the emitter to the detector when the external object is present at close proximity. In other embodiments, a proximity sensor assembly, an optical structure and an electronic device having similar internal channeling section are disclosed.

Abstract: A proximity sensor device, which may detect the presence of external objects at close proximity is disclosed. The proximity sensor device may comprise an emitter, a detector, a separation wall and an internal channeling section. In one embodiment, the internal channeling section may be configured to direct light from the emitter to the detector when the external object is present at close proximity. In other embodiments, a proximity sensor assembly, an optical structure and an electronic device having similar internal channeling section are disclosed.

Abstract: The present invention relates to a method for use in injection molding with the capability to have precise and adjustable control of the molten plastic flow when molding at least two (2) non-identical (i.e. with more than 50% difference in weight or form) or identical complex-shaped and intricate plastic parts at the same time, utilising a mold with at least two (2) parting layers via a standard conventional injection machine. This invention incorporates the principle of having two (2) valve pins in which their movements are back-to-back and can be independently opened and closed as controlled by stepper, servo or linear motors linked to a separate independent tool controller. The two (2) valve pins are positioned at the floating half of the mold for sequential, stack or multi-layer mold with multiple cavities.

Abstract: The present disclosure provides methods of synthesizing alkylating agents and methods of use.

Abstract: Methods of alkylating target compounds are disclosed. The alkylating agent can be radiolabeled. In some instances, the alkylating agent is synthesized and then reacted with a target compound without an intervening purification step. The method comprises synthesizing an alkylating agent having the formula: X—(CR1R2)aCR3R4-LG wherein, a is 0, 1, 2 or 3, R1, R2, R3 and R4 are independently H, X or alkyl, X is a halogen or a label, with the proviso that at least one X is a halogen, LG is a leaving group; and directly reacting said alkylating agent with a target compound comprising an alkylation reactive group under conditions suitable for the alkylation of said target compound.

Abstract: Compounds of Formula I are inhibitors of HIV integrase and inhibitors of HIV replication: the asterisk * in Q denotes the point of attachment to the rest of the compound; and n, L1, L2, X1, X2, ?3, Y, Z, R1, R2 and R3 are defined herein. The N compounds are useful for the prophylaxis or treatment of infection by HIV and the prophylaxis, treatment, or delay in the onset or progression of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se (or as hydrates or solvates thereof) or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.